We focus on the following areas: 1) The cell biology of heart muscle cells (i.e., cardiomycoytes). 2) How both cardiomyocytes and cancer cells generate the forces driving their function. 3) Combining “omics” technologies with high resolution and high content microscopy.
Cellular contractile forces drive cell crawling, cell division and muscle contraction. Our work revolves around the molecular motor driving contraction in these three cellular contexts: myosin II. To study the mechanisms of how myosin II-based contractile systems assemble, we are combining high-resolution microscopy, high-content microscopy and genomic/proteomic approaches.
Keywords: cardiovascular , contraction , cell migration , cell division
Research Area: Imaging , Developmental Biology , Biophysics , Cardiovascular Biology , Cell Structure