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Stephen W. Fesik, Ph.D.

Professor of Biochemistry & Pharmacology & Chemistry
Orrin H. Ingram II Chair in Cancer Research
Tadashi Inagami Chair in Biochemistry

Fragment and structure based drug discovery

Name: Fesik, Stephen W
Title: Professor of Biochemistry, Orrin H. Ingram II Chair in Cancer Research
Department: Biochemistry
Office Address: 634-A Robinson Research Building
Phone Number: 615-322-6303
Lab URL:

Research Keywords: Cancer drug discovery, fragment-based drug design, NMR, protein structure, RNAi

Research Description: The focus of our lab is on cancer drug discovery using fragment-based approaches and structure-based design. To accomplish this goal, we have assembled a multidisciplinary team that includes structural biologists, medicinal chemists, and cell biologists. Among them are five research professors and several research assistants, postdoctoral fellows, and graduate students. In our lab, we clone, express, and purify proteins, conduct fragment-based screens, determine the three-dimensional structures of protein/ligand complexes using NMR and/or X-ray crystallography, design and synthesize compounds, and test compounds in primary and secondary biological assays. The cancer drug targets that we are pursuing are highly validated but technically challenging such as K-Ras and c-Myc.

PubMed Listing of Dr. Fesik’s Publications