DermIDS: Dermatology imaging data structure for scalable and interoperable AI systems.
Cho C, McNeil AJ, Jiang B, Saunders AM, Rudravaram G, Liu Y, Moyer D, Dawant BM, Landman BA, Tkaczyk ER.
Proc SPIE Int Soc Opt Eng. 2026 Feb;13930:139300V. doi: 10.1117/12.3085989. Epub 2026 Apr 2.
PMID: 42038928 Free PMC article.
Abstract: Dermatologic imaging has been rapidly expanding, with over 70% of related PubMed articles published since 2016 and over a million images across international research challenges and large-scale datasets with skin images. To improve data quality and usability, standardizing dermatologic imaging data for non-protected health information (non-PHI) research systems is essential. While the International Skin Imaging Collaboration (ISIC) has advanced standards in skin imaging, the field lacks a generalizable infrastructure to organize and describe imaging data for non-PHI research systems. This results in inconsistently labeled, heterogeneous datasets that hinder data integration, scalability, and interoperability. To address this gap, we propose the Dermatology Imaging Data Structure (DermIDS), inspired by the Brain Imaging Data Structure (BIDS) for neuroimaging. This structured framework aims to improve usability across datasets, reveal metadata gaps, and enable scalable artificial intelligence (AI)/machine learning (ML)-ready workflows. To illustrate this system, we curated and processed 1,000,692 images with DermIDS. We demonstrate that DermIDS (1) supports multimodal photographic data acquired from clinical photography, general photography, dermoscopy, reflectance confocal microscopy, and surface 3D imaging; (2) facilitates image-specific technical and clinical metadata organization; and (3) streamlines quality control and harmonization. Across all images, 1,256 unique metadata features were identified. However, 70% of clinical metadata features and 98% of technical metadata features were present in less than 100k images, highlighting key gaps and demonstrating the utility of DermIDS in revealing inconsistencies and opportunities for standardization. Our work supports large-scale analysis and harmonization, laying the foundation for AI/ML-ready workflows to advance dermatologic imaging research.
Keywords: AI/ML-ready; data management; dermatologic imaging; harmonization; interoperability; metadata; multimodal data; scalable.
The anatomy and molecular inventory of Staphylococcus aureus abscesses.
Enriquez KT, Skaar EP.
Trends Microbiol. 2026 Mar 24:S0966-842X(26)00031-4. doi: 10.1016/j.tim.2026.02.005. Online ahead of print.
PMID: 41881696 Review.
Abstract: Staphylococcus aureus is an opportunistic pathogen that infects practically every body site despite differences in nutritional environment, immune milieu, and mode of inoculation. S. aureus abscesses are pathophysiological structures wherein host-derived extracellular matrix and immune cells form layers surrounding a S. aureus colony. Staphylococcal abscess communities seed staphylococcal abscesses, which are associated with worse S. aureus infection outcomes. Abscesses are also an example of the host-S. aureus interface, wherein host and pathogen adaptations define the spatial and temporal features of pathogenesis as well as the outcomes of infection. This review discusses recent discoveries in abscess formation made across organ systems and highlights findings involving host and pathogen determinants of abscess formation that improve our understanding of S. aureus pathogenesis.
Keywords: Staphylococcus aureus; abscess; bacterial pathogenesis; host–microbe interface; staphylococcal abscess community.
Unmasking pathogen traits for chronic colonization in neurogenic bladder.
Reasoner SA, Frainey BT, Hale OF, Borden A, Graham MK, Turner E, Brenes LR, Soderstrom CBW, Green H, Schmitz JE, Laub MT, Kelly MS, Clayton DB, Hadjifrangiskou M.
Cell Rep. 2026 Apr 22;45(5):117302. doi: 10.1016/j.celrep.2026.117302. Online ahead of print.
PMID: 42024499 Free article.
