Research Opportunities at Vanderbilt
Faculty List
First Name | Last Name | Room | Description | Key Word | Profile | Department | |
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Patrick AbbotI work on the evolution of species interactions in plants and insects, and the evolution and genomics of pregnancy in mammals. I integrate diverse approaches, from molecular biology to ecology. Keywords: evolution , genomics , pregnancy , social behavior , symbiosis , Computational and Systems Biology , Genomics , Evolution |
Patrick | Abbot |
I work on the evolution of species interactions in plants and insects, and the evolution and genomics of pregnancy in mammals. I integrate diverse approaches, from molecular biology to ecology. |
Keywords: evolution , genomics , pregnancy , social behavior , symbiosis Computational and Systems Biology , Genomics , Evolution | |||
Chris AikenMy laboratory aims to understand the molecular events controlling early events of HIV infection. We are interested in the functions of the viral capsid and its interactions with host factors, with an view toward developing novel antiviral therapies targeting it. Keywords: Virology , HIV , capsid , host restriction , virus maturation , antivirals , Drug Design , Host-Pathogen Interactions , Virology |
Chris | Aiken |
My laboratory aims to understand the molecular events controlling early events of HIV infection. We are interested in the functions of the viral capsid and its interactions with host factors, with an view toward developing novel antiviral therapies targeting it. |
Keywords: Virology , HIV , capsid , host restriction , virus maturation , antivirals Drug Design , Host-Pathogen Interactions , Virology | |||
Melinda AldrichKeywords: lung cancer , disparities , precision medicine , genetic epidemiology , biobanks , Computational and Systems Biology , Genomics , Cancer Biology , Molecular Pathology |
Melinda | Aldrich | Keywords: lung cancer , disparities , precision medicine , genetic epidemiology , biobanks Computational and Systems Biology , Genomics , Cancer Biology , Molecular Pathology | ||||
Matt AlexanderDr. Alexander’s laboratory is focused on the role of adaptive immunity in the pathogenesis of hypertension and associated cardiovascular disease. Current projects are focused on the role of counter-regulatory immune mechanisms in hypertension, including the role of novel regulatory T cell subsets in the pathogenesis of hypertension and microvascular dysfunction. We perform cutting edge basic and translational research integrating vascular biology and immunology using a variety of approaches including molecular biology, physiology, highly dimensional single cell analysis, and human genetics. Keywords: Hypertension , Immunology , Inflammation , Cardiovascular , Cardiology , Lymphocyte , Cardiovascular Biology , Immunology , Vascular Biology |
Matt | Alexander |
|
Dr. Alexander’s laboratory is focused on the role of adaptive immunity in the pathogenesis of hypertension and associated cardiovascular disease. Current projects are focused on the role of counter-regulatory immune mechanisms in hypertension, including the role of novel regulatory T cell subsets in the pathogenesis of hypertension and microvascular dysfunction. We perform cutting edge basic and translational research integrating vascular biology and immunology using a variety of approaches including molecular biology, physiology, highly dimensional single cell analysis, and human genetics. |
Keywords: Hypertension , Immunology , Inflammation , Cardiovascular , Cardiology , Lymphocyte Cardiovascular Biology , Immunology , Vascular Biology | ||
Holly AlgoodProjects in Dr. Algood’s lab focus on pathogen – host interactions in chronic infections and during chronic inflammation. Her projects investigate how T cell cytokines influence gastric epithelial cells responding to infection but also even more broadly how T cell cytokines activate other cells to protect the epithelial cells and the mucosal barrier they maintain. The main model system the laboratory uses to address these processes is H. pylori, but she is interested in many processes in mucosal immunology. Keywords: Host-pathogen interactions , Mucosal Immunology , T lymphocyte responses , inflammation , gastric cancer , Host-Pathogen Interactions , Epithelial Biology , Bacteriology , Immunology , Cancer Biology , Cancer Immunology |
Holly | Algood |
Projects in Dr. Algood’s lab focus on pathogen – host interactions in chronic infections and during chronic inflammation. Her projects investigate how T cell cytokines influence gastric epithelial cells responding to infection but also even more broadly how T cell cytokines activate other cells to protect the epithelial cells and the mucosal barrier they maintain. The main model system the laboratory uses to address these processes is H. pylori, but she is interested in many processes in mucosal immunology. |
Keywords: Host-pathogen interactions , Mucosal Immunology , T lymphocyte responses , inflammation , gastric cancer Host-Pathogen Interactions , Epithelial Biology , Bacteriology , Immunology , Cancer Biology , Cancer Immunology | |||
David AronoffOur lab studies reproductive immunology with a focus on bacterial infections that complicate pregnancy. We primarily examine host-microbe interactions in the pathogenesis of chorioamnionitis, a major cause of preterm birth and stillbirth. Group B Streptococcus is the primary pathogen our lab studies. Join us! Keywords: |
David | Aronoff |
Our lab studies reproductive immunology with a focus on bacterial infections that complicate pregnancy. We primarily examine host-microbe interactions in the pathogenesis of chorioamnionitis, a major cause of preterm birth and stillbirth. Group B Streptococcus is the primary pathogen our lab studies. Join us! |
Keywords: | |||
Manny AscanoWe study the post-transcriptional networks that govern gene expression during the innate immune activation of cells. We use and develop an inherently multidisciplinary set of tools to answer our questions including: biochemistry, chemical biology, transcriptomics, proteomics, and computational biology. Keywords: |
Manny | Ascano |
We study the post-transcriptional networks that govern gene expression during the innate immune activation of cells. We use and develop an inherently multidisciplinary set of tools to answer our questions including: biochemistry, chemical biology, transcriptomics, proteomics, and computational biology. |
Keywords: | |||
Thomas AuneOur research focuses on the use of functional genomic and epigenetic approaches to understand gene regulation. Our interests range from detailed mechanistic studies of the interferon-gamma gene, a key cytokine produced by cells of the innate and adaptive immune system, to the use of these approaches to gain new insights into human disease. In addition, we have begun to focus our attention on long noncoding RNAs (lncRNAs) and other species of RNAs that do not code for proteins. We have developed model organisms, computational and analytic pipelines to dissect enhancer function and functions of these newly identified RNA species in biologic systems. Keywords: genomics , enhancers , long non-coding RNA , epigenetics , RNA Biology , Gene Regulation , Immunology , Molecular Pathology |
Thomas | Aune |
Our research focuses on the use of functional genomic and epigenetic approaches to understand gene regulation. Our interests range from detailed mechanistic studies of the interferon-gamma gene, a key cytokine produced by cells of the innate and adaptive immune system, to the use of these approaches to gain new insights into human disease. In addition, we have begun to focus our attention on long noncoding RNAs (lncRNAs) and other species of RNAs that do not code for proteins. We have developed model organisms, computational and analytic pipelines to dissect enhancer function and functions of these newly identified RNA species in biologic systems. |
Keywords: genomics , enhancers , long non-coding RNA , epigenetics RNA Biology , Gene Regulation , Immunology , Molecular Pathology | |||
Julio AyalaMy lab is interested in gut-brain interactions that play a role in the maintenance of energy homeostasis. We focus on local effects of the gut hormone glucagon-like peptide-1 (Glp1) in the gut and both the peripheral and central nervous systems that regulate nutrient intake and energy expenditure. Our approaches include using transgenic mice, metabolic phenotyping, behavioral assays and opto/chemogenetics. Keywords: Glucagon-like peptide-1 , Brain , Food Intake , Energy Expenditure , Reward , Diabetes, Obesity, Metabolism , Synaptic Function and Neuroendocrinology |
Julio | Ayala |
My lab is interested in gut-brain interactions that play a role in the maintenance of energy homeostasis. We focus on local effects of the gut hormone glucagon-like peptide-1 (Glp1) in the gut and both the peripheral and central nervous systems that regulate nutrient intake and energy expenditure. Our approaches include using transgenic mice, metabolic phenotyping, behavioral assays and opto/chemogenetics. |
Keywords: Glucagon-like peptide-1 , Brain , Food Intake , Energy Expenditure , Reward Diabetes, Obesity, Metabolism , Synaptic Function and Neuroendocrinology | |||
Brian BachmannThe Vanderbilt Laboratory for Biosynthetic Studies (Bachmann, P.I.) studies and harnesses the biosynthetic capabilities of living systems in order to radically accelerate the discovery of new bioactive compounds and revolutionize how molecules are synthesized. By studying pathways and enzymes involved in secondary metabolism, we create new biochemical knowledge, and apply it toward the generation of new bioactive molecules. Our precision-medicine drug discovery subgroup uses a single cell chemical biology paradigm on patient-derived cells to drive the discovery of secondary metabolites as cures for cancer. Keywords: Drug Discovery , Synthetic Biology , Enzymology , Natural Products , Cancer , Precision Medicine , Drug Design , Cancer Biology , Chemical Biology , Cell Signaling , Evolution |
Brian | Bachmann |
The Vanderbilt Laboratory for Biosynthetic Studies (Bachmann, P.I.) studies and harnesses the biosynthetic capabilities of living systems in order to radically accelerate the discovery of new bioactive compounds and revolutionize how molecules are synthesized. By studying pathways and enzymes involved in secondary metabolism, we create new biochemical knowledge, and apply it toward the generation of new bioactive molecules. Our precision-medicine drug discovery subgroup uses a single cell chemical biology paradigm on patient-derived cells to drive the discovery of secondary metabolites as cures for cancer. |
Keywords: Drug Discovery , Synthetic Biology , Enzymology , Natural Products , Cancer , Precision Medicine Drug Design , Cancer Biology , Chemical Biology , Cell Signaling , Evolution | |||
Justin BalkoOur laboratory is focused on improving treatment oucomes in breast cancer (particularly triple-negative breast cancer) as well as in other solid tumors. To accomplish this, we integrate data from genomic and molecular profiling studies with molecular biology and signal transduction methodologies to translationally identify altered pathways in cancer, the functional consequences of these alterations, and ways to directly target them in patients to improve clinical outcomes and survival. Keywords: immunotherapy , breast cancer , melanoma , translational , computational biology , Computational and Systems Biology , Genomics , Cancer Biology , Cell Signaling , Cancer Immunology |
Justin | Balko |
Our laboratory is focused on improving treatment oucomes in breast cancer (particularly triple-negative breast cancer) as well as in other solid tumors. To accomplish this, we integrate data from genomic and molecular profiling studies with molecular biology and signal transduction methodologies to translationally identify altered pathways in cancer, the functional consequences of these alterations, and ways to directly target them in patients to improve clinical outcomes and survival. |
Keywords: immunotherapy , breast cancer , melanoma , translational , computational biology Computational and Systems Biology , Genomics , Cancer Biology , Cell Signaling , Cancer Immunology | |||
Julie BastaracheMy lab studies cellular and molecular mechanisms of lung alveolar capillary barrier function in sepsis and acute respiratory distress syndrome. We use state of the art cell and mouse models to define the key cellular processes that drive disruption of the alveolar capillary barrier. Mechanistic studies are complemented by translational studies in human models of lung injury. Keywords: |
Julie | Bastarache |
My lab studies cellular and molecular mechanisms of lung alveolar capillary barrier function in sepsis and acute respiratory distress syndrome. We use state of the art cell and mouse models to define the key cellular processes that drive disruption of the alveolar capillary barrier. Mechanistic studies are complemented by translational studies in human models of lung injury. |
Keywords: | |||
Robert BeauchampWe study colorectal carcinogenesis and metastasis biology. Our recent work has identified a previously unrecognized role of TGFbeta signaling in controlling epithelial inflammation, and links this role with tumor suppression. Our lab also seeks to identify novel therapeutic targets and molecular biomarkers. Keywords: Inflammation and cancer , Transforming growth factor beta , SMAD signaling , Molecular biomarkers , Mouse models of cancer , Colorectal cancer , Epithelial Biology , Cancer Biology , Cell Signaling |
Robert | Beauchamp |
We study colorectal carcinogenesis and metastasis biology. Our recent work has identified a previously unrecognized role of TGFbeta signaling in controlling epithelial inflammation, and links this role with tumor suppression. Our lab also seeks to identify novel therapeutic targets and molecular biomarkers. |
Keywords: Inflammation and cancer , Transforming growth factor beta , SMAD signaling , Molecular biomarkers , Mouse models of cancer , Colorectal cancer Epithelial Biology , Cancer Biology , Cell Signaling | |||
Megan BehringerExperimental Evolution and Population Genetics of Microbes. Our lab is interested in how genetic variation is introduced into a bacterial population and bacteria diversify as they colonize a novel environment. The phenotypes associated with this diversification often include biofilm formation, antimicrobial susceptibility, resource utilization, pH tolerance, changes in mutation rate, etc. We examine these questions on an individual (mutation accumulation), population (batch culture), and community (metagenomics) level. For more information see our lab’s website: http://www.behringerlab.wixsite.com/index Keywords: Evolution , Genomics , Microbiology , Population Genetics , Bacterial Genetics , Microbiome , Bacteriology , Cell Cycle, DNA Repair, and Chromosome Biology , Computational and Systems Biology , Gene Regulation , Genomics , Host-Pathogen Interactions |
Megan | Behringer |
Experimental Evolution and Population Genetics of Microbes. Our lab is interested in how genetic variation is introduced into a bacterial population and bacteria diversify as they colonize a novel environment. The phenotypes associated with this diversification often include biofilm formation, antimicrobial susceptibility, resource utilization, pH tolerance, changes in mutation rate, etc. We examine these questions on an individual (mutation accumulation), population (batch culture), and community (metagenomics) level. For more information see our lab’s website: http://www.behringerlab.wixsite.com/index |
Keywords: Evolution , Genomics , Microbiology , Population Genetics , Bacterial Genetics , Microbiome Bacteriology , Cell Cycle, DNA Repair, and Chromosome Biology , Computational and Systems Biology , Gene Regulation , Genomics , Host-Pathogen Interactions | |||
Jennifer (Piper) BelowGenerally, I am interested in developing and applying computational methodologies to further our understanding of the genetic basis of human disease. Specifically, I focus on development of novel strategies for identifying and confirming genetic risk factors to complex traits including blood lipid levels, diabetes, obesity, Alzheimer’s disease, cardiovascular disease, and metabolic traits via ascertainment of dense genetic (specifically, whole genome/exome sequenced and whole genome imputed datasets) and phenotypic data. Keywords: genomics , relatedness , disease gene mapping , transcriptomics , pheWAS , GWAS , Computational and Systems Biology , Diabetes, Obesity, Metabolism , Genomics , Cardiovascular Biology , Neurodegeneration and Neuroinflammation |
Jennifer (Piper) | Below |
Generally, I am interested in developing and applying computational methodologies to further our understanding of the genetic basis of human disease. Specifically, I focus on development of novel strategies for identifying and confirming genetic risk factors to complex traits including blood lipid levels, diabetes, obesity, Alzheimer’s disease, cardiovascular disease, and metabolic traits via ascertainment of dense genetic (specifically, whole genome/exome sequenced and whole genome imputed datasets) and phenotypic data. |
Keywords: genomics , relatedness , disease gene mapping , transcriptomics , pheWAS , GWAS Computational and Systems Biology , Diabetes, Obesity, Metabolism , Genomics , Cardiovascular Biology , Neurodegeneration and Neuroinflammation | |||
Jada Benn TorresJada Benn Torres, PhD, is a genetic anthropologist , Associate Professor, and Director of the Genetic Anthropology and Biocultural Studies Laboratory at Vanderbilt University in Nashville, Tennessee, USA. For the past 17 years, Dr. Benn Torres has researched the population genetics of Caribbean communities in order to examine their ancestry, colonial, and post-colonial experiences. Her second emerging research interest combines the tools and methods of genetic epidemiology with anthropology in order to holistically examine women’s health disparities across human populations. Keywords: genetic anthropology , ancestry , admixture , health disparities , women’s health |
Jada | Benn Torres |
Jada Benn Torres, PhD, is a genetic anthropologist , Associate Professor, and Director of the Genetic Anthropology and Biocultural Studies Laboratory at Vanderbilt University in Nashville, Tennessee, USA. For the past 17 years, Dr. Benn Torres has researched the population genetics of Caribbean communities in order to examine their ancestry, colonial, and post-colonial experiences. Her second emerging research interest combines the tools and methods of genetic epidemiology with anthropology in order to holistically examine women’s health disparities across human populations. |
Keywords: genetic anthropology , ancestry , admixture , health disparities , women’s health | |||
Ray BlindThe Blind Lab uses structural biology, molecular genomics and chemical biology to discover new ways nuclear lipid signaling controls gene expression. We apply these discoveries to the design and implementation of novel drug screens, developing therapeutics for diabetes, cancer and fatty liver. Keywords: Nuclear Lipid Signaling , Phospholipids , Structural Biology , Gene Expression , Genomics , Drug Design , Structural Biology , Diabetes, Obesity, Metabolism , Gene Regulation , Genomics , Chemical Biology |
Ray | Blind |
The Blind Lab uses structural biology, molecular genomics and chemical biology to discover new ways nuclear lipid signaling controls gene expression. We apply these discoveries to the design and implementation of novel drug screens, developing therapeutics for diabetes, cancer and fatty liver. |
Keywords: Nuclear Lipid Signaling , Phospholipids , Structural Biology , Gene Expression , Genomics , Drug Design Structural Biology , Diabetes, Obesity, Metabolism , Gene Regulation , Genomics , Chemical Biology | |||
