Job Opportunity: Research Fellow, Brown Lab, VUMC, Nashville, TN
The Brown Laboratory studies how chromatin-dependent signaling controls pathologic gene expression in cardiometabolic diseases and vascular aging. In particular, our group focuses on how BET bromodomain-containing “reader” proteins regulate transcription in response to stress signals in endothelial cells, vascular smooth muscle cells and macrophages. We have discovered that selective inhibition of BETs can reduce atherosclerosis in murine models of disease. These data identify a novel therapeutic approach to drug pathologic transcription by targeting specific chromatin-associated coactivator proteins. More recently, we have used genome-wide maps of chromatin coactivator occupancy coupled with gene expression profiles to predict gene regulatory circuits that drive changes in cell state in cardiovascular disease.
Our group is seeking a highly motivated postdoctoral research fellow who can leverage cell biology approaches and murine models of disease to study how cell-type specific gene activation is controlled during atherosclerosis and vascular aging. Cutting-edge next-generation sequencing (NGS) assays including single-cell RNA-seq, ChIP-seq and ATAC-seq will be used to define the gene regulatory circuits activated during initiation and progression of vascular disease. Ultimately, the goal of this work is to discover and experimentally validate previously unidentified transcriptional regulators involved in cardiovascular disease.
Please email your cover letter and curriculum vitae to Jonathan Brown along with the names and contact information for 3 references.
please also visit our lab website: jonbrownlab.com for more information.