2026
Radiation-induced autophagy regulates fibroblast mitochondrial metabolism and crosstalk with triple-negative breast cancer cells
Rafat Lab | March 24, 2026
TBCRC 035: randomized phase II pharmacodynamic study of standard and reduced-dose palbociclib with endocrine therapy in hormone receptor (HR)-positive previously treated metastatic breast cancer
Park Lab | March 10, 2026
The Pathologic Response Evaluation and Detection in Circulating Tumor-DNA Study: Ultrasensitive Circulating Tumor-DNA Assessment of Breast Cancer Minimal Residual Disease
Park Lab | March 10, 2026
Evaluation of Pafolacianine (Cytalux®) for Fluorescence-Guided Surgery in Head and Neck Squamous Cell Carcinoma: A Negative Study with Important Clinical Implications
Rosenthal Lab | February 28, 2026
EGFRvIII expression in head and neck squamous cell carcinoma: clinical significance and sources of frequency variation across studies
Rosenthal Lab | February 25, 2026
Abaloparatide and paclitaxel combination therapy Improves bone volume and tumor burden in Bone-Metastatic breast cancer
Johnson & Rhoades Labs | February 20, 2026
Regulation of tumor proliferation by unlocking silent synapses on metastatic cancer cells
Fingleton Lab | February 18, 2026
Historical Perspective of HER2 Testing and Treatment in Prostate Cancer
Hurley Lab | February 2, 2026
Digital spatial profiling of α-PD-1 treated breast cancer bone metastases reveals region-specific signaling and enrichment of immune-suppressive markers
Johnson Lab | January 29, 2026
Glutamine synthetase deficiency enhances CD8 T cell survival and stress resilience in the tumor microenvironment
J. Wilson Lab | January 21, 2026
TCF1lo CD8 T cells proliferate and persist autonomously in tumors
Philip Lab | January 21, 2026
Use of Dual-Modality Antibody Imaging for Assessment of Lymph Node Metastases in Head and Neck Cancer
Rosenthal Lab | January 14, 2026
RAS/MEK/PI3K pathway inhibition augments response to CD40 agonism by targeting CD11b+ Bregs thereby overcoming melanoma PD1-resistance
Weiss Lab | January 12, 2026
An integrated single-cell and spatial transcriptomic atlas of thyroid cancer progression identifies prognostic fibroblast subpopulations
E. Lee & Weiss Labs | January 9, 2026
Clonal Hematopoiesis and Cardiovascular Disease Risk After Cancer Therapy in Patients With Solid Tumors
Park Lab | January 8, 2026
2025
TMPRSS11B promotes an acidified microenvironment and immune suppression in squamous lung cancer
Hwang Lab | December 26, 2025
Proteomic Analysis of PTEN-Deficient Cells Reveals Src-Mediated Upregulation of EphA2 and Therapeutic Potential of Dual Inhibition
Park Lab | December 24, 2025
Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia
DelGiorno Lab | December 23, 2025
Epithelial WNT secretion drives niche escape of developing gastric cancer
Goldenring Lab | December 16, 2025
The Impact of JAK1 Pathogenic Variants and MHC-I Expression on Response to Immune Checkpoint Inhibition in Endometrial Cancer
Balko Lab | December 15, 2025
Monitoring systemic immune responses to checkpoint inhibition in breast cancer reveals host responses and mechanisms of resistance
Balko Lab | December 10, 2025
CD8+ T cells in the tumor microenvironment modulate the response to endocrine therapy in breast cancer
Balko Lab | December 9, 2025
Reprogramming the Course of Precancer with Targeted Therapeutic Intervention: Lessons from Interception in Gastric Preneoplasia
Goldenring Lab | December 2, 2025
Pan-Cancer Analyses Reveal Disparities in Tumor Genomic Profiles by Race/Ethnicity, Age, and Sex