Rachel BonamiOur overarching goal is to identify mechanisms by which autoantigen-specific B lymphocytes breach immune tolerance barriers to drive autoimmune disease. We apply cutting-edge hybridoma and single-cell RNAseq/CITEseq/BCRseq technology to study this process in type 1 diabetes, myositis, and immune checkpoint inhibitor-induced autoimmunity. Keywords: immunology , computational immunology , B cell , type 1 diabetes , autoimmune disease , , Cancer Immunology , Computational and Systems Biology , Diabetes, Obesity, Metabolism , Immunology |
Rachel | Bonami |
Our overarching goal is to identify mechanisms by which autoantigen-specific B lymphocytes breach immune tolerance barriers to drive autoimmune disease. We apply cutting-edge hybridoma and single-cell RNAseq/CITEseq/BCRseq technology to study this process in type 1 diabetes, myositis, and immune checkpoint inhibitor-induced autoimmunity. |
Keywords: immunology , computational immunology , B cell , type 1 diabetes , autoimmune disease , Cancer Immunology , Computational and Systems Biology , Diabetes, Obesity, Metabolism , Immunology | |||
Seth BordensteinWe endeavor to understand the principles that shape interactions between animals, microbes, and viruses and the basic and translational outcomes of these interactions. We employ hypothesis-driven approaches to study two forms of animal-microbe associations: intimate symbioses (between animals, obligate intracellular bacteria and bacteriophages) that impact animal reproduction and vector control, and facultative associations (between free-living organisms) that shape genome and microbiome evolution across the tree of life. Keywords: Microbiome , Virus , Symbiosis , Evolution , Genomics , Computational and Systems Biology , Host-Pathogen Interactions , Genomics , Virology , Bacteriology , Evolution |
Seth | Bordenstein |
We endeavor to understand the principles that shape interactions between animals, microbes, and viruses and the basic and translational outcomes of these interactions. We employ hypothesis-driven approaches to study two forms of animal-microbe associations: intimate symbioses (between animals, obligate intracellular bacteria and bacteriophages) that impact animal reproduction and vector control, and facultative associations (between free-living organisms) that shape genome and microbiome evolution across the tree of life. |
Keywords: Microbiome , Virus , Symbiosis , Evolution , Genomics Computational and Systems Biology , Host-Pathogen Interactions , Genomics , Virology , Bacteriology , Evolution | |||
Alan BrashPolyunsaturated fatty acids (PUFA) are easily oxidized, and enzymes (“oxygenases”) take advantage of this to form lipid signaling mediators such as the prostaglandins and leukotrienes. The focus of Alan Brash’s research is the mechanism of biosynthesis of these oxygenated lipids and their biological role. We employ a wide variety of analytical methods on tissues and cells and recombinant enzymes, with structural analysis of enzymic products by HPLC, UV-Visible spectroscopy, mass spectrometry, and NMR. Keywords: lipoxygenase , cyclooxygenase , cytochrome P450 , analytical chemistry , fatty acid biochemistry & chemistry , Structural Biology , Drug Design , Proteomics/Metabolomics |
Alan | Brash |
Polyunsaturated fatty acids (PUFA) are easily oxidized, and enzymes (“oxygenases”) take advantage of this to form lipid signaling mediators such as the prostaglandins and leukotrienes. The focus of Alan Brash’s research is the mechanism of biosynthesis of these oxygenated lipids and their biological role. We employ a wide variety of analytical methods on tissues and cells and recombinant enzymes, with structural analysis of enzymic products by HPLC, UV-Visible spectroscopy, mass spectrometry, and NMR. |
Keywords: lipoxygenase , cyclooxygenase , cytochrome P450 , analytical chemistry , fatty acid biochemistry & chemistry Structural Biology , Drug Design , Proteomics/Metabolomics | |||
Rich BreyerPharmacology and Physiology of Prostaglandin Receptors especially as it relates to blood pressure control, diabetes mellitus and Alzhheimer’s Disease. Keywords: Inflammation , GPCR , Pharmacology , Alzheimer's Disease , Hypertension , Diabetes , Diabetes, Obesity, Metabolism , Cardiovascular Biology , Cell Signaling , Neurodegeneration and Neuroinflamation |
Rich | Breyer |
Pharmacology and Physiology of Prostaglandin Receptors especially as it relates to blood pressure control, diabetes mellitus and Alzhheimer’s Disease. |
Keywords: Inflammation , GPCR , Pharmacology , Alzheimer's Disease , Hypertension , Diabetes Diabetes, Obesity, Metabolism , Cardiovascular Biology , Cell Signaling , Neurodegeneration and Neuroinflamation | |||
Kendal BroadieWe pursue the genetic dissection of nervous system development, function and adaptive plasticity, to understand the molecular mechanisms by which neural circuits mediate behavior. We generate genetic models of heritable neurological disorders, including autism spectrum disorders, intellectual disabilities and neurodegeneration states, in order to discover underlying causes and design cures. Our work spans from genes to behavior with molecular biology, biochemistry, light and electron microscopy, electrophysiology and behavioral output studies. Keywords: development , neuroscience , genetics , synapse , learning/memory , Drosophila , Neurodegeneration and Neuroinflamation , Synaptic Function and Neuroendocrinology , Developmental Biology |
Kendal | Broadie |
We pursue the genetic dissection of nervous system development, function and adaptive plasticity, to understand the molecular mechanisms by which neural circuits mediate behavior. We generate genetic models of heritable neurological disorders, including autism spectrum disorders, intellectual disabilities and neurodegeneration states, in order to discover underlying causes and design cures. Our work spans from genes to behavior with molecular biology, biochemistry, light and electron microscopy, electrophysiology and behavioral output studies. |
Keywords: development , neuroscience , genetics , synapse , learning/memory , Drosophila Neurodegeneration and Neuroinflamation , Synaptic Function and Neuroendocrinology , Developmental Biology | |||
Breann BrownMitochondrial protein-protein interactions and assembly are necessary for maintaining proper human health. Unfortunately, there are numerous painful, debilitating, and life-threatening diseases that occur due to genetic mutations that prevent proper protein assembly. Our approach is to use X-ray crystallography and other complementary biochemical techniques to understand how these various mutations lead to changes in protein structure and function, thus preventing proper macromolecular assembly. Keywords: x-ray crystallography , mitochondria , protein structure-function , heme , neurodegeneration , Structural Biology , Biophysics , Neurodegeneration and Neuroinflamation |
Breann | Brown |
Mitochondrial protein-protein interactions and assembly are necessary for maintaining proper human health. Unfortunately, there are numerous painful, debilitating, and life-threatening diseases that occur due to genetic mutations that prevent proper protein assembly. Our approach is to use X-ray crystallography and other complementary biochemical techniques to understand how these various mutations lead to changes in protein structure and function, thus preventing proper macromolecular assembly. |
Keywords: x-ray crystallography , mitochondria , protein structure-function , heme , neurodegeneration Structural Biology , Biophysics , Neurodegeneration and Neuroinflamation | |||
Kristopher BurkewitzThe Burkewitz lab is interested in combating age-onset diseases like neurodegeneration, cardiovascular disease, cancer and diabetes by understanding and targeting their common risk factor: the aging process itself. A combination of molecular genetic, biochemical and imaging approaches allows us to study interventions such as dietary restriction, which extends lifespan in a variety of animal models. In particular, we focus on understanding aging and longevity at the level of organelle function and cell architecture. Keywords: |
Kristopher | Burkewitz |
The Burkewitz lab is interested in combating age-onset diseases like neurodegeneration, cardiovascular disease, cancer and diabetes by understanding and targeting their common risk factor: the aging process itself. A combination of molecular genetic, biochemical and imaging approaches allows us to study interventions such as dietary restriction, which extends lifespan in a variety of animal models. In particular, we focus on understanding aging and longevity at the level of organelle function and cell architecture. |
Keywords: | |||
Dylan BurnetteWe focus on the following areas: 1) The cell biology of heart muscle cells (i.e., cardiomycoytes). 2) How both cardiomyocytes and cancer cells generate the forces driving their function. 3) Combining “omics” technologies with high resolution and high content microscopy. Keywords: cardiovascular , contraction , cell migration , cell division , Imaging , Developmental Biology , Biophysics , Cardiovascular Biology , Cell Structure |
Dylan | Burnette |
We focus on the following areas: 1) The cell biology of heart muscle cells (i.e., cardiomycoytes). 2) How both cardiomyocytes and cancer cells generate the forces driving their function. 3) Combining “omics” technologies with high resolution and high content microscopy. |
Keywords: cardiovascular , contraction , cell migration , cell division Imaging , Developmental Biology , Biophysics , Cardiovascular Biology , Cell Structure | |||
Mariana ByndlossOur group uses a multidisciplinary approach combining microbiology, molecular biology, cell biology, immunology and pathology to try to understand how inflammation-dependent changes in gut epithelial metabolism can result in gut dysbiosis and increased risk to non- communicable disease. Specifically, we used a variety of mouse models, including diet-induced-obesity, chemical-induced colitis, infectious gastroenteritis (Salmonella enterica serovar Typhiumurium), and germ-free animals with the goal to identify metabolic pathways in the gut bacteria and in the host response to microbiota-induced metabolites that will aid in prevention of human disease. Keywords: gut microbiota , inflammation , host-pathogen interactions , bacterial pathogenesis , metabolism , colonic epithelium , Diabetes, Obesity, Metabolism , Host-Pathogen Interactions , Epithelial Biology , Molecular Pathology |
Mariana | Byndloss |
Our group uses a multidisciplinary approach combining microbiology, molecular biology, cell biology, immunology and pathology to try to understand how inflammation-dependent changes in gut epithelial metabolism can result in gut dysbiosis and increased risk to non- communicable disease. Specifically, we used a variety of mouse models, including diet-induced-obesity, chemical-induced colitis, infectious gastroenteritis (Salmonella enterica serovar Typhiumurium), and germ-free animals with the goal to identify metabolic pathways in the gut bacteria and in the host response to microbiota-induced metabolites that will aid in prevention of human disease. |
Keywords: gut microbiota , inflammation , host-pathogen interactions , bacterial pathogenesis , metabolism , colonic epithelium Diabetes, Obesity, Metabolism , Host-Pathogen Interactions , Epithelial Biology , Molecular Pathology | |||
Erin CalipariThe interplay between rapid, temporally specific neuronal activation and longer-term changes in transcription is of critical importance in the expression of appropriate or, in the case of disease, inappropriate behaviors. Together, my research seeks to understand how information about stimuli is encoded in the brain. Developing new approaches to understand how activity-dependent changes are stored within particular cells and circuits at the level of the epigenome will allow us to understand adaptive and maladaptive processes in reward, motivation, and associative learning. Keywords: Circuits , Motivated Behaviors , Addiction , Dopamine , Reward , Learning , Gene Regulation , Neurodegeneration and Neuroinflamation , Developmental Neuroscience |
Erin | Calipari |
The interplay between rapid, temporally specific neuronal activation and longer-term changes in transcription is of critical importance in the expression of appropriate or, in the case of disease, inappropriate behaviors. Together, my research seeks to understand how information about stimuli is encoded in the brain. Developing new approaches to understand how activity-dependent changes are stored within particular cells and circuits at the level of the epigenome will allow us to understand adaptive and maladaptive processes in reward, motivation, and associative learning. |
Keywords: Circuits , Motivated Behaviors , Addiction , Dopamine , Reward , Learning Gene Regulation , Neurodegeneration and Neuroinflamation , Developmental Neuroscience | |||
Dave CalkinsOur group studies mechanisms of neurodegeneration in the visual system. Our objective is to probe the therapeutic potential of novel targets for intervention based on neuroprotection, repair, rehabilitation and regeneration. Keywords: visual system , neurodegenerative disorders , regenerative medicine , neuroprotection , neuronal-glial interactions , Stem Cell Biology & Regeneration , Visual Sciences , Neurodegeneration and Neuroinflamation |
Dave | Calkins |
Our group studies mechanisms of neurodegeneration in the visual system. Our objective is to probe the therapeutic potential of novel targets for intervention based on neuroprotection, repair, rehabilitation and regeneration. |
Keywords: visual system , neurodegenerative disorders , regenerative medicine , neuroprotection , neuronal-glial interactions Stem Cell Biology & Regeneration , Visual Sciences , Neurodegeneration and Neuroinflamation | |||
Bruce CarterWe study the molecular mechanisms regulating the development of the peripheral nervous system. Specifically, we focus on the regulation of neuronal apoptosis by the neurotrophins, the mechanisms by which the apoptotic neurons are cleared and the functional interplay between neurons and glia. Keywords: neuron , glia , Schwann , sensory , neurotrophin , apoptosis , Developmental Neuroscience , Developmental Biology , Neurodegeneration and Neuroinflamation |
Bruce | Carter |
We study the molecular mechanisms regulating the development of the peripheral nervous system. Specifically, we focus on the regulation of neuronal apoptosis by the neurotrophins, the mechanisms by which the apoptotic neurons are cleared and the functional interplay between neurons and glia. |
Keywords: neuron , glia , Schwann , sensory , neurotrophin , apoptosis Developmental Neuroscience , Developmental Biology , Neurodegeneration and Neuroinflamation | |||
Charles CaskeyMy lab explores the use of ultrasound for therapy and imaging. We have been developing magnetic resonance imaging-guided methods to use ultrasound for applications, such as neuromodulation, drug delivery, and immunomodulation. Keywords: ultrasound , medical imaging , imaging , MRI , therapy , neuromodulation , Drug Design , Imaging |
Charles | Caskey |
My lab explores the use of ultrasound for therapy and imaging. We have been developing magnetic resonance imaging-guided methods to use ultrasound for applications, such as neuromodulation, drug delivery, and immunomodulation. |
Keywords: ultrasound , medical imaging , imaging , MRI , therapy , neuromodulation Drug Design , Imaging | |||
Jim CassatOur lab studies host-pathogen interactions during invasive bacterial infections, with a specific focus on osteomyelitis. We are also interested in how inflammation and the microbiome impact skeletal cell biology. Finally, we study interconnections between the vertebrate immune and skeletal systems. Keywords: Staphylococcus aureus , Host-pathogen interactions , Microbiome , Bacterial Pathogenesis , Bone cell biology , Inflammatory bowel disease , Host-Pathogen Interactions , Immunology , Molecular Pathology , Bacteriology , Imaging |
Jim | Cassat |
Our lab studies host-pathogen interactions during invasive bacterial infections, with a specific focus on osteomyelitis. We are also interested in how inflammation and the microbiome impact skeletal cell biology. Finally, we study interconnections between the vertebrate immune and skeletal systems. |
Keywords: Staphylococcus aureus , Host-pathogen interactions , Microbiome , Bacterial Pathogenesis , Bone cell biology , Inflammatory bowel disease Host-Pathogen Interactions , Immunology , Molecular Pathology , Bacteriology , Imaging | |||
Walter ChazinWe have a broad range of interests, using the concepts and approaches of structural biochemistry to address key questions in medicine and biology. Three key factors govern our research: (1) a deep commitment to working with human proteins; (2) fascination with the mechanics of multi-protein machinery in genome maintenance and innate immunity; (3) firm belief in the power of collaboration and multi-disciplinary team science. Keywords: structural cell biology , genome maintenance , cancer , innate immunity , fragment-based molecular discovery , multi-protein complexes , biochemistry , Structural Biology , Drug Design , Cell Cycle, DNA Repair, and Chromosome Biology , Immunology , Cancer Biology |
Walter | Chazin |
We have a broad range of interests, using the concepts and approaches of structural biochemistry to address key questions in medicine and biology. Three key factors govern our research: (1) a deep commitment to working with human proteins; (2) fascination with the mechanics of multi-protein machinery in genome maintenance and innate immunity; (3) firm belief in the power of collaboration and multi-disciplinary team science. |
Keywords: structural cell biology , genome maintenance , cancer , innate immunity , fragment-based molecular discovery , multi-protein complexes , biochemistry Structural Biology , Drug Design , Cell Cycle, DNA Repair, and Chromosome Biology , Immunology , Cancer Biology | |||
Jin ChenCurrent focus of our lab is to investigate how receptor tyrosine kinase signaling in tumor cells affects glutamine metabolism and tumor immunity. We also study how tumor blood vessel normalization affect anti-tumor immune cells recruitment and activation. Keywords: tumor immunity , glutamine metabolism , tumor blood vessel normalization , EphA2 receptor tyrosine kinase , mTOR signaling , develop mTORC2-specific inhibitor , Drug Design , Cancer Biology , Cancer Immunology , Cell Signaling , Developmental Biology |
Jin | Chen |
Current focus of our lab is to investigate how receptor tyrosine kinase signaling in tumor cells affects glutamine metabolism and tumor immunity. We also study how tumor blood vessel normalization affect anti-tumor immune cells recruitment and activation. |
Keywords: tumor immunity , glutamine metabolism , tumor blood vessel normalization , EphA2 receptor tyrosine kinase , mTOR signaling , develop mTORC2-specific inhibitor Drug Design , Cancer Biology , Cancer Immunology , Cell Signaling , Developmental Biology | |||
Wenbiao ChenWe are interested in elucidating the molecular mechanisms underlying 1) pancreatic islet cell function and dysfunction, 2) communications between islet cells and other organs/tissues, and 3) tumorigenesis. We hope to use the new knowledge for treatment of diabetes and cancer. Keywords: diabetes , metabolism , insulin , glucagon , hyperplasia , tumorigenesis , Diabetes, Obesity, Metabolism , Cell Signaling , Developmental Biology |
Wenbiao | Chen |
We are interested in elucidating the molecular mechanisms underlying 1) pancreatic islet cell function and dysfunction, 2) communications between islet cells and other organs/tissues, and 3) tumorigenesis. We hope to use the new knowledge for treatment of diabetes and cancer. |
Keywords: diabetes , metabolism , insulin , glucagon , hyperplasia , tumorigenesis Diabetes, Obesity, Metabolism , Cell Signaling , Developmental Biology | |||
Chin ChiangThe Chiang lab is interested in how neurochemically distinct neurons are generated and how they contribute to associative motor learning, a process whereby the cerebellum learns an association between two sensory stimuli from the environment. Dysfunction in this process has been linked to neuropsychiatric disorders in humans such as autism. Another interest in the lab is to identify molecular and epigenetic mechanisms that contribute to medulloblastoma, the most common pediatric brain tumors in the cerebellum. Keywords: Brain , Neurogenesis , motor learning , Autism , tumor , Signaling , Cell Signaling , Developmental Neuroscience , Synaptic Function and Neuroendocrinology , Developmental Biology |