Abstract: Individuals with neurogenic bladder are susceptible to chronic bacterial colonization and urinary tract infections. Neurogenic bladder arises from conditions including spinal cord injuries and spina bifida. We established a longitudinal cohort of 77 children and young adults with spina bifida. Using enhanced urine culture, 16S rRNA sequencing, and whole-genome sequencing of bacterial isolates, we characterized the urine microbiota. We also retrieved prior bacterial isolates from Vanderbilt’s MicroVU biobank, enabling 5-year evolutionary comparisons within subjects. Urine samples showed high abundance of pathogens, including E. coli and Klebsiella. Across time points, subjects exhibited either rapid cycling of strains, often after antibiotics, or persistence of a single strain. Neither pattern consistently correlated with increased antibiotic resistance. Instead, mutations in cell envelope genes mediated immune evasion and altered phage susceptibility, highlighting fitness trade-offs induced by niche adaptation to the bladder. This cohort enables the identification of bacterial adaptation mechanisms.
Keywords: CP: microbiology; bacterial evolution; spina bifida; urinary microbiome; urinary tract infection; urobiome.
A molecularly defined polymeric platform for environmentally responsive activation of STING to enhance cancer immunotherapy.
Schulman JA, Arora K, Kwiatkowski AJ, Chada NC, Steele JA, Pagendarm HM, Woodworth ME, Sheehy TL, Gibson-Corley K, Balko JM, Wilson JT.
Biomaterials. 2026 Apr 30;334:124238. doi: 10.1016/j.biomaterials.2026.124238. Online ahead of print.
PMID: 42097025 Free article.
Integrating 2D Dermatological Photography with 3D Anatomical Surfaces.
Jiang B, Liu Y, McNeil AJ, Cho C, Saknite I, Pavletic SZ, Cowen EW, Weiss R, Landman BA, Dawant BM, Tkaczyk ER.
Proc SPIE Int Soc Opt Eng. 2026 Feb;13926:1392621. doi: 10.1117/12.3085708. Epub 2026 Apr 2.
PMID: 42039876 Free PMC article.
GEN-KnowRD: Reframing AI for Rare Disease Recognition.
Yan C, Su WC, Xin Y, Grabowska ME, Kerchberger VE, Borza VA, Wang J, Wang L, Li R, Lynn J, Dickson AL, Shyr C, Feng Q, Stein CM, Wang K, Embi PJ, Malin BA, Liu H, Wei WQ.
medRxiv [Preprint]. 2026 Mar 3:2026.03.02.26347469. doi: 10.64898/2026.03.02.26347469.
PMID: 41867212 Free PMC article. Preprint.
Quantitative Spatial Profiling of Antibody Delivery and Target Engagement Using Optically Labeled Antibodies.
Tanaka H, Vasiukov G, Grisham CJ, Kazi M, Gowrishankar S, Rosenthal EL.
J Nucl Med. 2026 Apr 22:jnumed.125.271992. doi: 10.2967/jnumed.125.271992. Online ahead of print.
PMID: 42020148
Relating latent factors of reasoning, affect, and cognition to the delusional experience.
Halverson A, Kittleson AR, Liu J, So SH, Sheffield JM.
Schizophrenia (Heidelb). 2026 Apr 24. doi: 10.1038/s41537-026-00750-1. Online ahead of print.
PMID: 42031844 Free article.
Longitudinal relationships among dissociation, paranoia, and anxiety in a clinical sample of individuals with schizophrenia-spectrum conditions.
Lebovitz JG, Kittleson AR, Sloan AF, Torregrossa LJ, Park S, Sheffield JM.
Psychiatry Res. 2026 Apr 15;362:117174. doi: 10.1016/j.psychres.2026.117174. Online ahead of print.
PMID: 42054844 Free article.
PRECISE: A prognostic thyrocyte-derived gene signature for papillary thyroid carcinoma.
Li S, Wu CC, Marczyk VR, Loberg MA, Thennavan A, Tarabichi M, Xu L, Henderson YC, Martin ME, Tran TM, Duose DY, Sanchez-Espitia A, Luthra R, Sheng Q, Xu GJ, Huang EC, Hofmann MC, Zhao X, Lai SY, Hosseini SM, Williams MD, Wang W, Hamidi S, Zafereo ME, Cabanillas ME, Navin NE, Weiss VL, Wang JR.
Clin Cancer Res. 2026 Apr 20. doi: 10.1158/1078-0432.CCR-25-4488. Online ahead of print.
PMID: 42008746
Antiseizure Networks.
Schaper FLWVJ, Giampiccolo D, Makhoul GS, Devergnas AD, Englot DJ, Forcelli PA.