Singh & Park Labs | December 1, 2025
Efficacy, safety, and predictive biomarkers of neoadjuvant nab-paclitaxel and pembrolizumab in hormone receptor-positive breast cancer: A randomized pilot trial
Balko Lab | November 28, 2025
Clonal Hematopoiesis of Indeterminate Potential Influences Breast Cancer Outcomes in a Genotype-Specific Manner
Hurley, Ferrell, Park Labs | November 14, 2025
TREM2 expressing macrophages are not associated with prognostic markers or metabolic syndrome in early stage ER positive breast cancer
Fingleton & Hasty Labs | November 6, 2025
Distinct and convergent effects of SF3B1 mutations in human breast cancer
Shyr, Hurley, Park Labs | October 14, 2025
MDR1 promotes CD8 T cell persistence in tumors and protects against cytotoxic chemotherapy
Philip Lab | September 30, 2025
Tumor-specific major histocompatibility-II expression predicts pathological complete response to atezolizumab combined to chemotherapy in triple-negative breast cancer
Balko Lab | September 29, 2025
Phase Ib Trial of Fulvestrant, Palbociclib, and Erdafitinib, a pan-FGFR Tyrosine Kinase Inhibitor, in HR+/HER2- Metastatic Breast Cancer
Balko & Park Labs | September 2, 2025
Fluorescence-Guided Surgery for Assessing Margins in Head and Neck Cancer: A Review
Rosenthal Lab | September 1, 2025
Locally Reprogramming Tumor-Associated Macrophages with Cytokine-Loaded Injectable Cryogels for Breast Cancer
Rafat, Hurley, Yull, Griogio Labs | August 29, 2025
Neck Dissection Reduces Risk of Recurrence in Early-Stage Oral Tongue Cancer
Rosenthal Lab | August 28, 2025
Protective role of epithelial deoxyhypusine synthase in colorectal carcinogenesis caused by deletion of the adenomatous polyposis coli gene
Coburn & K. Wilson Labs | August 24, 2025
Identification of asporin as a HER3 ligand exposes a therapeutic vulnerability in prostate cancer
Park & Hurley Labs | August 22, 2025
Programmed cell death protein 1 (PD-1) blockade regulates skeletal remodeling in a sex- and age-dependent manner
Rosenthal & Johnson Labs | July 28, 2025
Loss of IL13RA2 promotes metastatic tumor growth in triple-negative breast cancer via increased AKT and NF-κB signaling
Rafat & Fingleton Labs | July 15, 2025
Early-Onset Colorectal Cancer: From Genetic Discovery to Clinical Innovation
Holowatyj Lab | July 10, 2025
Hsp47 drives obesity-associated breast cancer progression by enhancing asporin deposition in adipose tissue
Hurley Lab | July 6, 2025
Fabrication of RIG-I-Activating Nanoparticles for Intratumoral Immunotherapy via Flash Nanoprecipitation
J. Wilson Lab | July 1, 2025
Exosomes are specialized vehicles to induce fibronectin assembly
Weaver Lab | June 24, 2025
A phase Ib/II trial of atezolizumab with cobimetinib or idasanutlin in metastatic estrogen receptor positive breast cancer
Balko Lab | June 21, 2025
Birth Cohort Effects in Appendiceal Adenocarcinoma Incidence Across the United States
Holowatyj Lab | June 10, 2025
KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavage
Balko Lab | June 2, 2025
Molecular imaging predicts trastuzumab-deruxtecan (T-DXd) response in head and neck cancer xenograft models
Rosenthal Lab | May 28, 2025
Reprogramming the neuroblastoma tumor immune microenvironment to enhance GPC2 CAR T cells
J. Wilson Lab | May 27, 2025
Targeting Tumor Stroma in CMS4 Colorectal Cancer: Phospholamban Takes Center Stage
Williams Lab | May 21, 2025
Abaloparatide increases bone mass without affecting growth of bone-disseminated cancer cells
Johnson Lab | May 2, 2025
Neoadjuvant Radiotherapy vs Up-Front Surgery for Resectable Locally Advanced Rectal Cancer