Chin | Chiang |
The Chiang lab is interested in how neurochemically distinct neurons are generated and how they contribute to associative motor learning, a process whereby the cerebellum learns an association between two sensory stimuli from the environment. Dysfunction in this process has been linked to neuropsychiatric disorders in humans such as autism. Another interest in the lab is to identify molecular and epigenetic mechanisms that contribute to medulloblastoma, the most common pediatric brain tumors in the cerebellum. |
Keywords: Brain , Neurogenesis , motor learning , Autism , tumor , Signaling Cell Signaling , Developmental Neuroscience , Synaptic Function and Neuroendocrinology , Developmental Biology | |||
Eunyoung Choi1. Defining the risk factors for gastric cancer development 2. Understanding progression and evolution of dysplastic stage to cancer as a key transition state in gastric carcinogenesis 3. Targeting the early stages of Ras-induced cancer Keywords: Carcinogenesis , Organoids , Mouse model , Cell heterogeneity , Cancer stem cells , Drug resistance , Cancer Biology , Developmental Biology , Stem Cell Biology & Regeneration |
Eunyoung | Choi |
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1. Defining the risk factors for gastric cancer development 2. Understanding progression and evolution of dysplastic stage to cancer as a key transition state in gastric carcinogenesis 3. Targeting the early stages of Ras-induced cancer |
Keywords: Carcinogenesis , Organoids , Mouse model , Cell heterogeneity , Cancer stem cells , Drug resistance Cancer Biology , Developmental Biology , Stem Cell Biology & Regeneration | ||
Roger ColbranThe Colbran Lab (https://lab.vanderbilt.edu/colbran-lab/) is focused on understanding the mechanisms controlling excitatory synaptic transmission and structure under physiological and pathophysiological conditions. We focus on calcium/calmodulin-dependent protein kinase II (CaMKII), an abundant postsynaptic signaling molecule with a unique auto-regulatory mechanism that mediates many downstream responses in neuronal dendrites. We are testing the over-arching hypothesis that direct interactions with diverse CaMKII-associated proteins modulate the activity, localization and/or substrate-specificity of CaMKII to confer specific downstream actions that have unique roles in modulating synaptic function and behavior. Keywords: Protein phosphorylation , Protein-protein interactions , Synaptic transmission , Dendritic spines , Autism , Transgenic mice , Cell Signaling , Synaptic Function and Neuroendocrinology |
Roger | Colbran |
The Colbran Lab (https://lab.vanderbilt.edu/colbran-lab/) is focused on understanding the mechanisms controlling excitatory synaptic transmission and structure under physiological and pathophysiological conditions. We focus on calcium/calmodulin-dependent protein kinase II (CaMKII), an abundant postsynaptic signaling molecule with a unique auto-regulatory mechanism that mediates many downstream responses in neuronal dendrites. We are testing the over-arching hypothesis that direct interactions with diverse CaMKII-associated proteins modulate the activity, localization and/or substrate-specificity of CaMKII to confer specific downstream actions that have unique roles in modulating synaptic function and behavior. |
Keywords: Protein phosphorylation , Protein-protein interactions , Synaptic transmission , Dendritic spines , Autism , Transgenic mice Cell Signaling , Synaptic Function and Neuroendocrinology | |||
Jeff ConnWe study the of specific neurotransmitter receptors in regulation of transmission and signaling in brain circuits involved in psychiatric and neurological disorders. From this, we endeavor to develop new treatment strategies for brain disorders and engage in full drug discovery efforts aimed at advancing new drug candidates into clinical development with industry partners. Keywords: |
Jeff | Conn |
We study the of specific neurotransmitter receptors in regulation of transmission and signaling in brain circuits involved in psychiatric and neurological disorders. From this, we endeavor to develop new treatment strategies for brain disorders and engage in full drug discovery efforts aimed at advancing new drug candidates into clinical development with industry partners. |
Keywords: | |||
David CortezOver six billion base pairs of DNA must be copied rapidly and accurately trillions of times in a human lifetime. My lab studies how this happens, the consequences of errors for human disease, and how we can intervene to improve health. We are particularly focused on how cells respond and repair DNA damage in the context of the cell division cycle. Keywords: DNA repair , cell cycle , DNA replication , cell signaling , cancer , genetic toxicology , Cell Cycle, DNA Repair, and Chromosome Biology , Cancer Biology , Cell Signaling , Proteomics/Metabolomics , Structural Biology |
David | Cortez |
Over six billion base pairs of DNA must be copied rapidly and accurately trillions of times in a human lifetime. My lab studies how this happens, the consequences of errors for human disease, and how we can intervene to improve health. We are particularly focused on how cells respond and repair DNA damage in the context of the cell division cycle. |
Keywords: DNA repair , cell cycle , DNA replication , cell signaling , cancer , genetic toxicology Cell Cycle, DNA Repair, and Chromosome Biology , Cancer Biology , Cell Signaling , Proteomics/Metabolomics , Structural Biology | |||
Timothy CoverResearch projects in the Cover laboratory are focused on bacterial infections, bacteria-host interactions, and the role of microbes in development of cancer. We are particularly interested in the bacterium Helicobacter pylori and its role as a causative agent of stomach cancer. Keywords: Bacteria-host interactions , Pathogenesis of bacterial infections , Microbe-induced cancer , Bacterial protein toxins , Bacterial protein secretion , Inflammation , Host-Pathogen Interactions , Bacteriology , Cancer Biology , Molecular Pathology , Gene Regulation , Genomics , Imaging , Immunology , Proteomics/Metabolomics , Structural Biology |
Timothy | Cover |
Research projects in the Cover laboratory are focused on bacterial infections, bacteria-host interactions, and the role of microbes in development of cancer. We are particularly interested in the bacterium Helicobacter pylori and its role as a causative agent of stomach cancer. |
Keywords: Bacteria-host interactions , Pathogenesis of bacterial infections , Microbe-induced cancer , Bacterial protein toxins , Bacterial protein secretion , Inflammation Host-Pathogen Interactions , Bacteriology , Cancer Biology , Molecular Pathology , Gene Regulation , Genomics , Imaging , Immunology , Proteomics/Metabolomics , Structural Biology | |||
Nancy CoxThe Cox lab develops methods for integrating genome variation with genome function and applies these methods in BioVU, the biobank at Vanderbilt University Medical Center. Our goal is to identify the genetic components to common human diseases and use that information to improve the health and well being of our patients. Keywords: |
Nancy | Cox |
The Cox lab develops methods for integrating genome variation with genome function and applies these methods in BioVU, the biobank at Vanderbilt University Medical Center. Our goal is to identify the genetic components to common human diseases and use that information to improve the health and well being of our patients. |
Keywords: | |||
James CroweAdvanced human immunology studies of the response to infectious diseases Keywords: Antibody engineering , Biodefense , Viruses , Immunology , Emerging infections , Antibodies and B cells , Structural Biology , Virology , Immunology |
James | Crowe |
Advanced human immunology studies of the response to infectious diseases |
Keywords: Antibody engineering , Biodefense , Viruses , Immunology , Emerging infections , Antibodies and B cells Structural Biology , Virology , Immunology | |||
Sean DaviesRole of endogenous bioactive lipids including N-acyl-ethanolamides and isolevuglandins in physiology and metabolic diseases . Role of lipids derived from gut microbiota in physiology and disease. Diseases of focus include obesity, diabetes, and cardiovascular disease. Keywords: |
Sean | Davies |
Role of endogenous bioactive lipids including N-acyl-ethanolamides and isolevuglandins in physiology and metabolic diseases . Role of lipids derived from gut microbiota in physiology and disease. Diseases of focus include obesity, diabetes, and cardiovascular disease. |
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Lea DavisIn the Davis Lab, we are driven to understand how polygenic liability, rare variant effects, and environment interact to affect the health of human populations. We study a wide range of traits including psychiatric and non-psychiatric chronic disease. Many of our projects are focused on identifying and understanding the biological and clinical linkages between mental health and physical health. Keywords: genomics , electronic health records , mental health , medical informatics , psychiatric genetics , complex disease , Computational and Systems Biology , Genomics , Developmental Neuroscience , Evolution |
Lea | Davis |
In the Davis Lab, we are driven to understand how polygenic liability, rare variant effects, and environment interact to affect the health of human populations. We study a wide range of traits including psychiatric and non-psychiatric chronic disease. Many of our projects are focused on identifying and understanding the biological and clinical linkages between mental health and physical health. |
Keywords: genomics , electronic health records , mental health , medical informatics , psychiatric genetics , complex disease Computational and Systems Biology , Genomics , Developmental Neuroscience , Evolution | |||
Mark de CaesteckerI am a physician-scientist. My research focuses on development and testing of novel therapeutics to enhance the regenerative capacity of kidneys after injury (using a Zebrafish screen and mouse models of injury), as well as the analysis of retinoic acid signaling and macrophage function after kidney injury. We have been continuously funded since 2002, and have recently been successful in obtaining a new DOD drug discovery grant to identify new therapeutic approaches to prevent chronic kidney disease progression after acute kidney injury (AKI). I am committed to teaching and mentoring in biomedical sciences. I have trained 6 PhD graduate students, 1 MD PhD and 1 Master’s student in my lab since 2000. I am a member of the Department of Cell and Developmental Biology Graduate Steering Committee and Director of the Vanderbilt Program in Molecular Medicine (VPMM). I am research area director for bench research immersion projects, which is a requirement for 3rd year medical students at Vanderbilt University Medical School. I am also Director of the Education and Outreach Program for the Vanderbilt Center for Kidney Disease, Director of the Summer Research Training Program (SRTP) in Kidney Disease, and the Vanderbilt Mouse Kidney Injury Workshop. Keywords: Kidney , Regeneration , Drug Discovery , Retinoic acid signaling , Macrophages , Injury and repair , Drug Design , Stem Cell Biology & Regeneration , Cell Signaling , Proteomics/Metabolomics |
Mark | de Caestecker |
I am a physician-scientist. My research focuses on development and testing of novel therapeutics to enhance the regenerative capacity of kidneys after injury (using a Zebrafish screen and mouse models of injury), as well as the analysis of retinoic acid signaling and macrophage function after kidney injury. We have been continuously funded since 2002, and have recently been successful in obtaining a new DOD drug discovery grant to identify new therapeutic approaches to prevent chronic kidney disease progression after acute kidney injury (AKI). I am committed to teaching and mentoring in biomedical sciences. I have trained 6 PhD graduate students, 1 MD PhD and 1 Master’s student in my lab since 2000. I am a member of the Department of Cell and Developmental Biology Graduate Steering Committee and Director of the Vanderbilt Program in Molecular Medicine (VPMM). I am research area director for bench research immersion projects, which is a requirement for 3rd year medical students at Vanderbilt University Medical School. I am also Director of the Education and Outreach Program for the Vanderbilt Center for Kidney Disease, Director of the Summer Research Training Program (SRTP) in Kidney Disease, and the Vanderbilt Mouse Kidney Injury Workshop. |
Keywords: Kidney , Regeneration , Drug Discovery , Retinoic acid signaling , Macrophages , Injury and repair Drug Design , Stem Cell Biology & Regeneration , Cell Signaling , Proteomics/Metabolomics | |||
Danielle DeanThe Dean lab seeks to understand how nutritional and other environmental factors affect pancreatic islet cell function and proliferation. Islet alpha cells secrete glucagon in response to hypoglycemia leading to increased glucose output by liver, but persons with diabetes often have hyperglucagonemia further contributing to hyperglycemia. We recently described a novel hepatic-pancreatic islet alpha cell axis that we believe is important in diabetes. We are currently interested in 1) defining the mechanism of how amino acids are sensed by alpha cells to stimulate proliferation and glucagon secretion and 2) investigating the role of amino acids on alpha cell dysfunction in diabetes. Keywords: |
Danielle | Dean |
The Dean lab seeks to understand how nutritional and other environmental factors affect pancreatic islet cell function and proliferation. Islet alpha cells secrete glucagon in response to hypoglycemia leading to increased glucose output by liver, but persons with diabetes often have hyperglucagonemia further contributing to hyperglycemia. We recently described a novel hepatic-pancreatic islet alpha cell axis that we believe is important in diabetes. We are currently interested in 1) defining the mechanism of how amino acids are sensed by alpha cells to stimulate proliferation and glucagon secretion and 2) investigating the role of amino acids on alpha cell dysfunction in diabetes. |
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Jerod DentonWe employ state-of-the-art techniques in ion channel electrophysiology and drug discovery to develop the molecular pharmacology of clinically important potassium and anion channels. Keywords: Ion channels , Electrophysiology , Structure-function analysis , Drug discovery , Physiology , Drug Design , Chemical Biology , Cell Signaling |
Jerod | Denton |
We employ state-of-the-art techniques in ion channel electrophysiology and drug discovery to develop the molecular pharmacology of clinically important potassium and anion channels. |
Keywords: Ion channels , Electrophysiology , Structure-function analysis , Drug discovery , Physiology Drug Design , Chemical Biology , Cell Signaling | |||
James DewarThe Dewar lab studies DNA replication, telomeres, and DNA damage responses. We use cell extracts that allow us to apply biochemical approaches to complex cellular processes, such as DNA replication. We aim to uncover cellular mechanisms that impact cancer and aging. Keywords: DNA replication , Telomeres , DNA repair , Biochemistry , Cancer , Aging , Cell Cycle, DNA Repair, and Chromosome Biology , Cancer Biology |
James | Dewar |
The Dewar lab studies DNA replication, telomeres, and DNA damage responses. We use cell extracts that allow us to apply biochemical approaches to complex cellular processes, such as DNA replication. We aim to uncover cellular mechanisms that impact cancer and aging. |
Keywords: DNA replication , Telomeres , DNA repair , Biochemistry , Cancer , Aging Cell Cycle, DNA Repair, and Chromosome Biology , Cancer Biology | |||
Todd EdwardsGenetic epidemiology of complex human traits using large-scale resources Keywords: genetics , epidemiology , bioinformatics , biobanks , disparities , sequencing , Computational and Systems Biology , Gene Regulation , Genomics |
Todd | Edwards |
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Genetic epidemiology of complex human traits using large-scale resources |
Keywords: genetics , epidemiology , bioinformatics , biobanks , disparities , sequencing Computational and Systems Biology , Gene Regulation , Genomics | ||
Brandt EichmanResearch in the Eichman laboratory uses X-ray crystallography and other high-resolution structural and biochemical approaches to investigate the molecular mechanisms of DNA repair and replication machines. Current work focuses on base excision repair of bacterial genotoxins and interstrand crosslinks by DNA glycosylases, repair of stalled replication forks by structure-specific DNA translocases, and priming of DNA synthesis during eukaryotic replication. Keywords: DNA repair , DNA damage , DNA replication , structural biology , X-ray crystallography , genome maintenance , Structural Biology , Cell Cycle, DNA Repair, and Chromosome Biology , Cancer Biology , Biophysics , Chemical Biology |
Brandt | Eichman |
Research in the Eichman laboratory uses X-ray crystallography and other high-resolution structural and biochemical approaches to investigate the molecular mechanisms of DNA repair and replication machines. Current work focuses on base excision repair of bacterial genotoxins and interstrand crosslinks by DNA glycosylases, repair of stalled replication forks by structure-specific DNA translocases, and priming of DNA synthesis during eukaryotic replication. |
Keywords: DNA repair , DNA damage , DNA replication , structural biology , X-ray crystallography , genome maintenance Structural Biology , Cell Cycle, DNA Repair, and Chromosome Biology , Cancer Biology , Biophysics , Chemical Biology | |||
Ronald EmesonThe research interests of our laboratory focus on the cellular and molecular processes underlying neuronal communication in normal and pathophysiologic disease states. Specifically, we are examining the molecular mechanisms involved in the editing of RNA transcripts encoding proteins critical for mammalian nervous system function. Keywords: molecular neurobiology , RNA editing , alternative splicing , neurotransmitter receptors , RNA Biology , Developmental Neuroscience |
Ronald | Emeson |
The research interests of our laboratory focus on the cellular and molecular processes underlying neuronal communication in normal and pathophysiologic disease states. Specifically, we are examining the molecular mechanisms involved in the editing of RNA transcripts encoding proteins critical for mammalian nervous system function. |
Keywords: molecular neurobiology , RNA editing , alternative splicing , neurotransmitter receptors RNA Biology , Developmental Neuroscience | |||
Kevin EssThe Ess lab does basic and translational research to study brain development and neurological dysfunction. We use several human genetic diseases as model systems. We employ human stem cell and transgenic mouse models for this work. Keywords: tuberous sclerosis , alternating hemiplegia of childhood , cortical development , iPSC , autism , epilepsy , Stem Cell Biology & Regeneration , Cardiovascular Biology , Neurodegeneration and Neuroinflamation , Developmental Neuroscience , Developmental Biology |
Kevin | Ess |
The Ess lab does basic and translational research to study brain development and neurological dysfunction. We use several human genetic diseases as model systems. We employ human stem cell and transgenic mouse models for this work. |
Keywords: tuberous sclerosis , alternating hemiplegia of childhood , cortical development , iPSC , autism , epilepsy Stem Cell Biology & Regeneration , Cardiovascular Biology , Neurodegeneration and Neuroinflamation , Developmental Neuroscience , Developmental Biology | |||
