Postdoctoral Research Fellowship in Mass Spectrometry, Proteomics and Bioinformatics of Kidney Disease at Center for Matrix Biology - Division of Nephrology - Vanderbilt University, Nashville TN
A NIH-funded postdoctoral fellow position is available immediately to develop and apply mass spectrometry-based proteomics methodologies for the study of kidney disease in the division of nephrology at Vanderbilt University. The major goal is to gain a better understanding of the molecular mechanisms contributing to renal fibrosis in diabetic nephropathy. Projects for this positions will specifically focus on: 1) determining key structural features of collagen IV scaffolds with a particular focus on identification and characterization of novel posttranslational modifications and 2) to perform proteomics analyses in mouse and human renal samples to identify biomarkers for detection at an early stage or prediction of diabetic nephropathy. A special emphasis will be given to explore the extracellular matrix of the kidney. The work will be performed in collaboration with the Proteomics Lab and will make use of the state of the art facilities available at the Mass Spectrometry Research Center, which provides excellent opportunities to receive advanced training and expand previous knowledge in a mass spectrometry and proteomics technologies.
We are seeking a highly motivated recent PhD graduate with a strong background in protein biochemistry and mass spectrometry-based proteomics. Execution of the projects will require extensive experience in purification of proteins and peptides by HPLC, knowledge of sample preparation for MS analysis and data analysis. Candidates with proven experience with proteomics technology and associated bioinformatics and biostatistics tools for global analysis of large data sets will be preferred. Proficiency in the use of software for the identification and quantitation of posttranslational modifications is desirable. Previous experience with stable isotope labeling in culture and label-free targeted methods are highly desirable. Ability to think and work independently and a critical mindset are key features for a successful applicant. Excellent written and verbal communication skills are required. Preference will be given to individuals with the initiative and talent to lead projects and the motivation and ambition to publish first authored papers.
This is a full-time position that requires a PhD degree (Biochemistry, Chemistry, Analytical Chemistry, or related discipline). Salary is based on NIH pay scale. Vanderbilt offers excellent benefits including a great retirement plan, health and dental insurance, etc.
Please submit a cover letter, current CV, publications reprints and at least 3 references to:
Dr. Roberto Vanacore
Department of Medicine-Division of Nephrology