Epilepsy Curr. 2026 Apr 15:15357597261436900. doi: 10.1177/15357597261436900. Online ahead of print.
PMID: 42007174 Free PMC article.
Expanded Biological Characterization of Autograft-Derived Contributions to Spinal Fusion: Graft-Derived Progenitors Contribute via Endochondral Bone Formation.
Kawabata A, Okonkwo DD, Oyaizu T, Stephens BF, Louer CR, Moore-Lotridge SN, Mckee RM, Reese JC, Egawa S, Yoshii T, Schoenecker JG.
Spine J. 2026 May 6:S1529-9430(26)00133-6. doi: 10.1016/j.spinee.2026.04.028. Online ahead of print.
PMID: 42102905
Pre-illness Clonal Hematopoiesis of Indeterminate Potential is an Independent Predictor of Morbidity and Mortality in Sepsis.
Berg NK, Kerchberger VE, Pershad Y, Corty RW, Bick AG, Ware LB.
medRxiv [Preprint]. 2026 Apr 15:2026.04.14.26350864. doi: 10.64898/2026.04.14.26350864.
PMID: 42064936 Free PMC article. Preprint.
Mosaic Loss of Y chromosome associates with lung function, emphysema and epigenetic aging.
Saw WY, Kim K, Huang Y, Yun JH, Ma X, Bacon J, Pershad Y, Levy D, O’Connor GT, Boerwinkle E, Barr RG, Rich SS, Rotter JI, Carson AP, Raffield LM, Gharib SA, Bartz TM, Psaty BM, Sofer T, North KE, Kaplan R, Oelsner EC, Manichaikul A, Bick AG, Scheet P, Reiner AP; NHLBI Trans-Omics for Precision Medicine Consortium; Jakubek YA, Auer PL, Cho MH, DeMeo DL.
Am J Respir Crit Care Med. 2026 Mar 19:aamag120. doi: 10.1093/ajrccm/aamag120. Online ahead of print.
PMID: 42085243
Reply.
Zhao K, Pershad Y, Bick AG, Corty RW.
Arthritis Rheumatol. 2026 May 4. doi: 10.1002/art.70204. Online ahead of print.
PMID: 42077050 No abstract available.
From Constraint to Opportunity: 10°C Static Cold Storage Allows Prolonged Ischemic Time and Attenuates Severe Primary Graft Dysfunction Risk in Adult Heart Transplantation.
Ahmad A, Trahanas JM, Wang CC, Bommareddi S, Lima B, Absi T, Quintana E, Petrovic M, McGann K, Devries S, Lowman J, Siddiqi H, Menachem JN, Rali AS, Scholl SR, Schwartz CA, Keck C, Bacchetta M, Schlendorf K, Shah AS, Williams AM.
J Thorac Cardiovasc Surg. 2026 Apr 28:S0022-5223(26)00905-0. doi: 10.1016/j.jtcvs.2026.04.016. Online ahead of print.
PMID: 42061605
Low Intraoperative Oxygen Extraction During Heart Transplant Reduces Primary Graft Dysfunction Risk in Allografts with Prolonged Ischemic Time.
Ahmad A, Wang CC, Bommareddi S, Trahanas JM, McGann KC, Absi T, Quintana E, Petrovic M, Devries S, Lowman J, Lepore AJ, Siddiqi H, Brinkley M, Menachem JN, Pedrotty D, Tsai S, Rali AS, Sacks S, Zalawadiya S, Bacchetta M, Schlendorf K, Shah AS, Lima B, Williams AM.
J Thorac Cardiovasc Surg. 2026 May 3:S0022-5223(26)00852-4. doi: 10.1016/j.jtcvs.2026.03.611. Online ahead of print.
PMID: 42086166
Genetic Risk, Healthy Lifestyle, and Risk Stratification for Diverticulitis.
Ueland TE, Shelley JP, Mosley JD, Robinson JR, Gamazon ER, Maguire LL, Peek R, Sharp K, Hawkins AT.
J Am Coll Surg. 2026 Apr 1;242(4):899-907. doi: 10.1097/XCS.0000000000001778. Epub 2026 Jan 22.
PMID: 41568825 Free PMC article.