Mariana Byndloss
Department of Pathology, Microbiology and Immunology (PMI)
Vanderbilt Institute for Infection, Immunology and Inflammation (VI4)
Vanderbilt-Ingram Cancer Center (VICC)
Vanderbilt Digestive Diseases Research Center (VDDRC)
Our group uses a multidisciplinary approach combining microbiology, molecular biology, cell biology, immunology and pathology to try to understand how inflammation-dependent changes in gut epithelial metabolism can result in gut dysbiosis and increased risk to non- communicable disease. Specifically, we used a variety of mouse models, including diet-induced-obesity, chemical-induced colitis, infectious gastroenteritis (Salmonella enterica serovar Typhiumurium), and germ-free animals with the goal to identify metabolic pathways in the gut bacteria and in the host response to microbiota-induced metabolites that will aid in prevention of human disease.
Our group uses a multidisciplinary approach combining microbiology, molecular biology, cell biology, immunology and pathology to try to understand how inflammation-dependent changes in gut epithelial metabolism can result in gut dysbiosis and increased risk to non- communicable disease. Specifically, we used a variety of mouse models, including diet-induced-obesity, chemical-induced colitis, infectious gastroenteritis (Salmonella enterica serovar Typhiumurium), and germ-free animals with the goal to identify metabolic pathways in the gut bacteria and in the host response to microbiota-induced metabolites that will aid in prevention of human disease.
Keywords: gut microbiota , inflammation , host-pathogen interactions , bacterial pathogenesis , metabolism , colonic epithelium
Research Area: Diabetes, Obesity, Metabolism , Host-Pathogen Interactions , Epithelial Biology , Molecular Pathology