Shyr Lab | May 1, 2025
Chronic Cigarette Smoke Exposure Masks Pathological Features of Helicobacter pylori Infection While Promoting Tumor Initiation
Peek Lab | May 1, 2025
Biomarker-informed care for patients with renal cell carcinoma
Haake Lab | April 16, 2025
Results of the Phase I/II Study and Preliminary B-cell Gene Signature of Combined Inhibition of Glutamine Metabolism and EGFR in Colorectal Cancer
Shyr Lab | April 14, 2025
Increased fatty acid delivery by tumor endothelium promotes metastatic outgrowth
Boothby & Chen Labs | April 8, 2025
Comparison of Lean, Obese, and Weight-Loss Models Reveals TREM2 Deficiency Attenuates Breast Cancer Growth Uniquely in Lean Mice and Alters Clonal T-cell Populations
Pietenpol, J. Rathmell, Fingleton, Hasty Labs | April 3, 2025
Dipeptidase-1-knockout mice develop invasive tumors with features of microsatellite-unstable colorectal cancer
Markham & Coffey Labs | April 3, 2025
In Situ Detection of Individual Classic MHC-I Gene Products in Cancer
Balko Lab | April 2, 2025
Conserved spatial subtypes and cellular neighborhoods of cancer-associated fibroblasts revealed by single-cell spatial multi-omics
Hwang Lab | March 27, 2025
Progesterone receptor-dependent downregulation of MHC class I promotes tumor immune evasion and growth in breast cancer
Balko Lab | March 18, 2025
Cortactin Facilitates Malignant Transformation of Dysplastic Cells in Gastric Cancer Development
Weaver Lab | March 5, 2025
Hepatic Stellate Cells Functional Heterogeneity in Liver Cancer
Y. Lee Lab | March 5, 2025
Comparative performance analysis of neoepitope prediction algorithms in head and neck cancer
Joyce Lab | March 4, 2025
Peripheral blood biomarkers in monitoring treatment response in breast cancer patients
Balko Lab | February 18, 2025
Olaparib in treatment-refractory isocitrate dehydrogenase 1 (IDH1)- and IDH2-mutant cholangiocarcinoma: Safety and antitumor activity from the phase 2 National Cancer Institute 10129 trial
Shyr Lab | February 15, 2025
Tenascin-C Potentiates Wnt Signaling in Thyroid Cancer
E. Lee & Weiss Labs | February 5, 2025
Benchmarking Spatial Co-Localization Methods for Single-Cell Multiplex Imaging Data with Applications to High-Grade Serous Ovarian and Triple Negative Breast Cancer
Coffey Lab | January 15, 2025
Highly multiplexed imaging reveals prognostic immune and stromal spatial biomarkers in breast cancer
Pietenpol Lab | January 14, 2025
Unleashing Wnts: Wnt Ligands Fuel Cancer Spread
E. Lee & Weiss Labs | 2025
2024
Tuft cells transdifferentiate to neural-like progenitor cells in the progression of pancreatic cancer
DelGiorno Lab | December 24, 2024
Elucidating Sex-Specific Immune Profiles in a Breast Cancer Model
Fingleton Lab | December 6, 2024
The influence of endothelial metabolic reprogramming on the tumor microenvironment
Chen Lab | November 20, 2024
Immigrant Health and Early-Onset Colorectal Cancer Disparities: Results From the Spanish Early-Onset Colorectal Cancer Consortium
Holowatyj Lab | November 10, 2024
Tenascin-C potentiates Wnt signaling in thyroid cancer
Hurley, E. Lee, Weiss Labs | November 6, 2024
VISTA-mediated immune evasion in cancer
Kim Lab | November 1, 2024
ERBB2 amplification in gastric cancer: a genomic insight into ethnic disparities
Holowatyj Lab | November 1, 2024
Visual pathology reports for communication of final margin status in laryngeal cancer surgery
Rosenthal Lab | October 28, 2024
Ultrafast power doppler ultrasound enables longitudinal tracking of vascular changes that correlate with immune response after radiotherapy
