November 17, 2017

Although dietary salt intake positively correlates with blood pressure, the mechanisms linking salt to hypertension are not well understood. In the Oct. 24 Cell Reports, Annet Kirabo, DVM, M.Sc., Ph.D., and colleagues identify a pathway by which excess sodium contributes to inflammation and hypertension. The researchers found that sodium enters immune system dendritic cells, ultimately resulting in the production of superoxide and the formation of immunogenic isolevuglandin-protein adducts. Salt-stimulated dendritic cells produce pro-inflammatory factors and activate T cells.