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Science Hour

All Science Hours are Wednesday at 4:00 p.m. in PRB 898J, unless otherwise noted.

Winter-Spring 2018

Jan 17, 2018
Targeting mLST8 in mTORC2-dependent lung cancer
Laura Kim, Graduate Student, Chen Lab
Rescheduled: Pathological regulation of Wnt signaling at the membrane
Ethan Lee, M.D./Ph.D. Professor, Cell & Developmental Biology

Jan 24, 2018
BVES regulation of Wnt Signaling and Intestinal Tumorigenesis
Joshua J. Thompson, MSTP Student, Williams Lab
Rescheduled: To divide or die: Cellular Response Under Continued Drug Perturbations  
Bishal Paudel Ph.D., Post-doctoral Fellow, Quaranta Lab

Jan 31, 2018
ERK1/2-RSK2 negatively regulates estrogen responsiveness in the adult
Zachary M. Sandusky, Graduate Student, Lannigan Lab
Principles of Cancer Biology Applied to Non-Cancer Diseases
Joshua P. Fessel M.D./Ph.D., Assistant Professor of Medicine, Pharmacology, and Cancer Biology

Feb 7, 2018
Harnessing NK cell innate immunity to overcome resistance to checkpoint inhibition in TNBC
Eileen Shiuan, MSTP Student, Chen Lab
Cellular Response Under Continued Drug Perturbations  
Bishal Paudel, Ph.D., Post-doctoral Fellow, Quaranta Lab

Feb 14, 2018
Tumor Cell Response to the Physical Bone Microenvironment
Kristin Kwakwa, Graduate Student, Sterling Lab
Building a Better T Cell to Fight Cancer
Jeffrey Rathmell, Ph.D., Professor Dept. Pathology, Microbiology & Immunology

Feb 21, 2018
Stratifying glioblastoma with signaling and single cell biology
Nalin Leelatian, M.D., Graduate Student, Irish Lab
Regulation of tumor blood vessel normalization by mTORC1
Jin Chen M.D./Ph.D., Professor of Medicine, and Cell & Developmental Biology

Feb 28, 2018
Dissecting brain tumor response to stem cell niche factors at single-cell resolution
Justine Sinnaeve, Graduate Student, Ihrie Lab
Autocrine and paracrine roles of exosomes in cancer cell migration
Alissa Weaver M.D., Ph.D., Department of Cell and Developmental Biology

March 7, 2018
Therapeutically active RIG-I agonist induces immunogenic tumor cell killing in breast cancers
David Elion, Graduate Student, Cook Lab
Rewiring tumor-specific T cells into cancer killers
Mary Philip M.D., Ph.D, Assistant Professor of Medicine and Pathology, Microbiology & Immunology

March 14, 2018
No Science Hour

March 21, 2018
Renal Cell Carcinoma Exosomes: Mediators of Immune Suppression
Aaron Lim, Graduate Student, Rathmell Lab
Exploring Metastatic Mechanisms
Barbara Fingleton Ph.D., Assistant Professor Pharmacology and Surgery

March 28, 2018
A role for metabolic regulator AMPK in humoral immunity
Shawna McLetchie, Graduate Student, Boothby Lab
Pathological regulation of Wnt signaling at the membrane
Ethan Lee, M.D./Ph.D. Professor, Cell & Developmental Biology

April 4, 2018

Scott Haake M.D., Graduate Student, Research Instructor Hemacology/Oncology
Macrophages Promote Circulating Tumor Cell-Mediated Local Recurrence Following Radiation Therapy
Marjan Rafat Ph.D., Assistant Professor Chemical and Biomolecular Engineering

Fall-Winter 2017

September 27, 2017
The role of TGF-B responsive myeloid cell in tumor-induced bone disease.
Denise Buenrostro, Graduate Student, Sterling Lab
Translational Immuno-oncology research: identifying new combinations for the treatment of cancer
Justin M. Balko, Pharm.D. Ph.D, Assistant Professor, Department of Medicine, VUMC, Leader of Molecular Oncology, Center for Cancer-Targeted Therapies

October 4, 2017
Understanding Outcomes following Stem Cell Transplant for Hematologic Malignancies: A Machine Learning Approach
Jocelyn Gandelman, Medical Student, Irish & Jagasia Laboratories
Breast cancer dormancy: What’s bone got to do with it?
Rachelle Johnson Ph.D., Assistant Professor, Medicine

Oct 11, 2017
No Science Hour

Oct 18, 2017
Systems based analysis of melanoma after targeted therapy reveal loss of neural crest identity and MHC I as potential therapeutic opportunities
Deon Doxie, Graduate Student, Irish Laboratory
From patients to cell biology and back: using cytometry to reveal relationships between the stem cell niche and brain tumors
Rebecca Ihrie Ph.D. Assistant Professor, Cell & Developmental Biology

Oct 25, 2017
Alternative splicing of ALCAM enables tunable regulation of cell:cell adhesion through differential proteolysis
Katie Hebron, Graduate Student, Zijlstra Lab
Tumor-Induced Bone Disease
Julie Sterling Ph.D., Assistant Professor of Medicine, Division of Clinical Pharmacology & Biomedical Engineering

Nov 1, 2017
Histone deacetylase inhibitors stimulate LIFR and pro-dormancy gene expression in breast cancer cells that home to the bone
Miranda Sowder, Graduate Student, Johnson Lab
Integration of multiple quantitative platforms to understand cellular response to extrinsic perturbations
Carlos Lopez PhD, Assistant Professor of Biochemistry

Nov 8, 2017
Quantifying synergy of efficacy and synergy of potency in drug combinations for cancer therapy David Wooten, Graduate Student, Quaranta Lab
Quantifying Changes in Cell Identity in Clinical Studies of Human Tumors and Tissue
Jonathan Irish PhD, Assistant Professor of Cell & Developmental Biology, Pathology, Microbiology, & Immunology

Nov 15, 2017
PIK3CA C2 domain deletions hyperactivate phosphoinositide 3-kinase (PI3K), generate oncogene dependence and are sensitive to PI3Ka inhibitors
Sarah Croessmann PhD, Post-Doctoral Fellow, Arteaga Lab
Targeted therapies that enhance response to immune therapy
Ann Richmond PhD, Professor of Pharmacology

Nov 22, 2017
No Science Hour
Happy Thanksgiving!

Nov 29, 2017
Epithelial-mesenchymal transition in ALK-TKI resistant lung adenocarcinoma
Karinna Almodovar PhD, Post-Doctoral Fellow, Lovly Lab
Taking out the trash
Rebecca Cook PhD, Assistant Professor of Cell & Developmental Biology and Biomedical Engineering

Dec 6, 2017
Insights into Kinase Fusion Biology Through Investigation of the 5’ Partner
Merrida Childress, Graduate Student, Lovly Lab
Macrophage-based immunotherapy: Rehab for "bad guys" in the tumor microenvironment
Fiona Yull PhD, Associate Professor of Pharmacology

Dec 13, 2017
The USP46 complex potentiates Wnt signaling by blocking receptor turnover
Victoria Ng, Graduate Student, Lee Lab
Immunotherapy & Radiotherapy for Prostate Cancer Treatment
Austin Kirschner MD/PhD, Assistant Professor Radiation Oncology

December 20, 2017
Winter Break.  Happy Holidays!

January 10, 2017