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2021 NIH S10 Shared and High-End Instrumentation Grants

Vanderbilt University’s S10 Proposal Documents for Download (The following Word files will automatically download to your computer when clicked on):

Vanderbilt University SOP for NIH S10 Shared Instrumentation
S10 Combined Statement of Support
Dean Matching Letters Templates

Vanderbilt University:  Guidelines for NIH S10 Shared Instrumentation Grants

These guidelines pertain to all faculty Principal Investigators (PIs) who have Primary Appointments in one of the Vanderbilt University Schools or Colleges, including the Vanderbilt School of Medicine Basic Sciences (VBS) for proposal requesting instrumentation that will be housed and managed in a VU core.

The NIH has now posted information for the 2021 S10 Shared and High-end Instrumentation Grants programs. These programs and links to their program announcements are:

Shared Instrumentation Grant Program (SIG) – the SIG Program funds grant awards in the $50,000 to $600,000 range.

High-End Instrumentation Grant Program (HEI) – the HEI Program funds grant awards in the $600,000 to $2,000,000 range.

Both programs have an NIH submission deadline of June 1, 2021.

Submission of an S10 proposal to the NIH requires institutional pre-approval. For all VU faculty, including those in the Vanderbilt School of Medicine Basic Sciences (VBS), approval is obtained by submitting a pre-proposal to the Office of the Vice Provost for Research (OVPR) via the S10 VU REDCap survey. The deadline for submission of pre-proposals is April 1, 2021.  The pre-proposal process is fairly involved.  Please do not wait till the last minute to compile the needed information and documents. Note that a number of the materials required for the pre-proposal will be part of the full proposal and will therefore not need to be completed again.  Note also that the vast majority of fully completed pre-proposals are approved to move forward in the selection process and are ultimately submitted to the NIH as full proposals. There is a complete SOP which contains guidelines and requirements for submitting an S10 proposal which can be found in the VBS S10 SOP.  It is critical that you read this SOP carefully before attempting to complete the REDCap Survey.

S10 VU REDCap Survey link:

Pre-proposals much be submitted NO LATER than Thursday, April 1, 2021. This insures both adequate time for consideration by the Offices of the Dean and Vice Provost and for subsequent preparation of full proposals in time for the June 1st NIH submission deadline.

If you have any questions, investigators in Vanderbilt School of Medicine Basic Sciences (VBS) should contact Chuck Sanders at Investigators in other VU colleges/schools should contact Dr. Liane Moneta-Koehler at, or Susannah Imhoff at

*NOTE: VUMC PIs wishing to submit proposals DO NOT use the VU guidelines or the VU S10 REDCap survey. VUMC has a separate S10 process and set of guidelines which can be found on the VUMC S10 Internal Proposal Form. Please contact Amy Martinez in the VUMC Office of Research with any questions about the VUMC S10 program.