Barbara FingletonMy area of interest is understanding cancer metastasis. We are particularly interested in mechanisms that tumor cells appear to have copied from immune cells, such as using cytokine receptor signaling to alter metabolism and adapt to new environments. Keywords: breast cancer , colon cancer , mouse models , lymphatic metastasis , peptide antagonists , Drug Design , Epithelial Biology , Cancer Biology , Cancer Immunology |
Barbara | Fingleton |
My area of interest is understanding cancer metastasis. We are particularly interested in mechanisms that tumor cells appear to have copied from immune cells, such as using cytokine receptor signaling to alter metabolism and adapt to new environments. |
Keywords: breast cancer , colon cancer , mouse models , lymphatic metastasis , peptide antagonists Drug Design , Epithelial Biology , Cancer Biology , Cancer Immunology | |||
Agnes FogoOur work focuses on mechanisms of progression of chronic kidney disease. Our new work studies how even mild tubula rinjury senstizes glomeruli to a second hit. We are studying the role of changes in podocyte progenitor cells in this process, using various mice and cell culture models. Keywords: glomerulosclerosis , podocyte , crosstalk , progenitors , PAI-1 , Molecular Pathology |
Agnes | Fogo |
Our work focuses on mechanisms of progression of chronic kidney disease. Our new work studies how even mild tubula rinjury senstizes glomeruli to a second hit. We are studying the role of changes in podocyte progenitor cells in this process, using various mice and cell culture models. |
Keywords: glomerulosclerosis , podocyte , crosstalk , progenitors , PAI-1 Molecular Pathology | |||
Mike FreemanLung cancer is the largest single contributor to cancer deaths worldwide: 85% of lung cancers are classified as non-small cell lung cancer (NSCLC), and for patients who present with locally advanced stage IIB/III disease the standard of care is concurrent chemoradiation therapy. Unfortunately, this approach only yields a median survival of 17 months. Dr. Michael L. Freeman of the Department of Radiation Oncology at Vanderbilt University School of Medicine and Cumberland Emerging Technologies have partnered to develop a formulated version of a novel radio and chemo sensitizing compound that targets NPM1 for the treatment of NSCLC stage IIB/III disease. Dr. Freeman’s lab is using various approaches to develop a clinically efficacious formulation. Keywords: Non-small cell lung cancer , Radiation Therapy , Radiation Sensitization , Nucleophosmin1 , DNA double strand break repair , Drug Design , Cancer Biology |
Mike | Freeman |
Lung cancer is the largest single contributor to cancer deaths worldwide: 85% of lung cancers are classified as non-small cell lung cancer (NSCLC), and for patients who present with locally advanced stage IIB/III disease the standard of care is concurrent chemoradiation therapy. Unfortunately, this approach only yields a median survival of 17 months. Dr. Michael L. Freeman of the Department of Radiation Oncology at Vanderbilt University School of Medicine and Cumberland Emerging Technologies have partnered to develop a formulated version of a novel radio and chemo sensitizing compound that targets NPM1 for the treatment of NSCLC stage IIB/III disease. Dr. Freeman’s lab is using various approaches to develop a clinically efficacious formulation. |
Keywords: Non-small cell lung cancer , Radiation Therapy , Radiation Sensitization , Nucleophosmin1 , DNA double strand break repair Drug Design , Cancer Biology | |||
Katherine FriedmanThe Friedman lab uses the yeast Saccharomyces cerevisiae as a model system to study basic mechanisms of DNA replication and DNA repair, with a particular emphasis on telomere biology. We use genetic and biochemical approaches to identify regulatory mechanisms affecting DNA repair pathway choice at double-strand breaks. Recent work has identified sites in the yeast genome that serve as “hotspots” of de novo telomere addition following a chromosome break. Keywords: DNA replication , DNA repair , Telomere , Telomerase , Non-homologous End joining , Yeast , Cell Cycle, DNA Repair, and Chromosome Biology , Cancer Biology |
Katherine | Friedman |
The Friedman lab uses the yeast Saccharomyces cerevisiae as a model system to study basic mechanisms of DNA replication and DNA repair, with a particular emphasis on telomere biology. We use genetic and biochemical approaches to identify regulatory mechanisms affecting DNA repair pathway choice at double-strand breaks. Recent work has identified sites in the yeast genome that serve as “hotspots” of de novo telomere addition following a chromosome break. |
Keywords: DNA replication , DNA repair , Telomere , Telomerase , Non-homologous End joining , Yeast Cell Cycle, DNA Repair, and Chromosome Biology , Cancer Biology | |||
Sabine FuhrmannWe use mouse models to study the role of signaling pathways on formation, differentiation and morphogenesis of the developing eye. Another focus in the lab is ocular regeneration; we are determining the molecular and cellular mechanisms controlling the regenerative capacity of the retinal pigment epithelium. Among other pathways, we are specifically studying the role of Wnt signaling during development and regeneration. Keywords: eye , development , regeneration , wnt , retinal pigment epithelium , Stem Cell Biology & Regeneration , Cell Signaling , Visual Sciences , Developmental Neuroscience , Developmental Biology |
Sabine | Fuhrmann |
We use mouse models to study the role of signaling pathways on formation, differentiation and morphogenesis of the developing eye. Another focus in the lab is ocular regeneration; we are determining the molecular and cellular mechanisms controlling the regenerative capacity of the retinal pigment epithelium. Among other pathways, we are specifically studying the role of Wnt signaling during development and regeneration. |
Keywords: eye , development , regeneration , wnt , retinal pigment epithelium Stem Cell Biology & Regeneration , Cell Signaling , Visual Sciences , Developmental Neuroscience , Developmental Biology | |||
Vivian GamaOur research program aims to reveal new molecular mechanisms involved in regulating cell fate. The lab focuses on three main lines of research: 1) Mechanisms by which mitochondrial biology regulates normal and cancer stem cell fate – role of the BCL-2 family of proteins modulating mitochondrial morphology/function, stem cell self-renewal, pluripotency and differentiation; 2) Examining the role of MCL-1 in early human neural development using three dimensional systems (embryoid bodies, neural rosettes and brain organoids; 3) Function of the ubiquitin ligase CUL9 in the transition from a stem cell to a neural progenitor cell. Keywords: stem cells , mitochondrial dynamics , neural stem cells , brain organoids , apoptosis , mitochondria , Stem Cell Biology & Regeneration , Cancer Biology , Developmental Neuroscience , Developmental Biology |
Vivian | Gama |
Our research program aims to reveal new molecular mechanisms involved in regulating cell fate. The lab focuses on three main lines of research: 1) Mechanisms by which mitochondrial biology regulates normal and cancer stem cell fate – role of the BCL-2 family of proteins modulating mitochondrial morphology/function, stem cell self-renewal, pluripotency and differentiation; 2) Examining the role of MCL-1 in early human neural development using three dimensional systems (embryoid bodies, neural rosettes and brain organoids; 3) Function of the ubiquitin ligase CUL9 in the transition from a stem cell to a neural progenitor cell. |
Keywords: stem cells , mitochondrial dynamics , neural stem cells , brain organoids , apoptosis , mitochondria Stem Cell Biology & Regeneration , Cancer Biology , Developmental Neuroscience , Developmental Biology | |||
Maureen GannonOur laboratory studies transcription factors and signaling pathways that regulate the differentiation, proliferation, survival, and function of the different cell types in the pancreas. We use genetically engineered mouse models, as well as primary pancreatic cells from non-human primates and human donors. Our studies have implications for diseases such as diabetes and pancreatic cancer. Keywords: developmental biology , diabetes , physiology , organogenesis , cell signaling , gene regulation , Diabetes, Obesity, Metabolism , Gene Regulation , Cancer Biology , Cell Signaling , Developmental Biology |
Maureen | Gannon |
Our laboratory studies transcription factors and signaling pathways that regulate the differentiation, proliferation, survival, and function of the different cell types in the pancreas. We use genetically engineered mouse models, as well as primary pancreatic cells from non-human primates and human donors. Our studies have implications for diseases such as diabetes and pancreatic cancer. |
Keywords: developmental biology , diabetes , physiology , organogenesis , cell signaling , gene regulation Diabetes, Obesity, Metabolism , Gene Regulation , Cancer Biology , Cell Signaling , Developmental Biology | |||
Ivelin GeorgievAt the interface of immunology and virology, recent computational advances have allowed us to better understand the interactions between antibodies and antigen, to design immunogens capable of eliciting target antibody specificities, and to optimize antibodies as clinical products. Research efforts in the Georgiev laboratory aim to utilize the power of computation to increase our understanding of fundamental questions in immunology and virology and to develop novel ways of using this understanding to fight diseases. For the translational component of our research, we apply structure-based protein design approaches to the development of new vaccine and antibody product candidates against a number of viruses of biomedical interest. Keywords: computational science , immunology , vaccines , viruses , antibodies , Structural Biology , Computational and Systems Biology , Virology , Immunology |
Ivelin | Georgiev |
At the interface of immunology and virology, recent computational advances have allowed us to better understand the interactions between antibodies and antigen, to design immunogens capable of eliciting target antibody specificities, and to optimize antibodies as clinical products. Research efforts in the Georgiev laboratory aim to utilize the power of computation to increase our understanding of fundamental questions in immunology and virology and to develop novel ways of using this understanding to fight diseases. For the translational component of our research, we apply structure-based protein design approaches to the development of new vaccine and antibody product candidates against a number of viruses of biomedical interest. |
Keywords: computational science , immunology , vaccines , viruses , antibodies Structural Biology , Computational and Systems Biology , Virology , Immunology | |||
Todd GiorgioThe Giorgio lab conducts curiosity-driven research focused on important unmet needs aligned with our capabilities and interests. Our projects are interdisciplinary and we engage collaborators with synergistic expertise and compatible approaches. We are currently developing new materials for modulation of immunity and devices for sensing and pathogen extraction. Keywords: biomaterials for gene and drug delivery , cancer immunomodulation , modulation of immune tolerance in lupus , nanostructured materials for surface enhanced Raman spectroscopy , discovery of olfactory receptor involvement in breast cancer , sensing and extraction of blood-borne pathogens , Drug Design , Immunology , Cancer Biology , Cancer Immunology |
Todd | Giorgio |
The Giorgio lab conducts curiosity-driven research focused on important unmet needs aligned with our capabilities and interests. Our projects are interdisciplinary and we engage collaborators with synergistic expertise and compatible approaches. We are currently developing new materials for modulation of immunity and devices for sensing and pathogen extraction. |
Keywords: biomaterials for gene and drug delivery , cancer immunomodulation , modulation of immune tolerance in lupus , nanostructured materials for surface enhanced Raman spectroscopy , discovery of olfactory receptor involvement in breast cancer , sensing and extraction of blood-borne pathogens Drug Design , Immunology , Cancer Biology , Cancer Immunology | |||
Jeremy GoettelOur lab is interested in understanding the mechanisms regulating intestinal immunity and what leads to dysregulation and disease as well as how gut microbes shape the mucosal immune system. In particular the cytokine interleukin-23 (IL23) is required for the development of many experimental models of inflammatory bowel disease (IBD) in mice and mutations in IL23 receptor (IL23R) have been identified as susceptibility or resistance factors for Crohn’s disease. We have developed several murine strains that will facilitate investigations into the role of IL23R signaling in a cell-specific manner using experimental models of IBD and inflammation-associated carcinogenesis. Keywords: IBD , Mucosal Immunity , Cancer , T cells , Microbiome , Host-Pathogen Interactions , Immunology , Cancer Biology , Cancer Immunology , Molecular Pathology |
Jeremy | Goettel |
Our lab is interested in understanding the mechanisms regulating intestinal immunity and what leads to dysregulation and disease as well as how gut microbes shape the mucosal immune system. In particular the cytokine interleukin-23 (IL23) is required for the development of many experimental models of inflammatory bowel disease (IBD) in mice and mutations in IL23 receptor (IL23R) have been identified as susceptibility or resistance factors for Crohn’s disease. We have developed several murine strains that will facilitate investigations into the role of IL23R signaling in a cell-specific manner using experimental models of IBD and inflammation-associated carcinogenesis. |
Keywords: IBD , Mucosal Immunity , Cancer , T cells , Microbiome Host-Pathogen Interactions , Immunology , Cancer Biology , Cancer Immunology , Molecular Pathology | |||
James GoldenringThe Goldenring lab has multiple interests in Epithelial Biology and Cancer biology including 1) the role of membrane trafficking and recycling in polarity, 2) the cellular basis of congenital diarrheas, 3) the cell of origin for pre-cancerous metaplasia in the stomach and the immune cell drivers of stomach carcinogenesis and 4) the role of AKAP350 in organizing the pericentrosomal material. Keywords: Vesicle trafficking , Metaplasia , congenital Diarrhea , centrosome , membrane recycling , carcinogenesis , gastric cancer , Rab proteins , Epithelial Biology , Cancer Biology , Molecular Pathology , Cancer Immunology , Cell Signaling , Cell Structure , Stem Cell Biology & Regeneration |
James | Goldenring |
The Goldenring lab has multiple interests in Epithelial Biology and Cancer biology including 1) the role of membrane trafficking and recycling in polarity, 2) the cellular basis of congenital diarrheas, 3) the cell of origin for pre-cancerous metaplasia in the stomach and the immune cell drivers of stomach carcinogenesis and 4) the role of AKAP350 in organizing the pericentrosomal material. |
Keywords: Vesicle trafficking , Metaplasia , congenital Diarrhea , centrosome , membrane recycling , carcinogenesis , gastric cancer , Rab proteins Epithelial Biology , Cancer Biology , Molecular Pathology , Cancer Immunology , Cell Signaling , Cell Structure , Stem Cell Biology & Regeneration | |||
John GoreDevelopment and applications of magnetic resonance imaging for neuroscience applications including understanding the biophysical basis of functional MRI and diffusion MRI of brain and spinal cord. Integration of MRI and electrophysiology and other techniques to understand brain function in rodents and non-human primates. Basic physics of MRI signals and physiological factors affecting MR images. Keywords: imaging physics , MRI , neuroscience , brain function , spinal cord , imaging biomarkers , Imaging |
John | Gore |
Development and applications of magnetic resonance imaging for neuroscience applications including understanding the biophysical basis of functional MRI and diffusion MRI of brain and spinal cord. Integration of MRI and electrophysiology and other techniques to understand brain function in rodents and non-human primates. Basic physics of MRI signals and physiological factors affecting MR images. |
Keywords: imaging physics , MRI , neuroscience , brain function , spinal cord , imaging biomarkers Imaging | |||
Kathleen GouldThe Gould laboratory conducts foundational research on the molecular basis of cell division, a highly conserved process central to development and tissue maintenance. The laboratory takes a multi-disciplinary approach employing genetics, biochemistry, phosphoproteomics, and microscopy. Our ultimate goal is to obtain a comprehensive mechanistic understanding of the exquisite spatial and temporal control of cell division in eukaryotes. Keywords: cell division , cell cycle , intracellular signaling , protein kinases , phosphoproteomics , live cell imaging , Imaging , Cell Cycle, DNA Repair, and Chromosome Biology , Cancer Biology , Proteomics/Metabolomics , Cell Structure |
Kathleen | Gould |
The Gould laboratory conducts foundational research on the molecular basis of cell division, a highly conserved process central to development and tissue maintenance. The laboratory takes a multi-disciplinary approach employing genetics, biochemistry, phosphoproteomics, and microscopy. Our ultimate goal is to obtain a comprehensive mechanistic understanding of the exquisite spatial and temporal control of cell division in eukaryotes. |
Keywords: cell division , cell cycle , intracellular signaling , protein kinases , phosphoproteomics , live cell imaging Imaging , Cell Cycle, DNA Repair, and Chromosome Biology , Cancer Biology , Proteomics/Metabolomics , Cell Structure | |||
Todd GrahamThe research goals of the Graham laboratory are to understand the molecular mechanisms underpinning vesicle-mediated protein transport and membrane biogenesis. Defects in these processes lead to a number of human diseases, including diabetes, cardiovascular disease, neurodegenerative diseases and cancer. Keywords: |
Todd | Graham |
The research goals of the Graham laboratory are to understand the molecular mechanisms underpinning vesicle-mediated protein transport and membrane biogenesis. Defects in these processes lead to a number of human diseases, including diabetes, cardiovascular disease, neurodegenerative diseases and cancer. |
Keywords: | |||
Brad GrueterThe goal of the Grueter lab research program is to advance the current understanding of the nucleus accumbens (NAc), a brain region responsible for integrating information from diverse inputs and modifying complex motivated behaviors, including its involvement in adaptive responses to rewarding and aversive stimuli. Specifically, we strive to elucidate the molecular constituents in the NAc that are necessary and sufficient to drive complex motivated behaviors. Keywords: nucleus accumbens , synapses , synaptic plasticity , brain reward circuits , electrophysiology , neuroscience , Cell Signaling , Synaptic Function and Neuroendocrinology |
Brad | Grueter |
The goal of the Grueter lab research program is to advance the current understanding of the nucleus accumbens (NAc), a brain region responsible for integrating information from diverse inputs and modifying complex motivated behaviors, including its involvement in adaptive responses to rewarding and aversive stimuli. Specifically, we strive to elucidate the molecular constituents in the NAc that are necessary and sufficient to drive complex motivated behaviors. |
Keywords: nucleus accumbens , synapses , synaptic plasticity , brain reward circuits , electrophysiology , neuroscience Cell Signaling , Synaptic Function and Neuroendocrinology | |||
Guoqiang GuWe study how organisms made optimally functional beta cells to reduce the risks of diabetes. Our focuses are the genetic pathways and epigenetic modifications involved in the process. We use mouse models and human islets for our studies.
