Postdoc Position: Immunobiology of MAIT cells in Intestinal Infection and Inflammation
In the Department of Pathology at Brigham and Women’s Hospital and Harvard Medical School, Boston, MA USA
Our laboratory studies the immunobiology of innate T cells, including NKT and MAIT cells. Current projects aim to understand the mechanisms that activate MR1-restricted Mucosal-Associated Invariant T (MAIT) cells and their role and functions during homeostasis, intestinal infection and inflammation. We are particularly interested in understanding how MAIT cells recognize MR1-presented microbial metabolite antigens; the antigenindependent mechanisms that regulate MAIT cell activation, including the role of critical antigen presenting cells; the consequences of MAIT cell activation and their effector functions, including interactions with other immune and non-immune cells; and in developing preventive and therapeutic strategies that target MAIT cells. We are using cutting edge molecular biology, cellular immunology, and advanced chemistry techniques, in combination with several novel genetically modified in vivo mouse models. We collaborate extensively with local, national and international research groups. For more info on the Brigl lab, please visit: http://brigl.bwh.harvard.edu/
This position provides an opportunity to build a highly novel set of skills and expertise using cutting edge technologies, and to work in a highly dynamic research environment. The lab and department are in close proximity to the rich and innovative research environment within the Harvard and wider Boston research communities. The successful applicant is highly self-motivated, able to work independently and in collaborative relationships within the lab and with our outside collaborators, and has experience working with mouse models. Applicants must have a M.D. degree or a Ph.D. degree in the area of immunology that was awarded within the last three years. Stipends will be in accordance with NIH and institutional guidelines. Funding for this position is for two years with opportunity for renewal. If you are interested in this position, please submit a CV; a brief description of your background, research accomplishments, interests, and career goals; contact information of three references who are familiar with your work; and pdfs of any relevant publications to: firstname.lastname@example.org.
Manfred Brigl, M.D.
Assistant Professor in Pathology
Brigham and Women’s Hospital
77 Avenue Louis Pasteur
New Research Building, Rm 730E
Boston, MA 02115