A post-doctoral position is available to study mechanisms by which the peptide hormone apelin and its receptor influence cardiovascular and metabolic homeostasis. The laboratory currently has two extramurally funded projects in this area: 1) identification of signaling pathways underlying the pro-angiogenic effects of apelin and 2) development of apelin receptor antagonists for therapeutic applications. Post-doctoral research will include experimental design and execution, and interpretation of results obtained using various in vitro assays with the goal of defining the molecular pathways regulated by apelin, as well as characterizing the pharmacology and mechanism of action of novel small molecule antagonists of the apelin receptor. These projects combine state-of-the-art approaches for determining receptor pharmacology, and mechanistic studies using molecular biology and cell-based assays. It is anticipated that the successful post-doctoral research associate will interface with the broader research group to advance related projects within the group.
Sanford-Burnham Medical Research Institute at Lake Nona (Orlando) is an independent, not-for-profit biomedical research institution dedicated to advancing the frontiers of scientific knowledge in life sciences and medicine with an emphasis on research on Diabetes and Obesity. The Lake Nona/Orlando site has several outstanding technology cores for modern molecular and chemical biology research, with a strong interdisciplinary collaborative approach to scientific study. There are also opportunities for clinical/translational studies via a strong collaborative interaction between the Sanford-Burnham Lake Nona site and the Translational Research Institute for Metabolism and Diabetes at the Florida Hospital.
Candidates must have a Ph.D. and/or M.D. and a strong background in one of the following areas: vascular biology, cell/molecular biology, pharmacology. Experience with transgenic mouse models, and/or in vitro and in vivo angiogenesis assays is a plus. It is important that the candidate have excellent communication and interpersonal skills and the ability to work within an interdisciplinary team.
Interested applicants should submit a cover letter indicating research accomplishments and interests, CV, and contact information for at least 3 references as a single PDF or Word document to: email@example.com
6400 Sanger Road
Orlando, FL 32827
407. 745. 2000