Keywords: Diabetes , beta-cell development , beta-cell proliferation and survival , stress response , insulin transport and secretion , beta-cell aging , Developmental Biology , Diabetes, Obesity, Metabolism , Gene Regulation , Genomics , Imaging , RNA Biology , Stem Cell Biology & Regeneration |
Guoqiang | Gu |
We study how organisms made optimally functional beta cells to reduce the risks of diabetes. Our focuses are the genetic pathways and epigenetic modifications involved in the process. We use mouse models and human islets for our studies.
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Keywords: Diabetes , beta-cell development , beta-cell proliferation and survival , stress response , insulin transport and secretion , beta-cell aging Developmental Biology , Diabetes, Obesity, Metabolism , Gene Regulation , Genomics , Imaging , RNA Biology , Stem Cell Biology & Regeneration | |||
Scott GuelcherThe Guelcher laboratory designs and develops biomaterials and drug delivery systems that enhance healing of tissue damaged by trauma or disease. Current projects include design of injectable tissue grafts for healing bone in challenging environments, including weight-bearing anatomic sites, defects contaminated by bacteria, and large tissue voids resulting from extremity and craniofacial trauma. Keywords: bone , regenerative medicine , 3D printing , biomaterials , drug delivery , biomechanics , Drug Design , Stem Cell Biology & Regeneration , Cancer Biology , Molecular Pathology |
Scott | Guelcher |
The Guelcher laboratory designs and develops biomaterials and drug delivery systems that enhance healing of tissue damaged by trauma or disease. Current projects include design of injectable tissue grafts for healing bone in challenging environments, including weight-bearing anatomic sites, defects contaminated by bacteria, and large tissue voids resulting from extremity and craniofacial trauma. |
Keywords: bone , regenerative medicine , 3D printing , biomaterials , drug delivery , biomechanics Drug Design , Stem Cell Biology & Regeneration , Cancer Biology , Molecular Pathology | |||
F. Peter GuengerichThe Guengerich laboratory is interested in the enzymes involved in the activation and processing of xenobiotic chemicals (i.e., those not normally found in the body, such as drugs and carcinogens), as well as steroids and vitamins. The work is focused on the enzymology of two major groups of enzymes, cytochromes P450 and DNA polymerases. Keywords: Cytochrome P450 , DNA polymerases , Enzyme kinetics , Mass spectrometry , Proteomics , Metabolomics , Diabetes, Obesity, Metabolism , Chemical Biology , Proteomics/Metabolomics |
F. Peter | Guengerich |
The Guengerich laboratory is interested in the enzymes involved in the activation and processing of xenobiotic chemicals (i.e., those not normally found in the body, such as drugs and carcinogens), as well as steroids and vitamins. The work is focused on the enzymology of two major groups of enzymes, cytochromes P450 and DNA polymerases. |
Keywords: Cytochrome P450 , DNA polymerases , Enzyme kinetics , Mass spectrometry , Proteomics , Metabolomics Diabetes, Obesity, Metabolism , Chemical Biology , Proteomics/Metabolomics | |||
Eugenia GurevichWe are studying the role of the signaling mechanisms regulated by G protein-coupled receptor kinases and arrestins in brain diseases. Keywords: Parkinson's disease , drug addiction , G protein-coupled receptors , receptor desensitization , signaling , Structural Biology , Drug Design , Cell Signaling , Visual Sciences , Neurodegeneration and Neuroinflamation |
Eugenia | Gurevich |
We are studying the role of the signaling mechanisms regulated by G protein-coupled receptor kinases and arrestins in brain diseases. |
Keywords: Parkinson's disease , drug addiction , G protein-coupled receptors , receptor desensitization , signaling Structural Biology , Drug Design , Cell Signaling , Visual Sciences , Neurodegeneration and Neuroinflamation | |||
Vsevolod GurevichWe study structure and biological functions of arrestin proteins. Arrestins are key regulators of G protein-coupled receptor signaling and several receptor-independent pathways that affect life and death of cells. Our ultimate goal is to create designer arrestins that bind the receptors we want and activate the pathways of our choosing. Keywords: arrestin , structure , G protein-coupled receptors , cell signaling , cell proliferation , cell death , Structural Biology , Drug Design , Cell Signaling , Visual Sciences , Neurodegeneration and Neuroinflamation |
Vsevolod | Gurevich |
We study structure and biological functions of arrestin proteins. Arrestins are key regulators of G protein-coupled receptor signaling and several receptor-independent pathways that affect life and death of cells. Our ultimate goal is to create designer arrestins that bind the receptors we want and activate the pathways of our choosing. |
Keywords: arrestin , structure , G protein-coupled receptors , cell signaling , cell proliferation , cell death Structural Biology , Drug Design , Cell Signaling , Visual Sciences , Neurodegeneration and Neuroinflamation | |||
Heidi HammWe study G protein signaling in mouse brains and human platelets. Current projects relate to G protein coupled receptor pharmacology and signaling. We seek to discover small molecules that inhibit the protease-activated receptor PAR4 for antiplatelet and antithrombotic therapy. We also study regulation of secretion by Gi/o-coupled receptors and Gbg. We have discovered a novel interaction between Gbg and the SNARE complex and have generated a mouse that disables this interaction. Phenotyping this mouse has given us insight into the role of Gbg SNARE interaction and inhibition of exocytosis in metabolism and physiology. Keywords: G proteins , G protein coupled receptors , regulation of exocytosis , SNARE complex , Protease Activated Receptor-4 in platelets , drug discovery , Drug Design , Cardiovascular Biology , Cell Signaling , Visual Sciences |
Heidi | Hamm |
We study G protein signaling in mouse brains and human platelets. Current projects relate to G protein coupled receptor pharmacology and signaling. We seek to discover small molecules that inhibit the protease-activated receptor PAR4 for antiplatelet and antithrombotic therapy. We also study regulation of secretion by Gi/o-coupled receptors and Gbg. We have discovered a novel interaction between Gbg and the SNARE complex and have generated a mouse that disables this interaction. Phenotyping this mouse has given us insight into the role of Gbg SNARE interaction and inhibition of exocytosis in metabolism and physiology. |
Keywords: G proteins , G protein coupled receptors , regulation of exocytosis , SNARE complex , Protease Activated Receptor-4 in platelets , drug discovery Drug Design , Cardiovascular Biology , Cell Signaling , Visual Sciences | |||
Fiona HarrisonNutritional factors that impact Alzheimer’s disease pathogenesis, including high fat diet and vitamin C deficiency. The lab uses behavioral and molecular biochemical methods to study altered learning and memory in a range of mutant mouse models. Keywords: Behavior , Oxidative stress , Alzheimer's disease , Vitamin C , Aging , Mouse , Diabetes, Obesity, Metabolism , Molecular Pathology , Neurodegeneration and Neuroinflamation |
Fiona | Harrison |
Nutritional factors that impact Alzheimer’s disease pathogenesis, including high fat diet and vitamin C deficiency. The lab uses behavioral and molecular biochemical methods to study altered learning and memory in a range of mutant mouse models. |
Keywords: Behavior , Oxidative stress , Alzheimer's disease , Vitamin C , Aging , Mouse Diabetes, Obesity, Metabolism , Molecular Pathology , Neurodegeneration and Neuroinflamation | |||
Alyssa HastyWe study how obesity impacts health. The growing worldwide obesity epidemic is frequently linked to hyperlipidemia, inflammation, and insulin resistance leading to increased risk of diabetes and cardiovascular disease. The long-term goal of our laboratory is to determine mechanisms by which obesity increases risk for and pathophysiological consequences of these devastating diseases. Macrophages are part of the innate immune system that infiltrate white adipose tissue (fat) in obese rodents and humans, and produce most of the inflammatory cytokines and chemokines secreted from adipose tissue. In addition, their presence has been shown to be temporally associated with the development of insulin resistance. Our current research focus is threefold: to determine mechanisms by which macrophages accumulate in adipose tissue, to determine the role of resident macrophages in normal adipose tissue function, and to determine how other immune cells like eosinophils and T cells also contribute to adipose tissue function. Keywords: obesity , immune system , macrophage , Immunity , immunometabolism , iron , adipose tissue , diabetes , Diabetes, Obesity, Metabolism , Immunology , Molecular Pathology |
Alyssa | Hasty |
We study how obesity impacts health. The growing worldwide obesity epidemic is frequently linked to hyperlipidemia, inflammation, and insulin resistance leading to increased risk of diabetes and cardiovascular disease. The long-term goal of our laboratory is to determine mechanisms by which obesity increases risk for and pathophysiological consequences of these devastating diseases. Macrophages are part of the innate immune system that infiltrate white adipose tissue (fat) in obese rodents and humans, and produce most of the inflammatory cytokines and chemokines secreted from adipose tissue. In addition, their presence has been shown to be temporally associated with the development of insulin resistance. Our current research focus is threefold: to determine mechanisms by which macrophages accumulate in adipose tissue, to determine the role of resident macrophages in normal adipose tissue function, and to determine how other immune cells like eosinophils and T cells also contribute to adipose tissue function. |
Keywords: obesity , immune system , macrophage , Immunity , immunometabolism , iron , adipose tissue , diabetes Diabetes, Obesity, Metabolism , Immunology , Molecular Pathology | |||
Antonis HatzopoulosMy laboratory studies molecular and cellular mechanisms of cardiac tissue repair after myocardial infarction and in diabetic cardiomyopathy. At the cellular level, we investigate the role of endothelial and cardiovascular stem cells in tissue repair and regeneration. At the molecular level, we focus on the role of BMP signaling in inflammation after injury and in the growth and differentiation of various adult stem cell populations. Keywords: Pluripotent stem cells , Heart attack , Diabetic cardiomyopathy , cardiac regeneration , BMP signaling , Wnt signaling , Myocardial infarction , Tissue repair and regeneration , Diabetes, Obesity, Metabolism , Stem Cell Biology & Regeneration , Cardiovascular Biology , Cell Signaling , Developmental Biology , Computational and Systems Biology , Genomics , Vascular Biology |
Antonis | Hatzopoulos |
My laboratory studies molecular and cellular mechanisms of cardiac tissue repair after myocardial infarction and in diabetic cardiomyopathy. At the cellular level, we investigate the role of endothelial and cardiovascular stem cells in tissue repair and regeneration. At the molecular level, we focus on the role of BMP signaling in inflammation after injury and in the growth and differentiation of various adult stem cell populations. |
Keywords: Pluripotent stem cells , Heart attack , Diabetic cardiomyopathy , cardiac regeneration , BMP signaling , Wnt signaling , Myocardial infarction , Tissue repair and regeneration Diabetes, Obesity, Metabolism , Stem Cell Biology & Regeneration , Cardiovascular Biology , Cell Signaling , Developmental Biology , Computational and Systems Biology , Genomics , Vascular Biology | |||
Jennifer HeringtonOur research is focused on interventional approaches to regulate uterine contractions for either the management of preterm labor or postpartum hemorrhage. Our laboratory has established a drug discovery strategy to identifying novel regulators of uterine myometrial contractility. We are equipped for high-throughput screening of small-molecules, prioritization of hits into leads using secondary assays and pre-clinical in vivo testing in mouse models. Keywords: drug discovery , pregnancy , women's health , high-throughput screening , drug repurposing , Chemical Biology , Molecular Pathology |
Jennifer | Herington |
Our research is focused on interventional approaches to regulate uterine contractions for either the management of preterm labor or postpartum hemorrhage. Our laboratory has established a drug discovery strategy to identifying novel regulators of uterine myometrial contractility. We are equipped for high-throughput screening of small-molecules, prioritization of hits into leads using secondary assays and pre-clinical in vivo testing in mouse models. |
Keywords: drug discovery , pregnancy , women's health , high-throughput screening , drug repurposing Chemical Biology , Molecular Pathology | |||
Scott HiebertUsing CRISPRs coupled with HDR DNA repair to engineer endogenous genes for deep genomic and proteomic analysis. This allows us to define transcription targets and networks for mechanistic studies. Keywords: Cancer Biology , Gene expression , nascent transcription , chemical genetics , chromatin , enhancer functions , Cancer Biology , Cell Cycle, DNA Repair, and Chromosome Biology , Cell Signaling , Chemical Biology , Computational and Systems Biology , Developmental Biology , Gene Regulation , Genomics , Imaging , Proteomics/Metabolomics , Stem Cell Biology & Regeneration , Virology |
Scott | Hiebert |
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Using CRISPRs coupled with HDR DNA repair to engineer endogenous genes for deep genomic and proteomic analysis. This allows us to define transcription targets and networks for mechanistic studies. |
Keywords: Cancer Biology , Gene expression , nascent transcription , chemical genetics , chromatin , enhancer functions Cancer Biology , Cell Cycle, DNA Repair, and Chromosome Biology , Cell Signaling , Chemical Biology , Computational and Systems Biology , Developmental Biology , Gene Regulation , Genomics , Imaging , Proteomics/Metabolomics , Stem Cell Biology & Regeneration , Virology | ||
Julian HillyerThe Hillyer Lab investigates aspects of mosquito immunology and physiology related to their ability to transmit diseases such as malaria. The lab focuses on the mechanical and molecular bases of hemolymph (blood) propulsion, the immunological interaction between mosquitoes and pathogens in the hemocoel (body cavity), and the effect of life history on immune competence. Keywords: |
Julian | Hillyer |
The Hillyer Lab investigates aspects of mosquito immunology and physiology related to their ability to transmit diseases such as malaria. The lab focuses on the mechanical and molecular bases of hemolymph (blood) propulsion, the immunological interaction between mosquitoes and pathogens in the hemocoel (body cavity), and the effect of life history on immune competence. |
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Antentor Hinton, Jr.The Hinton Lab utilizes SBF-SEM and FIB-SEM to investigate the molecular mechanisms that regulate molecule transfer and morphology changes between the mitochondria and the endoplasmic reticulum and how these mechanisms are altered during pathophysiological states diabetes, obesity, and cardiovascular disease.
Keywords: Mitochondria , Mitochondria Endoplasmic Reticulum Contact Sites , Transmission Electron Microscopy , Serial Block Face (SBF) Scanning Electron Microscopy , Focus Ion Beam (FIB) Scanning Electron Microscopy , TMEM 135 & MICOS , Biophysics , Cancer Immunology , Cell Signaling , Cell Structure , Diabetes, Obesity, Metabolism , Synaptic Function & Neuroendocrinology |
Antentor | Hinton, Jr. |
The Hinton Lab utilizes SBF-SEM and FIB-SEM to investigate the molecular mechanisms that regulate molecule transfer and morphology changes between the mitochondria and the endoplasmic reticulum and how these mechanisms are altered during pathophysiological states diabetes, obesity, and cardiovascular disease.