Rafat Lab | October 21, 2024
Vaccination generates functional progenitor tumor-specific CD8 T cells and long-term tumor control
Philip Lab | October 3, 2024
Digital mapping of resected cancer specimens: The visual pathology report
Rosenthal Lab | September 28, 2024
Trem2 deficiency attenuates breast cancer tumor growth in lean, but not obese or weight loss, mice and is associated with alterations of clonal T cell populations
Pietenpol, J. Rathmell, Fingleton, Hasty Labs | September 27, 2024
STING-Activating Polymer-Drug Conjugates for Cancer Immunotherapy
J. Wilson Lab | September 25, 2024
Interim Phase II Results Using Panitumumab-IRDye800CW during Transoral Robotic Surgery in Patients with Oropharyngeal Cancer
Rosenthal Lab | September 13, 2024
Associations of Immune Checkpoint Predictive Biomarkers (MHC-I and MHC-II) with Clinical and Molecular Features in a Diverse Breast Cancer Cohort
Balko Lab | September 13, 2024
Visual pathology reports for improved collaboration at multidisciplinary head and neck tumor board
Rosenthal Lab | August 29, 2024
Jump-starting chimeric antigen receptor-T cells to go the extra mile with nanotechnology
J. Wilson Lab | August 20, 2024
Extracellular RNA in oncogenesis, metastasis and drug resistance
Coffey & Weaver Labs | August 6, 2024
Transfer of miR-100 and miR-125b increases 3D growth and invasiveness in recipient cancer cells
Weaver, Rafat, Coffey Labs | July 29, 2024
Efficacy of depatuxizumab mafodotin (ABT-414) in preclinical models of head and neck cancer
Rosenthal Lab | July 8, 2024
The Roles of RAC1 and RAC1B in Colorectal Cancer and Their Potential Contribution to Cetuximab Resistance
Singh Lab | July 6, 2024
Infrared Fluorescence-guided Surgery for Tumor and Metastatic Lymph Node Detection in Head and Neck Cancer
Rosenthal Lab | July 2024
Development of a plant-based surgical training model for fluorescence-guided cancer surgery
Rosenthal Lab | June 6, 2024
Chronic High-Salt Diet Activates Tumor-Initiating Stem Cells Leading to Breast Cancer Proliferation
Zent, Lannigan, J. Rathmell Labs | May 25, 2024
Resolution of Acinar Dedifferentiation Regulates Tissue Remodeling in Pancreatic Injury and Cancer Initiation
DelGiorno Lab | May 9, 2024
Programable Albumin-Hitchhiking Nanobodies Enhance the Delivery of STING Agonists to Potentiate Cancer Immunotherapy
John Wilson, Rathmell, Richmond, Balko, FIngleton Labs | May 8, 2024
Epithelial Expressed B7-H4 Drives Differential Immunotherapy Response in Murine and Human Breast Cancer
J. Wilson, Pietenpol, Balko Labs | April 24, 2024
Type II Interleukin-4 Receptor Activation in Basal Breast Cancer Cells Promotes Tumor Progression via Metabolic and Epigenetic Modulation
Fingleton Lab | April 24, 2024
Nanoparticle Retinoic Acid-Inducible Gene I Agonist for Cancer Immunotherapy
Richmond & J. Wilson Labs | April 24, 2024
Tuft cells transdifferentiate to neural-like progenitor cells in the progression of pancreatic cancer
DelGiorno Lab | April 23, 2024
VHL loss reprograms the immune landscape to promote an inflammatory myeloid microenvironment in renal tumorigenesis
Haake, Weiss, K. Rathmell, J. Rathmell Labs | April 15, 2024
EMP2 Serves as a Functional Biomarker for Chemotherapy-Resistant Triple-Negative Breast Cancer
Balko Lab | April 12, 2024
Multiparametric Single-Vesicle Flow Cytometry Resolves Extracellular Vesicle Heterogeneity and Reveals Selective Regulation of Biogenesis and Cargo Distribution
J. Wilson & Weaver Labs | April 5, 2024
The Hallmarks of Precancer
