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Zach M. Sandusky

Graduate Student, Lannigan Lab


Research Description:

My project is focused on signaling pathways that are involved in normal mammary gland development and breast cancer with the overall goal of identifying novel therapeutic targets. To achieve this goal, I utilize a combination of in vitro techniques, mouse models, and clinical samples.

 

Publications:

Li M., Li Y., Ludwik K.A., Sandusky Z.M., Lannigan D.A., and O'Doherty G.A. Stereoselective Synthesis and Evaluation of C6′′-Substituted 5a-Carbasugar Analogues of SL0101 as Inhibitors of RSK1/2. Org Lett. 19(9):2410-2413. 2017

Ludwik K.A., Campbell J.P., Li M., Li Y., Sandusky Z.M., Pasic L., Sowder M.E., Brenin D.R., Pietenpol J.A., O'Doherty G.A., and Lannigan D.A. Development of a RSK Inhibitor as a Novel Therapy for Triple-Negative Breast Cancer. Mol Cancer Ther. 15(11):2598-2608. 2016

Li M., Mrozowski R.M., Sandusky Z.M., Shan M., Song, X., Wu B., Zhang Q., Lannigan D.A., and O’Doherty G.A. Synthesis and Structure-Activity Relationship Study of 5a-Carbasugar Analogues of SL0101. ACS Med Chem Lett. 6(1):95-9. 2014

Mrozowski R.M., Sandusky Z.M., Vemula R., Wu B., Zhang Q., Lannigan D.A., and O’Doherty G.A. De novo synthesis and biological evaluation of C6”-substituted C4”-amide analogues of SL0101. Org Lett. 16(22)5996-9. 2014