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Keywords: Mitochondria , Mitochondria Endoplasmic Reticulum Contact Sites , Transmission Electron Microscopy , Serial Block Face (SBF) Scanning Electron Microscopy , Focus Ion Beam (FIB) Scanning Electron Microscopy , TMEM 135 & MICOS Biophysics , Cancer Immunology , Cell Signaling , Cell Structure , Diabetes, Obesity, Metabolism , Synaptic Function & Neuroendocrinology | |||
Emily HodgesPrimary research in the Hodges lab is focused on DNA methylation and non-coding gene regulatory variation in evolution, development and disease. In particular, we study dynamic changes in the epigenome during cellular fate transitions using innovative genomic and bioinformatic approaches. Keywords: Epigenetics , Functional Genomics , DNA Methylation , Stem cell development , Bioinformatics , Next-Gen Sequencing , Cellular Differentiation , Non-coding Gene Regulation , Computational and Systems Biology , Stem Cell Biology & Regeneration , Genomics , Developmental Biology , Cancer Biology , Gene Regulation |
Emily | Hodges |
Primary research in the Hodges lab is focused on DNA methylation and non-coding gene regulatory variation in evolution, development and disease. In particular, we study dynamic changes in the epigenome during cellular fate transitions using innovative genomic and bioinformatic approaches. |
Keywords: Epigenetics , Functional Genomics , DNA Methylation , Stem cell development , Bioinformatics , Next-Gen Sequencing , Cellular Differentiation , Non-coding Gene Regulation Computational and Systems Biology , Stem Cell Biology & Regeneration , Genomics , Developmental Biology , Cancer Biology , Gene Regulation | |||
Timothy HohmanThe Computational Neurogenomics lab leverages advanced statistical approaches and computational ‘omics to identify novel treatment targets for Alzheimer’s disease (AD). We primarily focus on identifying the molecular drivers of resilience to AD, and identifying sex-specific genetic predictors of AD. Keywords: Genomics , Alzheimer's Disease , Neuroimaging , Biomarkers , Computational Neuroscience , Data Science , Computational and Systems Biology , Imaging , Genomics , Neurodegeneration and Neuroinflamation , Proteomics/Metabolomics |
Timothy | Hohman |
The Computational Neurogenomics lab leverages advanced statistical approaches and computational ‘omics to identify novel treatment targets for Alzheimer’s disease (AD). We primarily focus on identifying the molecular drivers of resilience to AD, and identifying sex-specific genetic predictors of AD. |
Keywords: Genomics , Alzheimer's Disease , Neuroimaging , Biomarkers , Computational Neuroscience , Data Science Computational and Systems Biology , Imaging , Genomics , Neurodegeneration and Neuroinflamation , Proteomics/Metabolomics | |||
Patrick HuAging is the major risk factor for common illnesses that account for most human morbidity and mortality. My lab uses the nematode Caenorhabditis elegans to study the role of a conserved insulin-like growth factor signaling pathway in development, metabolism, and aging. We seek to reveal insights into basic mechanisms of aging that may lead to new strategies to prevent and manage prevalent diseases such as diabetes and cancer. Keywords: C. elegans , development , aging , insulin-like growth factors , signal transduction , FoxO transcription factors , Diabetes, Obesity, Metabolism , Cancer Biology , Cardiovascular Biology , Molecular Pathology , Cell Signaling |
Patrick | Hu |
Aging is the major risk factor for common illnesses that account for most human morbidity and mortality. My lab uses the nematode Caenorhabditis elegans to study the role of a conserved insulin-like growth factor signaling pathway in development, metabolism, and aging. We seek to reveal insights into basic mechanisms of aging that may lead to new strategies to prevent and manage prevalent diseases such as diabetes and cancer. |
Keywords: C. elegans , development , aging , insulin-like growth factors , signal transduction , FoxO transcription factors Diabetes, Obesity, Metabolism , Cancer Biology , Cardiovascular Biology , Molecular Pathology , Cell Signaling | |||
Paula HurleyThe goal of our laboratory is to reduce the death and suffering caused by prostate cancer. Cancer localized to the prostate is often curable with treatments such as surgery or radiation therapy; however, once prostate cancer has spread beyond the prostate to other organs or to bone, it is an incurable disease. Our lab focuses on identifying both cancer cell-autonomous and non-cancer cell-autonomous genetic and molecular pathways that promote lethal prostate cancer and cause therapy resistance. Keywords: |
Paula | Hurley |
The goal of our laboratory is to reduce the death and suffering caused by prostate cancer. Cancer localized to the prostate is often curable with treatments such as surgery or radiation therapy; however, once prostate cancer has spread beyond the prostate to other organs or to bone, it is an incurable disease. Our lab focuses on identifying both cancer cell-autonomous and non-cancer cell-autonomous genetic and molecular pathways that promote lethal prostate cancer and cause therapy resistance. |
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Shane HutsonThe Hutson lab is interested in understanding the cell-level forces that drive epithelial morphogenesis and wound healing. Current projects include the following: measurement of cellular forces in vivo — both via laser manipulations and image-based force inference; understanding how these forces are perturbed after exposure to chemicals with developmental toxicity; and investigations of the calcium signaling pathways by which cells detect and respond to wounds. Projects include both experimental and computational approaches. Keywords: morphogenesis , mechanics , computational modeling , laser ablation , toxicology , Drosophila , Biophysics , Computational and Systems Biology , Epithelial Biology , Cell Signaling |
Shane | Hutson |
The Hutson lab is interested in understanding the cell-level forces that drive epithelial morphogenesis and wound healing. Current projects include the following: measurement of cellular forces in vivo — both via laser manipulations and image-based force inference; understanding how these forces are perturbed after exposure to chemicals with developmental toxicity; and investigations of the calcium signaling pathways by which cells detect and respond to wounds. Projects include both experimental and computational approaches. |
Keywords: morphogenesis , mechanics , computational modeling , laser ablation , toxicology , Drosophila Biophysics , Computational and Systems Biology , Epithelial Biology , Cell Signaling | |||
Rebecca IhrieWe use imaging and flow cytometry to understand the signaling events driving normal stem cell commitment in the brain and the disruption of this process in disease. We work in animal models and in human tissue specimens to directly study neural stem cells and brain tumors of all grades. Keywords: Stem Cells , Brain Tumors , Developmental Biology , Systems Biology , Signal Transduction , Computational and Systems Biology , Stem Cell Biology & Regeneration , Cancer Biology , Cell Signaling , Developmental Neuroscience , Developmental Biology |
Rebecca | Ihrie |
We use imaging and flow cytometry to understand the signaling events driving normal stem cell commitment in the brain and the disruption of this process in disease. We work in animal models and in human tissue specimens to directly study neural stem cells and brain tumors of all grades. |
Keywords: Stem Cells , Brain Tumors , Developmental Biology , Systems Biology , Signal Transduction Computational and Systems Biology , Stem Cell Biology & Regeneration , Cancer Biology , Cell Signaling , Developmental Neuroscience , Developmental Biology | |||
Jonathan IrishGraduate thesis projects in the Irish lab are tailored to fit student interests. Active research areas include: (1) programming immune cell identity, (2) computational biology & machine learning cell identity, and (3) neural stem cells, neuroimmunology, and brain tumors. Graduate projects may be entirely computational, basic cell biology, or human disease oriented, although most projects blend all these elements. Rotations begin with training in relevant technologies, such as mass cytometry (CyTOF), computational tools, and methods for human tissue research. Graduate students craft their projects in regular mentoring meetings with Dr. Irish and are supported by a team science environment including expert lab staff, postdocs, clinical fellows, and collaborators at Vanderbilt and institutions around the world. Keywords: human cell biology , cancer precision medicine , machine learning , cell signaling , neuroimmunology , tumor immunology , Computational and Systems Biology , Stem Cell Biology & Regeneration , Immunology , Cancer Immunology , Cell Signaling , Developmental Neuroscience |
Jonathan | Irish |
Graduate thesis projects in the Irish lab are tailored to fit student interests. Active research areas include: (1) programming immune cell identity, (2) computational biology & machine learning cell identity, and (3) neural stem cells, neuroimmunology, and brain tumors. Graduate projects may be entirely computational, basic cell biology, or human disease oriented, although most projects blend all these elements. Rotations begin with training in relevant technologies, such as mass cytometry (CyTOF), computational tools, and methods for human tissue research. Graduate students craft their projects in regular mentoring meetings with Dr. Irish and are supported by a team science environment including expert lab staff, postdocs, clinical fellows, and collaborators at Vanderbilt and institutions around the world. |
Keywords: human cell biology , cancer precision medicine , machine learning , cell signaling , neuroimmunology , tumor immunology Computational and Systems Biology , Stem Cell Biology & Regeneration , Immunology , Cancer Immunology , Cell Signaling , Developmental Neuroscience | |||
Tina IversonResearch in the Iverson laboratory focuses on the basis for information encoding in proteins, which may manifest as molecular recognition and cellular communication. We use a combination of structural techniques to understand these processes. Keywords: signaling , crystallography , structure , bioenergetics , recognition , electron microscopy , Structural Biology , Biophysics , Visual Sciences |
Tina | Iverson |
Research in the Iverson laboratory focuses on the basis for information encoding in proteins, which may manifest as molecular recognition and cellular communication. We use a combination of structural techniques to understand these processes. |
Keywords: signaling , crystallography , structure , bioenergetics , recognition , electron microscopy Structural Biology , Biophysics , Visual Sciences | |||
Lauren JacksonThe Jackson lab studies membrane trafficking pathways, which are the Fedex system of eukaryotic cells. We investigate structures and functions of protein complexes to understand how key proteins assemble and are regulated. We use a range of techniques, including structural biology, biochemistry, biophysics, and cell biology to understand both fundamental cellular processes and disease implications. Keywords: membrane trafficking , structural cell biology , biochemistry , biophysics , X-ray crystallography , cryoEM , Structural Biology , Biophysics , Epithelial Biology , Cell Structure |
Lauren | Jackson |
The Jackson lab studies membrane trafficking pathways, which are the Fedex system of eukaryotic cells. We investigate structures and functions of protein complexes to understand how key proteins assemble and are regulated. We use a range of techniques, including structural biology, biochemistry, biophysics, and cell biology to understand both fundamental cellular processes and disease implications. |
Keywords: membrane trafficking , structural cell biology , biochemistry , biophysics , X-ray crystallography , cryoEM Structural Biology , Biophysics , Epithelial Biology , Cell Structure | |||
David JacobsonThe Jacobson lab focus is on the mechanisms that influence pancreatic islet calcium homeostasis and hormone secretion under physiological and diabetic conditions. The goal is to identify pathways that can be therapeutically targeted to reduce pancreatic islet dysfunction and restore euglycemia in patients with diabetes. The primary models employed in these projects include: human islets, rodent islets, pancreatic slices and cultured cells. The research utilizes cutting edge approaches in molecular biology, fluorescent microscopy (both widefield and confocal), electrophysiology, biochemistry, virus mediated expression of genetically encoded indicators for calcium and membrane potential, and transgenic models. Keywords: diabetes , hormone secretion , physiology , ion channel , microscopy , neuroscience , Diabetes, Obesity, Metabolism , Cell Structure , Molecular Pathology |
David | Jacobson |
The Jacobson lab focus is on the mechanisms that influence pancreatic islet calcium homeostasis and hormone secretion under physiological and diabetic conditions. The goal is to identify pathways that can be therapeutically targeted to reduce pancreatic islet dysfunction and restore euglycemia in patients with diabetes. The primary models employed in these projects include: human islets, rodent islets, pancreatic slices and cultured cells. The research utilizes cutting edge approaches in molecular biology, fluorescent microscopy (both widefield and confocal), electrophysiology, biochemistry, virus mediated expression of genetically encoded indicators for calcium and membrane potential, and transgenic models. |
Keywords: diabetes , hormone secretion , physiology , ion channel , microscopy , neuroscience Diabetes, Obesity, Metabolism , Cell Structure , Molecular Pathology | |||
Angela JeffersonThe Vanderbilt Memory & Alzheimer’s Center is an interdisciplinary research program advancing our understanding of risk factors, early diagnostic markers, and prevention and treatment methods for memory loss and abnormal cognitive aging, including Alzheimer’s disease, cerebral small vessel disease, and neurodegeneration in older adults. Our innovative research portfolio includes initiatives (1) examining vascular health intersections with Alzheimer’s disease and neurodegeneration to identify risk factors and prevention targets, (2) identifying tools for early detection of unhealthy cognitive aging, and (3) elucidating factors underlying resilience to the clinical manifestation of Alzheimer’s disease. Trainees gain knowledge and skills working with a comprehensive, longitudinal study of older adults, including but not limited to multi-modal neuroimaging, cardiac imaging, blood and cerebrospinal fluid biomarkers, genomics and proteomics, neuropsychological assessment, and lifestyle factors. Keywords: Alzheimer's disease , cerebral small vessel disease , neurodegeneration , memory loss , clinical neuroscience , aging , Computational and Systems Biology , Imaging , Genomics , Cardiovascular Biology , Vascular Biology , Neurodegeneration and Neuroinflamation , Proteomics/Metabolomics |
Angela | Jefferson |
The Vanderbilt Memory & Alzheimer’s Center is an interdisciplinary research program advancing our understanding of risk factors, early diagnostic markers, and prevention and treatment methods for memory loss and abnormal cognitive aging, including Alzheimer’s disease, cerebral small vessel disease, and neurodegeneration in older adults. Our innovative research portfolio includes initiatives (1) examining vascular health intersections with Alzheimer’s disease and neurodegeneration to identify risk factors and prevention targets, (2) identifying tools for early detection of unhealthy cognitive aging, and (3) elucidating factors underlying resilience to the clinical manifestation of Alzheimer’s disease. Trainees gain knowledge and skills working with a comprehensive, longitudinal study of older adults, including but not limited to multi-modal neuroimaging, cardiac imaging, blood and cerebrospinal fluid biomarkers, genomics and proteomics, neuropsychological assessment, and lifestyle factors. |
Keywords: Alzheimer's disease , cerebral small vessel disease , neurodegeneration , memory loss , clinical neuroscience , aging Computational and Systems Biology , Imaging , Genomics , Cardiovascular Biology , Vascular Biology , Neurodegeneration and Neuroinflamation , Proteomics/Metabolomics | |||
Jay JeromeMy lab studies lipid and lipoprotein metabolism. We are interested in how lipids alter intracellular processes and how lipid and protein structures interact to determine lipoprotein function. These studies combine microscopy, biochemistry, molecular genetics and molecular modeling to provide robust data sets. Keywords: ABCA-1 , ApoA-1 , Cholesterol , Lipoprotein , Lysosome , Triglyceride , Diabetes, Obesity, Metabolism , Molecular Pathology , Cardiovascular Biology , Immunology |
Jay | Jerome |
My lab studies lipid and lipoprotein metabolism. We are interested in how lipids alter intracellular processes and how lipid and protein structures interact to determine lipoprotein function. These studies combine microscopy, biochemistry, molecular genetics and molecular modeling to provide robust data sets. |
Keywords: ABCA-1 , ApoA-1 , Cholesterol , Lipoprotein , Lysosome , Triglyceride Diabetes, Obesity, Metabolism , Molecular Pathology , Cardiovascular Biology , Immunology | |||
Rachelle JohnsonOur lab is interested in breast cancer dormancy and metastasis to the bone marrow. We investigate mechanisms of tumor recurrence and tumor cell entry / exit from dormancy. Our particular interest is in how cytokine signaling and hypoxia regulates these processes. Keywords: breast cancer , dormancy , metastasis , hypoxia , cytokines , bone , Cancer Biology , Cell Signaling |
Rachelle | Johnson |
Our lab is interested in breast cancer dormancy and metastasis to the bone marrow. We investigate mechanisms of tumor recurrence and tumor cell entry / exit from dormancy. Our particular interest is in how cytokine signaling and hypoxia regulates these processes. |
Keywords: breast cancer , dormancy , metastasis , hypoxia , cytokines , bone Cancer Biology , Cell Signaling | |||
Carl JohnsonOrganisms and even single cells have endogenous biological “clocks” that allow them to tell the time of day. Research in our laboratory is directed towards understanding the cellular and molecular bases of these fascinating timing mechanisms in a variety of organisms: bacteria, plants, and animals. Another major emphasis is understanding the evolution of these clocks by studying the fitness advantage conferred by these clocks, as well as experimentally evolving clocks in cells that don’t already have them! We cover many fields in this quest: biochemistry, neurobiology, biophysics, microbiology, evolutionary biology, and genetics. Keywords: Circadian Rhythms , Bioluminescence Resonance Energy Transfer (BRET) , Kai , Luciferase , Angelman Syndrome , Biological Clocks , Biophysics , Bacteriology , Cell Signaling , Developmental Neuroscience , Evolution |
Carl | Johnson |
Organisms and even single cells have endogenous biological “clocks” that allow them to tell the time of day. Research in our laboratory is directed towards understanding the cellular and molecular bases of these fascinating timing mechanisms in a variety of organisms: bacteria, plants, and animals. Another major emphasis is understanding the evolution of these clocks by studying the fitness advantage conferred by these clocks, as well as experimentally evolving clocks in cells that don’t already have them! We cover many fields in this quest: biochemistry, neurobiology, biophysics, microbiology, evolutionary biology, and genetics. |
Keywords: Circadian Rhythms , Bioluminescence Resonance Energy Transfer (BRET) , Kai , Luciferase , Angelman Syndrome , Biological Clocks Biophysics , Bacteriology , Cell Signaling , Developmental Neuroscience , Evolution | |||
