Multiple Postdoctoral Fellow Career Opportunities at Cold Spring Harbor Laboratory! – Laurel Hollow, NY
The Cheadle Lab at Cold Spring Harbor Laboratory is inviting applications from highly motivated candidates for a postdoctoral position investigating interactions between neurons and immune cells (microglia) in the developing brain. We employ a unique multidisciplinary strategy to study these interactions that merges two-photon imaging in the brains of live awake mice, single-cell or low input genomics, and standard molecular and cell biological approaches.
Join a team of biological data scientists working on novel statistical methods and computational algorithms for multi-omics processing and integration, and leverage Big Genomic Data to elucidate various problems in precision health, such as genetic and epigenetic mechanisms of cancer development and progression, and the clinical impact of functional variants.
We are looking for theoretical/computational scientists to work at the exciting interface of systems neuroscience, machine learning, and statistical physics, in close collaboration with experimentalists. The postdoctoral scientist is expected to exhibit resourcefulness and independence, developing computational models of large-scale neural activity recordings with the goal to elucidate neural circuit mechanisms underlying cognitive functions.
The Furukawa lab has NIH-funded postdoctoral fellow/associate positions available for scientists interested in solving questions in neurobiology and neuro-cancer-immunology by implementing a dynamic range of techniques including structural biology (cryo-EM, x-ray crystallography, molecular dynamics) together with electrophysiology (patch-clamp, slice physiology, lipid bilayer), protein engineering, chemical biology, mouse model, cellular imaging, and cancer mouse model. underlying cognitive functions.
Postdoctoral Fellow – Janowitz Lab – 02988-R
The Janowitz Laboratory at CSHL is seeking a highly motivated, creative, and interactive postdoctoral researcher with strong experimental and analytical skills to contribute to research on the connectivity of the host response to cancer. We employ pre-clinical and clinical research to develop and test new treatment strategies and to discover fundamental biological interactions between tumors and host organ systems.
Joint Postdoctoral Fellow –Borniger Lab Janowitz Lab Lukey Lab
Together, the Borniger, Lukey, and Janowitz laboratory at Cold Spring Harbor Laboratory (CSHL) offer a unique opportunity for a highly motivated and creative postdoctoral researcher, with strong experimental and analytical skills, to investigate the reciprocal interaction of sleep and cancer progression. You will become part of a multidisciplinary team of basic researchers and clinicians studying tumor-host interactions, using integrative techniques from neuroscience, endocrinology, metabolomics, and immunology to dissect the mechanisms connecting sleep disruption with aberrant metabolic and immune responses during cancer progression.
We are currently seeking innovative, inventive, and self-driven Postdoctoral Associates within the lab of Dr. Leemor Joshua-Tor at Cold Spring Harbor Laboratory. The Joshua-Tor lab studies the structure and mechanism of gene silencing pathways as well as DNA replication. To get a complete understanding of how these processes, the team employs structural, biochemical, biophysical and molecular biology approaches to study how key proteins work at the molecular level. More information can be found on their website.
The research of the Lab centers on normal and malignant stem and progenitor cells in the hematopoietic system and decodes the role of metabolites, including micronutrients and neurotransmitters, in the tumor microenvironment and their genetic effectors in regulating hematologic malignancies. The Lab utilizes a combination of CRISPR/Cas functional genomics and metabolomics approaches to systematically uncover the critical metabolites and their genetic effectors, including receptors and metabolic enzymes, to reveal mechanistic insights of and identify key drug targets for hematologic malignancies. The ultimate goal is to understand how environmental signals such as diets and nervous system activities modulate blood cell development and cancers. Based on these basic mechanistic insights, the Lab is building innovative therapeutics to treat hematopoietic malignancies that are currently without effective therapeutic options.
Justin B. Kinney and Adrian R. Krainer seek a postdoctoral fellow to spearhead a project focused on quantitative signal integration in alternative mRNA splicing. This position is part of an ongoing collaboration between the Kinney Lab and Krainer Lab, the goal of which is to understand the readout of pre-mRNA sequence by snRNPs and RBPs, as well as the effects of splice-modifying drugs. The successful candidate will be expected to help design their project’s aims and to lead the necessary experimental work. These studies will primarily focus on splicing in human cell culture and/or in vitro splicing reactions, and will involve a combination of both low-throughput and high-throughput techniques, including massively parallel reporter assays (MPRAs). Novel experimental techniques will be developed as needed.
