October 4, 2017

https://news.vanderbilt.edu/2017/09/28/cellular-calcium-handling-diabetes/

Tight regulation of calcium levels in the endoplasmic reticulum (ER) – a cellular organelle with multiple functions – contributes to insulin secretion by pancreatic beta cells. Although ER calcium handling is perturbed in diabetes, the molecular determinants of ER calcium balance are not clear. David Jacobson, Ph.D., and colleagues have now demonstrated that TALK-1 potassium channels located in the ER membrane facilitate calcium release from the ER in mouse and human beta cells.