Jeff JohnstonWe apply the principles and techniques of organic chemistry to create new reagents and reactions. These developments are driven by their potential to solve longstanding problems in small molecule and peptide synthesis. We collaborate with colleagues at Vanderbilt and elsewhere to advance our understanding of disease pathways using small molecule tools, ultimately aimed at early stage drug development. Keywords: organic synthesis , catalysis , total chemical synthesis , medicinal chemistry , alkaloids , peptides , Drug Design , Chemical Biology |
Jeff | Johnston |
We apply the principles and techniques of organic chemistry to create new reagents and reactions. These developments are driven by their potential to solve longstanding problems in small molecule and peptide synthesis. We collaborate with colleagues at Vanderbilt and elsewhere to advance our understanding of disease pathways using small molecule tools, ultimately aimed at early stage drug development. |
Keywords: organic synthesis , catalysis , total chemical synthesis , medicinal chemistry , alkaloids , peptides Drug Design , Chemical Biology | |||
Sebastian JoyceAdjuvant and vaccine design and mechanism/s of action Keywords: T cell function , Infection and immunity, vaccine design , MHC , Antigen processing mechanisms , Antigen presentation mechaisms , T cell development , Immunology |
Sebastian | Joyce |
Adjuvant and vaccine design and mechanism/s of action |
Keywords: T cell function , Infection and immunity, vaccine design , MHC , Antigen processing mechanisms , Antigen presentation mechaisms , T cell development Immunology | |||
Katty KangThe Kang Laboratory is interested in understanding the role of GABAergic signaling in disease conditions as well as in normal brain development. Currently, lab staff members are investigating the molecular pathophysiology of genetic variations/mutations in GABAA receptor subunits and GABA transporter 1, two major components of GABAergic signaling and common pediatric disorders: epilepsy, autism and intellectual disability. The goal is to understand how a single nucleotide change like a mutation could define the whole life of a child and identify the most effective precision treatments for those who have these disorders in order to improve their life outcome. Keywords: GABAergic signaling , Epilepsy , autism , intellectual disability , precision treatment , brain development , Molecular Pathology , Cell Signaling , Developmental Neuroscience |
Katty | Kang |
The Kang Laboratory is interested in understanding the role of GABAergic signaling in disease conditions as well as in normal brain development. Currently, lab staff members are investigating the molecular pathophysiology of genetic variations/mutations in GABAA receptor subunits and GABA transporter 1, two major components of GABAergic signaling and common pediatric disorders: epilepsy, autism and intellectual disability. The goal is to understand how a single nucleotide change like a mutation could define the whole life of a child and identify the most effective precision treatments for those who have these disorders in order to improve their life outcome. |
Keywords: GABAergic signaling , Epilepsy , autism , intellectual disability , precision treatment , brain development Molecular Pathology , Cell Signaling , Developmental Neuroscience | |||
Erkan KarakasMy laboratory is interested in understanding the molecular mechanism of calcium signaling at the ER-mitochondria contact sites. Our goal is to uncover the molecular mechanisms underlying the activity and regulation of key protein complexes involved in calcium signaling at the ER-mitochondria contact sites using innovative structural biological methods including X-ray crystallography and cryo-electron microscopy (cryo-EM) together with biophysical, biochemical and functional methods. Keywords: Structural biology , X-ray Crystallography , cryo-EM , Calcium signaling , ion channel , mitochondria , Structural Biology , Biophysics , Cell Signaling |
Erkan | Karakas |
My laboratory is interested in understanding the molecular mechanism of calcium signaling at the ER-mitochondria contact sites. Our goal is to uncover the molecular mechanisms underlying the activity and regulation of key protein complexes involved in calcium signaling at the ER-mitochondria contact sites using innovative structural biological methods including X-ray crystallography and cryo-electron microscopy (cryo-EM) together with biophysical, biochemical and functional methods. |
Keywords: Structural biology , X-ray Crystallography , cryo-EM , Calcium signaling , ion channel , mitochondria Structural Biology , Biophysics , Cell Signaling | |||
John KarijolichThe long term goal of our laboratory is to uncover fundamental mechanisms of gene expression by exploiting the interactions of viruses with their host. Keywords: RNA , Virus , Gene expression , Innate immunity , Host-Pathogen Interactions , RNA Biology , Gene Regulation , Virology |
John | Karijolich |
The long term goal of our laboratory is to uncover fundamental mechanisms of gene expression by exploiting the interactions of viruses with their host. |
Keywords: RNA , Virus , Gene expression , Innate immunity Host-Pathogen Interactions , RNA Biology , Gene Regulation , Virology | |||
Ege KavalaliOur group studies mechanisms underlying presynaptic function and its impact on neuronal signaling. Keywords: synaptic vesicle recycling , neurotransmitter release , Calcium signaling , synapse assembly and nanostructure , synaptic plasticity , rapid antidepressant action , Cell Signaling , Synaptic Function and Neuroendocrinology |
Ege | Kavalali |
Our group studies mechanisms underlying presynaptic function and its impact on neuronal signaling. |
Keywords: synaptic vesicle recycling , neurotransmitter release , Calcium signaling , synapse assembly and nanostructure , synaptic plasticity , rapid antidepressant action Cell Signaling , Synaptic Function and Neuroendocrinology | |||
Irina KaverinaMicrotubules are dynamic biopolymers, which serve as major trafficking highways in cells. Microtubule-dependent transport is critical for physiology of all cell types, and disturbance of microtubule networks underlies many human diseases, from neurodegeneration to diabetes. Kaverina laboratory uses high-end microscopy combined with molecular and computational approaches to target basic cell biology of microtubules as well as the role of microtubules in pancreatic beta cell physiology and diabetes. Keywords: microtubules , Golgi , cell migration , insulin secretion , diabetes , microscopy , cytoskeleton , Diabetes, Obesity, Metabolism , Imaging , Cell Structure , Cell Signaling , Computational and Systems Biology , Developmental Biology |
Irina | Kaverina |
Microtubules are dynamic biopolymers, which serve as major trafficking highways in cells. Microtubule-dependent transport is critical for physiology of all cell types, and disturbance of microtubule networks underlies many human diseases, from neurodegeneration to diabetes. Kaverina laboratory uses high-end microscopy combined with molecular and computational approaches to target basic cell biology of microtubules as well as the role of microtubules in pancreatic beta cell physiology and diabetes. |
Keywords: microtubules , Golgi , cell migration , insulin secretion , diabetes , microscopy , cytoskeleton Diabetes, Obesity, Metabolism , Imaging , Cell Structure , Cell Signaling , Computational and Systems Biology , Developmental Biology | |||
Tae Kon (TK) KimThe Kim lab (KIM LAB AT VUMC-HEM/ONC) is in the division of Hematology/Oncology, the department of Medicine at Vanderbilt University Medical Center. The Kim lab is also affiliated with Vanderbilt Center for Immunobiology (VCI) and Vanderbilt Institute for Infection, Immunology and Inflammation (VI4). Dr. Kim (PI) is a physician who treats leukemia/lymphoma/myeloma patients using chemotherapy and stem cell transplantation. Dr. Kim is also an immunologist who is interested in tumor (Cancer) immunology, checkpoint immunology (beyond PD-1 and PD-L1) and transplant immunology. We are looking for enthusiastic students and post-doctoral fellows. Keywords: Cancer Immunology , Checkpoint biology , Graft-versus-host disease , VISTA , PD-1-PD-L1 , LAIR1 , Cancer Biology , Cancer Immunology , Immunology , |
Tae Kon (TK) | Kim |
The Kim lab (KIM LAB AT VUMC-HEM/ONC) is in the division of Hematology/Oncology, the department of Medicine at Vanderbilt University Medical Center. The Kim lab is also affiliated with Vanderbilt Center for Immunobiology (VCI) and Vanderbilt Institute for Infection, Immunology and Inflammation (VI4). Dr. Kim (PI) is a physician who treats leukemia/lymphoma/myeloma patients using chemotherapy and stem cell transplantation. Dr. Kim is also an immunologist who is interested in tumor (Cancer) immunology, checkpoint immunology (beyond PD-1 and PD-L1) and transplant immunology. We are looking for enthusiastic students and post-doctoral fellows. |
Keywords: Cancer Immunology , Checkpoint biology , Graft-versus-host disease , VISTA , PD-1-PD-L1 , LAIR1 Cancer Biology , Cancer Immunology , Immunology , | |||
Annet KiraboResearch in my laboratory focuses on understanding the interaction between oxidative stress and inflammation in the genesis of cardiovascular disease. We are studying the role of excess dietary salt in inducing activation of the innate immune system leading to hypertension via formation of the fatty acid oxidation products known as isolevuglandins. We are also studying the impact of excess dietary salt on the gut microbiome. Keywords: Cardiovascular disease , Hypertension , Inflammation , fatty acid oxidation , isolevuglandins , Immunity , Diabetes, Obesity, Metabolism , Immunology , Cardiovascular Biology |
Annet | Kirabo |
Research in my laboratory focuses on understanding the interaction between oxidative stress and inflammation in the genesis of cardiovascular disease. We are studying the role of excess dietary salt in inducing activation of the innate immune system leading to hypertension via formation of the fatty acid oxidation products known as isolevuglandins. We are also studying the impact of excess dietary salt on the gut microbiome. |
Keywords: Cardiovascular disease , Hypertension , Inflammation , fatty acid oxidation , isolevuglandins , Immunity Diabetes, Obesity, Metabolism , Immunology , Cardiovascular Biology | |||
Austin KirschnerAs a cancer biologist and radiation oncologist, we study new approaches for combining X-ray radiation treatment and other treatments, such as chemotherapy, targeted drug therapy, and immunotherapy. We are investigating the interactions and mechanisms for improved therapeutic effects of combination treatments involving X-ray radiation therapy. Our research work, models, and projects are geared toward translation to the clinical setting. We leverage combination approaches to provide enhanced cancer treatment and understand the biological pathways involved. Keywords: Radiation treatment , Combination treatment , Cancer biology pathways , Immunotherapy , Targeted drug therapy , Chemotherapy , Drug Design , Cancer Biology , Cancer Immunology |
Austin | Kirschner |
As a cancer biologist and radiation oncologist, we study new approaches for combining X-ray radiation treatment and other treatments, such as chemotherapy, targeted drug therapy, and immunotherapy. We are investigating the interactions and mechanisms for improved therapeutic effects of combination treatments involving X-ray radiation therapy. Our research work, models, and projects are geared toward translation to the clinical setting. We leverage combination approaches to provide enhanced cancer treatment and understand the biological pathways involved. |
Keywords: Radiation treatment , Combination treatment , Cancer biology pathways , Immunotherapy , Targeted drug therapy , Chemotherapy Drug Design , Cancer Biology , Cancer Immunology | |||
Brett KronckeWe want to be able to accurately predict the phenotype of any and all genetic variants. Our approach is to collect as much phenotype information–at high and low resolution–as is feasible for the largest number of variants and then leverage experimental and computational structural biology to fill in the details for yet uncharacterized variants. To develop this methodology, we are starting with ion channels involved in the heart contraction cycle. Keywords: |
Brett | Kroncke |
We want to be able to accurately predict the phenotype of any and all genetic variants. Our approach is to collect as much phenotype information–at high and low resolution–as is feasible for the largest number of variants and then leverage experimental and computational structural biology to fill in the details for yet uncharacterized variants. To develop this methodology, we are starting with ion channels involved in the heart contraction cycle. |
Keywords: | |||
Rachel Kuchtey– Our discovery of ADAMTS10 causing open angle glaucoma in dogs led us to form the microfibril hypothesis of glaucoma. – We use a variety of animal models, including mice, pigs and zebrafish to investigate the mechanisms of glaucomatous optic neuropathy. – We use state-of-art imaging and electrophysiology technology, such as optical coherence tomography, electroretinogram, atomic force microscopy, electron microscopy, confocal microscopy and polarized light microscopy to study mechanisms of optic nerve damage at the cellular and tissue levels. Keywords: glaucoma , microfibril , animal models , retinal ganglion cells , intraocular pressure , extracellular matrix , Imaging , Visual Sciences , Developmental Neuroscience |
Rachel | Kuchtey |
– Our discovery of ADAMTS10 causing open angle glaucoma in dogs led us to form the microfibril hypothesis of glaucoma. – We use a variety of animal models, including mice, pigs and zebrafish to investigate the mechanisms of glaucomatous optic neuropathy. – We use state-of-art imaging and electrophysiology technology, such as optical coherence tomography, electroretinogram, atomic force microscopy, electron microscopy, confocal microscopy and polarized light microscopy to study mechanisms of optic nerve damage at the cellular and tissue levels. |
Keywords: glaucoma , microfibril , animal models , retinal ganglion cells , intraocular pressure , extracellular matrix Imaging , Visual Sciences , Developmental Neuroscience | |||
Borden LacyPathogenic bacteria have evolved a diverse array of mechanisms for delivering toxins and other virulence factors into the interior of host cells. Studying the molecular structures of these virulence factors alone and in complex with host receptors, membranes, and inhibitors can lend insight into how these delivery processes occur and how these processes can be exploited or prevented. Current research in the Lacy laboratory is primarily focused on the structure and function of large clostridial cytotoxins, including the two toxins responsible for symptoms in Clostridium difficile infection. Structural biology is combined with cellular, tissue, and animal models of intoxication and infection to understand the toxin-host interaction at the molecular level. In addition, we aim to identify new toxin inhibitors using both rational design and high-throughput screening approaches. Keywords: Clostridium difficile , bacterial pathogenesis , toxins , structural biology , electron microscopy , crystallography , Structural Biology , Drug Design , Host-Pathogen Interactions , Epithelial Biology , Bacteriology , Molecular Pathology |
Borden | Lacy |
Pathogenic bacteria have evolved a diverse array of mechanisms for delivering toxins and other virulence factors into the interior of host cells. Studying the molecular structures of these virulence factors alone and in complex with host receptors, membranes, and inhibitors can lend insight into how these delivery processes occur and how these processes can be exploited or prevented. Current research in the Lacy laboratory is primarily focused on the structure and function of large clostridial cytotoxins, including the two toxins responsible for symptoms in Clostridium difficile infection. Structural biology is combined with cellular, tissue, and animal models of intoxication and infection to understand the toxin-host interaction at the molecular level. In addition, we aim to identify new toxin inhibitors using both rational design and high-throughput screening approaches. |
Keywords: Clostridium difficile , bacterial pathogenesis , toxins , structural biology , electron microscopy , crystallography Structural Biology , Drug Design , Host-Pathogen Interactions , Epithelial Biology , Bacteriology , Molecular Pathology | |||
Bennett LandmanThe MASI research laboratory concentrates on analyzing large-scale cross-sectional and longitudinal neuroimaging data. Specifically, we are interested in population characterization with magnetic resonance imaging (MRI), multi-parametric studies (DTI, sMRI, qMRI), and shape modeling. Keywords: medical image processing , magnetic resonance imaging , computed tomography , Computational and Systems Biology , Imaging , Neurodegeneration and Neuroinflamation |
Bennett | Landman |
The MASI research laboratory concentrates on analyzing large-scale cross-sectional and longitudinal neuroimaging data. Specifically, we are interested in population characterization with magnetic resonance imaging (MRI), multi-parametric studies (DTI, sMRI, qMRI), and shape modeling. |
Keywords: medical image processing , magnetic resonance imaging , computed tomography Computational and Systems Biology , Imaging , Neurodegeneration and Neuroinflamation | |||
Deborah LanniganWe are interested in understanding how signal transduction pathways maintain function during homeostasis and how these processes are disrupted in various disease etiologies, which include breast cancer, infection and chemotherapy-induced cardiac toxicity. To study these questions we employ a variety of techniques, which include modern molecular biology and biochemistry, enzyme kinetics, novel assay development, high throughput screening, drug development, quantitative microscopy, various animal models, novel patient-derived explant cultures, patient-derived xenografts and bioinformatics. Keywords: Drug Development , Breast Cancer , Mammary Gland Development , Intracellular Pathogens , Chemotherapy-Induced Cardiac Toxicity , Gene Regulation , Drug Design , Gene Regulation , Immunology , Cancer Biology , Cancer Immunology , Cell Signaling |
Deborah | Lannigan |
We are interested in understanding how signal transduction pathways maintain function during homeostasis and how these processes are disrupted in various disease etiologies, which include breast cancer, infection and chemotherapy-induced cardiac toxicity. To study these questions we employ a variety of techniques, which include modern molecular biology and biochemistry, enzyme kinetics, novel assay development, high throughput screening, drug development, quantitative microscopy, various animal models, novel patient-derived explant cultures, patient-derived xenografts and bioinformatics. |
Keywords: Drug Development , Breast Cancer , Mammary Gland Development , Intracellular Pathogens , Chemotherapy-Induced Cardiac Toxicity , Gene Regulation Drug Design , Gene Regulation , Immunology , Cancer Biology , Cancer Immunology , Cell Signaling | |||
Ken LauThe Lau lab considers every one of the 30 plus trillion cells in the body to be unique, thus, utilizes state-of-the art technologies to profile tissues at the single-cell resolution. Resulting “big data” consisting of thousands of data points and dimensions are analyzed by data science-driven computational techniques. Keywords: single-cell biology , algorithms , data science , colon cancer , stem cells , transcriptomics , Computational and Systems Biology , Stem Cell Biology & Regeneration , Epithelial Biology , Gene Regulation , Genomics , Molecular Pathology , Neurodegeneration and Neuroinflamation , Developmental Neuroscience , Developmental Biology |
Ken | Lau |
The Lau lab considers every one of the 30 plus trillion cells in the body to be unique, thus, utilizes state-of-the art technologies to profile tissues at the single-cell resolution. Resulting “big data” consisting of thousands of data points and dimensions are analyzed by data science-driven computational techniques. |
