Congratulations to the lab for being awarded our first NIH grant!
The NIH-MIRA R35 (RFA-GM-16-003) grant is entitled: Deciphering post-transcriptional gene regulatory networks in cellular stress and innate immunity.
The grant will allow us to pursue the following major biological questions:
1)How do RNA-binding proteins regulate gene expression of their targets during an innate immune response?
2)What is the nature and impact of RNA methylation on mRNAs upon interferon/cGAMP stimulation? And how do such changes affect RBP assembly and function?
3) How are the genomes of RNA viruses deployed during the early stages of infection, and what host- or viral-encoded RNA-binding proteins facilitate this process?
4) What are the regulatory co-factors required for the activating or repressing cGAS-STING signaling? and can we identify small molecule compounds for the development of experimental probes and pre-therapeutic scaffolds?
Recent lectures presented by Manny
May 8-12, 2016: Keystone Conference Short Talk on Nucleic Acid Sensing Pathways: Innate Immunity, Immunobiology, and Therapeutics in Dresden, Germany.
Recent conferences attended by trainees
- Congratulations to Sarah Arcos for being selected as a trainee of the Chemical Biology of Infectious Disease (CBID) Training Program.
- Congratulations to Katherine Rothamel for passing her Biochemistry Ph.D. qualifying examination, and for being selected as a trainee of the Chemistry-Biology Interface Training Program.