The successful candidate will develop new statistical and mathematical techniques for modeling the effects of mutations and will conduct analyses on a variety of data sets. Current research directions involve semi-parametric statistics, Markov chains, Gaussian processes, and population-genetic theory.
The Meyer lab in the Simons Center for Quantitative Biology at Cold Spring Harbor Laboratory is looking for post-doctoral fellows interested in combining computational and experimental approaches to study the genetics of human T cell development. We have two, fully funded positions, with either a focus on experimental immunology or quantitative genetics and data analyses. Experience in both areas would be welcome, but sufficient enthusiasm and excitement to learn can replace lack of experience. Both projects revolve around the genetics of T cell development and immune cell function during childhood and their link to the genetics of immune-mediated diseases. Successful candidates will work as part of a larger interdisciplinary team of computational and experimental scientists and in collaboration with clinical investigators. For more information on our research program, see https://meyer-lab-cshl.github.io/
Joint Postdoctoral Fellow – Meyer Lab & Navlakha Lab – 02556-R
The Meyer and Navlakha labs in the Simons Center for Quantitative Biology at Cold Spring Harbor Laboratory are looking for a post-doctoral fellow interested in combining computational and experimental approaches to study tolerance induction and generation of diversity in the immune system. Computationally, the position will require experience in machine learning and statistics. Experimentally, the position will require experience in in vitro imaging combined with cell tracking experiments and tissue culture.
We are looking for post-docs broadly interested in studying biological information processing from an algorithmic perspective. The goal is to discover new ideas for computation by studying problem-solving strategies used in nature, and to ground these ideas by fostering deep collaborations with experimental biologists. Most recently, we have been interested in neural circuit computation and plant architecture optimization, but new areas are also welcome!
The main focus of research will be to study the roles of genes associated with human diseases in the development and function of neural circuits, using molecular, genetic and viral engineering, optogenetics, imaging, electrophysiology, and behavior analysis.
We are interested in how small RNAs identify and silence transposable elements when they become active during mammalian development and disease. This is an exciting new field with many opportunities! We believe tRFs are an ancient link between RNAi, transposons and genome stability.
A postdoctoral position is available, in the laboratory of Dr. David L. Spector at Cold Spring Harbor Laboratory, for a highly motivated outstanding individual to study long non-coding RNAs (lncRNAs) in breast cancer progression using patient-derived organoids as a model system. LncRNAs are an exciting class of thousands of RNAs among which very few have thus far been functionally characterized. We recently performed an RNA-seq screen in patient-derived breast tumor organoids and identified lncRNAs over-expressed in tumor organoids vs normal. The proposed studies will interrogate the functional role of specific lncRNAs in breast cancer initiation, progression, and metastasis, as well a their potential as therapeutic targets. Experience in breast cancer, molecular biology, extensive genomic analysis, organoids, and mouse models is a plus.
The Wigler and Levy research group are seeking a Computational Post Doc that will have a key role in a multi-disciplinary team of wet-bench and computational researchers working to revolutionize cancer detection and treatment by developing novel genomic technologies. We are re-envisioning the tools of genetics research by coupling innovation at the bench with novel computational methods. We have developed methods for inexpensive copy number (SMASH), generating long reads from short-read sequencers (muSeq), encapsulation of cells in acrylamide gel (BAG-seq), sensitive detection of cancer genomes (MASQ), and most recently mutational sequencing for short tandem repeats (muSTR). Applicants may review our most recent publications at http://wigserv2.cshl.edu/doku.php?id=publications.
The Yeh Laboratory at CSHL Cancer Center (http://yehlab.labsites.cshl.edu) is seeking for a qualified postdoctoral fellow passionate about biotherapeutics discovery and engineering. The Yeh Lab is a highly-collaborative environment with state-of-the-art facilities and expertise in biotherapeutics engineering and chemical biology.
To learn more about these positions and others available at CSHL follow us on Twitter @CSHLCareers or to apply, please visit us at https://www.cshl.edu/about-us/careers/postdoc-positions/
CSHL offers a competitive salary and comprehensive benefits program, including medical and dental insurance, and access to an affordable and licensed on-site childcare center. In addition, CSHL Meetings and Courses program provides an opportunity for interacting with a broad range of researchers and exposure to timely advances in many areas of scientific research.