Keywords: single-cell biology , algorithms , data science , colon cancer , stem cells , transcriptomics Computational and Systems Biology , Stem Cell Biology & Regeneration , Epithelial Biology , Gene Regulation , Genomics , Molecular Pathology , Neurodegeneration and Neuroinflamation , Developmental Neuroscience , Developmental Biology | |||
Amanda LeaResearch in the Lea lab sits at the intersection of evolutionary biology, genomics, and human health research. Much of our work focuses on two questions: (i) what are the molecular mechanisms that connect environmental challenges (e.g., social or nutritional stress) experienced across the life course with compromised health? and (ii) why do health outcomes vary among individuals exposed to the same environmental challenge? Our primary study systems are small-scale, subsistence-level populations that are currently transitioning to more urban and market-integrated lifestyles. We focus on subsistence-level populations because they experience socioecological variation representative of human evolutionary history, and because they provide opportunities to investigate how major, ongoing environmental shifts-namely urbanization and market-integration-impact health. Keywords: evolutionary biology , evolutionary medicine , human genomics , human epigenomics , biological anthropology , , Diabetes, Obesity, Metabolism , Gene Regulation , Genomics |
Amanda | Lea |
Research in the Lea lab sits at the intersection of evolutionary biology, genomics, and human health research. Much of our work focuses on two questions: (i) what are the molecular mechanisms that connect environmental challenges (e.g., social or nutritional stress) experienced across the life course with compromised health? and (ii) why do health outcomes vary among individuals exposed to the same environmental challenge? Our primary study systems are small-scale, subsistence-level populations that are currently transitioning to more urban and market-integrated lifestyles. We focus on subsistence-level populations because they experience socioecological variation representative of human evolutionary history, and because they provide opportunities to investigate how major, ongoing environmental shifts-namely urbanization and market-integration-impact health. |
Keywords: evolutionary biology , evolutionary medicine , human genomics , human epigenomics , biological anthropology , Diabetes, Obesity, Metabolism , Gene Regulation , Genomics | |||
Ethan LeeOur lab is interested in the basic mechanism of Wnt signal transduction, a pathway that plays critical roles in the early development of multicellular organisms and the maintenance of intestinal stem cells in adults. Misregulated Wnt signaling is often implicated in human diseases such as colorectal cancer. We use biochemistry, chemical biology, cell biology, and developmental biology to study the Wnt pathway. Keywords: Wnt pathway , Signal transduction , Cancer , Stem cells , Biochemistry , Cell biology , Regenerative medicine , Stem Cell Biology & Regeneration , Cancer Biology , Cell Signaling , Developmental Biology , Chemical Biology |
Ethan | Lee |
Our lab is interested in the basic mechanism of Wnt signal transduction, a pathway that plays critical roles in the early development of multicellular organisms and the maintenance of intestinal stem cells in adults. Misregulated Wnt signaling is often implicated in human diseases such as colorectal cancer. We use biochemistry, chemical biology, cell biology, and developmental biology to study the Wnt pathway. |
Keywords: Wnt pathway , Signal transduction , Cancer , Stem cells , Biochemistry , Cell biology , Regenerative medicine Stem Cell Biology & Regeneration , Cancer Biology , Cell Signaling , Developmental Biology , Chemical Biology | |||
Ed LevineWe study the developmental biology of the mammalian retina, from the initial patterning events through the formation of the multiple retinal cell types. We also study retinal regeneration as a way to repair damaged tissue resulting from injury or disease. Keywords: mouse genetics , tissue growth , cell proliferation , cell differentiation , developmental timing , regeneration , Stem Cell Biology & Regeneration , Visual Sciences , Developmental Neuroscience , Developmental Biology |
Ed | Levine |
We study the developmental biology of the mammalian retina, from the initial patterning events through the formation of the multiple retinal cell types. We also study retinal regeneration as a way to repair damaged tissue resulting from injury or disease. |
Keywords: mouse genetics , tissue growth , cell proliferation , cell differentiation , developmental timing , regeneration Stem Cell Biology & Regeneration , Visual Sciences , Developmental Neuroscience , Developmental Biology | |||
Alan LewisOur research focuses on understanding the neurobiology underlying cognitive and social impairments in neuropsychiatric disorders. We are particularly interested in neurodevelopmental disorders such as schizophrenia and autism and their effects on hippocampal function. Our goal is to use a “bedside to bench” approach, starting with robust, replicable findings in human patient populations and applying cutting edge neuroscience techniques in rodent models to understand underlying pathophysiology. Keywords: |
Alan | Lewis |
Our research focuses on understanding the neurobiology underlying cognitive and social impairments in neuropsychiatric disorders. We are particularly interested in neurodevelopmental disorders such as schizophrenia and autism and their effects on hippocampal function. Our goal is to use a “bedside to bench” approach, starting with robust, replicable findings in human patient populations and applying cutting edge neuroscience techniques in rodent models to understand underlying pathophysiology. |
Keywords: | |||
Bingshan LiMy resource is focused on developing statistical models and computational tool to understand genetic basis of human complex disease, with a particular focus on neuropsychiatric disorders. We integrate multifaceted functional genomics data (DNA, RNA, epigenomics) data to dissect the mechanisms of genes implicated in complex diseases on a genome-wide scale. Keywords: Genetics of complex disease , Functional genomics , Computational modeling , Psychiatric disorders , Integrative genomics , Computational and Systems Biology , Gene Regulation , Genomics , Neurodegeneration and Neuroinflamation , Developmental Neuroscience , Synaptic Function and Neuroendocrinology , Proteomics/Metabolomics |
Bingshan | Li |
My resource is focused on developing statistical models and computational tool to understand genetic basis of human complex disease, with a particular focus on neuropsychiatric disorders. We integrate multifaceted functional genomics data (DNA, RNA, epigenomics) data to dissect the mechanisms of genes implicated in complex diseases on a genome-wide scale. |
Keywords: Genetics of complex disease , Functional genomics , Computational modeling , Psychiatric disorders , Integrative genomics Computational and Systems Biology , Gene Regulation , Genomics , Neurodegeneration and Neuroinflamation , Developmental Neuroscience , Synaptic Function and Neuroendocrinology , Proteomics/Metabolomics | |||
Andrew LinkMy diverse laboratory develops and applies advanced technologies and approaches to identify novel and unexpected genes and proteins involved in the fundamental process of protein translation and immune responses. Selected genes are functionally and mechanistically pursued using a diverse array of experimental approaches and model organisms. Keywords: protein translation , immune response , proteomics , functional genomics , Genomics , Immunology , Proteomics/Metabolomics |
Andrew | Link |
My diverse laboratory develops and applies advanced technologies and approaches to identify novel and unexpected genes and proteins involved in the fundamental process of protein translation and immune responses. Selected genes are functionally and mechanistically pursued using a diverse array of experimental approaches and model organisms. |
Keywords: protein translation , immune response , proteomics , functional genomics Genomics , Immunology , Proteomics/Metabolomics | |||
MacRae LintonThe Linton laboratory pursues basic science and clinical translational investigations of inherited disorders of lipoprotein metabolism, macrophage biology, and atherosclerosis. Dr. Linton pioneered the use of bone marrow transplantation (BMT) as an approach to investigate the impact of genes expressed by bone marrow-derived cells, including macrophages, on the development of atherosclerosis in murine models. A major area of interest is the role of HDL function in human disease. We also are actively involved in clinical cardiovascular outcome trials of lipid lowering drugs, including a recent gene therapy study in familial hypercholesterolemia. Keywords: Atherosclerosis , Lipoprotein metabolism , Macrophages , HDL , genetics of lipoprotein disorders , gene therapy , Diabetes, Obesity, Metabolism , Cardiovascular Biology , Vascular Biology |
MacRae | Linton |
The Linton laboratory pursues basic science and clinical translational investigations of inherited disorders of lipoprotein metabolism, macrophage biology, and atherosclerosis. Dr. Linton pioneered the use of bone marrow transplantation (BMT) as an approach to investigate the impact of genes expressed by bone marrow-derived cells, including macrophages, on the development of atherosclerosis in murine models. A major area of interest is the role of HDL function in human disease. We also are actively involved in clinical cardiovascular outcome trials of lipid lowering drugs, including a recent gene therapy study in familial hypercholesterolemia. |
Keywords: Atherosclerosis , Lipoprotein metabolism , Macrophages , HDL , genetics of lipoprotein disorders , gene therapy Diabetes, Obesity, Metabolism , Cardiovascular Biology , Vascular Biology | |||
Ethan LippmannOur lab seeks to model, understand, and treat neurodegenerative disease, with a particular focus on neurovascular function and crosstalk. We operate at the intersection of engineering and regenerative medicine, and our projects span a wide variety of disciplines. We employ a number of techniques to carry out our work, including human induced pluripotent stem cell differentiation, genetic engineering, biomaterial and microdevice fabrication, high throughput screening, and molecular selection. Keywords: human induced pluripotent stem cells , blood-brain barrier , neurovascular , neurodegenerative disease , engineering , CRISPR , Stem Cell Biology & Regeneration , Vascular Biology , Neurodegeneration and Neuroinflamation |
Ethan | Lippmann |
Our lab seeks to model, understand, and treat neurodegenerative disease, with a particular focus on neurovascular function and crosstalk. We operate at the intersection of engineering and regenerative medicine, and our projects span a wide variety of disciplines. We employ a number of techniques to carry out our work, including human induced pluripotent stem cell differentiation, genetic engineering, biomaterial and microdevice fabrication, high throughput screening, and molecular selection. |
Keywords: human induced pluripotent stem cells , blood-brain barrier , neurovascular , neurodegenerative disease , engineering , CRISPR Stem Cell Biology & Regeneration , Vascular Biology , Neurodegeneration and Neuroinflamation | |||
Carlos LopezStructure of biological regulatory networks, dynamics, and noise. Method development, parameter estimation, machine learning, data science, AI, and simulations across scales. Keywords: systems biology , methods development , network dynamics , gene regulation , signaling , calibration , Computational and Systems Biology , Gene Regulation , Cancer Biology |
Carlos | Lopez |
Structure of biological regulatory networks, dynamics, and noise. Method development, parameter estimation, machine learning, data science, AI, and simulations across scales. |
Keywords: systems biology , methods development , network dynamics , gene regulation , signaling , calibration Computational and Systems Biology , Gene Regulation , Cancer Biology | |||
Christine LovlyResearch in the Lovly lab focuses on two major themes: 1) stratification of lung tumors into clinically relevant molecular subsets, with a particular interest in those tumors which harbor EGFR mutations, ALK gene rearrangements, and small cell lung cancer and 2) determination of the molecular mechanisms leading to primary and acquired resistance to anti-cancer therapies. We work from the ground up to understand the key genetic and molecular events contributing to the development and progression of lung cancer, utilizing a variety of techniques, including genomic and proteomic studies, in silico modeling, and high throughput / high content imaging screens in order to obtain deep mechanistic insights into these events. Our entire team is excited to welcome new members and share our passion for translational lung cancer research! Keywords: Translational cancer research , Lung Cancer , Drug resistance , Genomics , Clinical trials , Genomics , Proteomics/Metabolomics |
Christine | Lovly |
Research in the Lovly lab focuses on two major themes: 1) stratification of lung tumors into clinically relevant molecular subsets, with a particular interest in those tumors which harbor EGFR mutations, ALK gene rearrangements, and small cell lung cancer and 2) determination of the molecular mechanisms leading to primary and acquired resistance to anti-cancer therapies. We work from the ground up to understand the key genetic and molecular events contributing to the development and progression of lung cancer, utilizing a variety of techniques, including genomic and proteomic studies, in silico modeling, and high throughput / high content imaging screens in order to obtain deep mechanistic insights into these events. Our entire team is excited to welcome new members and share our passion for translational lung cancer research! |
Keywords: Translational cancer research , Lung Cancer , Drug resistance , Genomics , Clinical trials Genomics , Proteomics/Metabolomics | |||
Terry LybrandIn our laboratory, we utilize computational methods to study the properties and behavior of biomacromolecules and ligand-biomacromolecule complexes, and to aid in the design of small molecule ligands with desired binding properties for targeted receptors. Techniques used include quantum mechanical calculations, molecular dynamics and Monte Carlo simulation, and free energy perturbation methods. Computational methods complement experimental techniques and can enhance our understanding of biomacromolecular function. Keywords: Quantum mechanics , Statistical mechanics , molecular dynamics , QM/MM , protein structure-dynamics-function relationships , Structural Biology , Biophysics , Drug Design , Computational and Systems Biology |
Terry | Lybrand |
In our laboratory, we utilize computational methods to study the properties and behavior of biomacromolecules and ligand-biomacromolecule complexes, and to aid in the design of small molecule ligands with desired binding properties for targeted receptors. Techniques used include quantum mechanical calculations, molecular dynamics and Monte Carlo simulation, and free energy perturbation methods. Computational methods complement experimental techniques and can enhance our understanding of biomacromolecular function. |
Keywords: Quantum mechanics , Statistical mechanics , molecular dynamics , QM/MM , protein structure-dynamics-function relationships Structural Biology , Biophysics , Drug Design , Computational and Systems Biology | |||
Ian MacaraWe use a wide range of cutting-edge technologies, from single-molecule imaging to mouse models, to investigate how epithelial cells polarize and organize into tissues, and how these processes are disrupted in cancer. We use the mammary gland as a model, and study the role of stem cells and progenitors in responses to tissue damage, and mechanisms of homeostasis. Keywords: stem cells , cell imaging , polarity , breast cancer , epithelia , CRISPR , Imaging , Stem Cell Biology & Regeneration , Epithelial Biology , Cancer Biology , Developmental Biology |
Ian | Macara |
We use a wide range of cutting-edge technologies, from single-molecule imaging to mouse models, to investigate how epithelial cells polarize and organize into tissues, and how these processes are disrupted in cancer. We use the mammary gland as a model, and study the role of stem cells and progenitors in responses to tissue damage, and mechanisms of homeostasis. |
Keywords: stem cells , cell imaging , polarity , breast cancer , epithelia , CRISPR Imaging , Stem Cell Biology & Regeneration , Epithelial Biology , Cancer Biology , Developmental Biology | |||
Jason MacGurnWe are broadly interested in understanding how eukaryotic cells regulate membrane trafficking and protein degradation decisions and how these pathways are dysregulated in disease states. We investigate these regulatory pathways using biochemistry, proteomics, and live cell imaging in yeast and mammalian cells with the long-term goal of harnessing the intrinsic protein degradation machinery of eukaryotic cells as a therapeutic strategy for treatment of disease. Keywords: membrane trafficking , cell signaling , ubiquitin biology , Imaging , Epithelial Biology , Cancer Biology , Cell Signaling , Developmental Biology , Proteomics/Metabolomics |
Jason | MacGurn |
We are broadly interested in understanding how eukaryotic cells regulate membrane trafficking and protein degradation decisions and how these pathways are dysregulated in disease states. We investigate these regulatory pathways using biochemistry, proteomics, and live cell imaging in yeast and mammalian cells with the long-term goal of harnessing the intrinsic protein degradation machinery of eukaryotic cells as a therapeutic strategy for treatment of disease. |
Keywords: membrane trafficking , cell signaling , ubiquitin biology Imaging , Epithelial Biology , Cancer Biology , Cell Signaling , Developmental Biology , Proteomics/Metabolomics | |||
Meena MadhurThe Madhur lab seeks to elucidate inflammatory mechanisms in hypertension and vascular disease. There is growing evidence that cardiometabolic diseases have an inflammatory basis. We use cell culture, mouse models, bioinformatics, mass cytometry, flow cytometry, and human blood and tissues to investigate inflammatory pathways and identify novel therapeutic targets. Keywords: cardiovascular , hypertension , vascular , inflammation , immunity , cytokines , Immunology , Cardiovascular Biology , Cell Signaling , Vascular Biology |
Meena | Madhur |
The Madhur lab seeks to elucidate inflammatory mechanisms in hypertension and vascular disease. There is growing evidence that cardiometabolic diseases have an inflammatory basis. We use cell culture, mouse models, bioinformatics, mass cytometry, flow cytometry, and human blood and tissues to investigate inflammatory pathways and identify novel therapeutic targets. |
Keywords: cardiovascular , hypertension , vascular , inflammation , immunity , cytokines Immunology , Cardiovascular Biology , Cell Signaling , Vascular Biology | |||
Mark MagnusonThe Magnuson Laboratory uses genetically-altered mice, next generation sequencing, and bioinformatics to study the gene regulatory network (GRN) that underpins pancreatic endocrine cell identity and function. Our current studies are focused on analyzing the effects of a chronic elevation in intracellular Ca2+ (excitotoxicity) on the GRN in mature beta-cells, and the role of several zinc finger transcription factors in these networks. In addition, we are interested in determining how Sox17 gene expression is controlled during early development, and are using CRISPR mutagenesis and embryonic stem cells to identify the key transcriptional factors that regulate formation of both the definitive endoderm and vascular endothelial cells. Keywords: Stem cells , CRISPR , Zinc finger proteins , Gene networks , Bioinformatics , Diabetes |