Coffey Lab | April 4, 2024
Regulation of fatty acid delivery to metastases by tumor endothelium
Boothby & Chen Labs | April 3, 2024
Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia
J. Rathmell & Savona Labs | April 1, 2024
The mitochondrial fission protein DRP1 influences memory CD8+ T cell formation and function
Mason Lab | March 29, 2024
Polygenic risk score for ulcerative colitis predicts immune checkpoint inhibitor-mediated colitis
Lovly & Balko Labs | March 26, 2024
PARP14 Contributes to the Development of the Tumor-Associated Macrophage Phenotype
Boothby Lab | March 22, 2024
Mammary tissue-derived extracellular matrix hydrogels reveal the role of irradiation in driving a pro-tumor and immunosuppressive microenvironment
Rafat Lab | March 21, 2024
Multiomic profiling of human clonal hematopoiesis reveals genotype and cell-specific inflammatory pathway activation
Savona & Ferrell Labs | March 20, 2024
A Cancer Nanovaccine for Co-Delivery of Peptide Neoantigens and Optimized Combinations of STING and TLR4 Agonists
Joyce & J. WIlson Labs | March 5, 2024
Vaccination generates functional progenitor tumor-specific CD8 T cells and long-term tumor control
Philip Lab | February 29, 2024
PTHrP intracrine actions divergently influence breast cancer growth through p27 and LIFR
Johnson Lab | Febriary 26, 2024
A Large-Scale Meta-Analysis Reveals Positive Feedback between Macrophages and T Cells That Sensitizes Tumors to Immunotherapy
Shyr Lab | February 15, 2024
Tumor therapy by targeting extracellular hydroxyapatite using novel drugs: A paradigm shift
Rhoades & Fingleton Labs | February 2024
NKG2A Is a Therapeutic Vulnerability in Immunotherapy Resistant MHC-I Heterogeneous Triple-Negative Breast Cancer
Pietenpol & Balko Labs | February 8, 2024
Distinct roles for interleukin-23 receptor signaling in regulatory T cells in sporadic and inflammation-associated carcinogenesis
Williams, Markham, Goettel Labs | February 5, 2024
Endogenous pAKT activity is associated with response to AKT inhibition alone and in combination with immune checkpoint inhibition in murine models of TNBC
Richmond Lab | February 2, 2024
Atezolizumab in Combination With Carboplatin and Survival Outcomes in Patients With Metastatic Triple-Negative Breast Cancer
Shyr & Pietenpol Labs | February 1, 2024
TBCRC 039: a phase II study of preoperative ruxolitinib with or without paclitaxel for triple-negative inflammatory breast cancer
Balko Lab | January 31, 2024
FindAdapt: A python package for fast and accurate adapter detection in small RNA sequencing
Shyr Lab | January 22, 2024
Inhibition of autocrine HGF maturation overcomes cetuximab resistance in colorectal cancer
Coffey & Singh Labs | January 12, 2024
Epigenetic control of the vicious cycle
Johnson Lab | January 12, 2024
Genomic dissection and mutation-specific target discovery for breast cancer PIK3CA hotspot mutations
Park Lab | Janaury 4, 2024
2023
A Phase 1/2 Study to Evaluate the Safety and Activity of Nivolumab in Combination With Vorolanib, a Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor, in Patients With Refractory Thoracic Tumors
Shyr Lab | December 15, 2023
Clinical Pathogenesis, Molecular Mechanisms of Gastric Cancer Development
Peek Lab | 2023
Polycomb repressor complex 2 suppresses interferon-responsive MHC-II expression in melanoma cells and is associated with anti-PD-1 resistance
Balko Lab | November 20, 2023
Development of an alginate-Matrigel hydrogel system to evaluate cancer cell behavior in the stiffness range of the bone marrow
Rhoades & Rafat Labs | June 2, 2023