Dr. Claudia Kemper\u2019s laboratory (Complement and Inflammation Research Section \u2013 CIRS), which is located, in\u00a0the Immunology Center of the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of,Health (NIH), is recruiting a postdoctoral researcher with strong immunological expertise, specifically related
\nto in vivo mouse models of infection and\/or autoimmunity.
\nOur laboratory focuses on the new and non-canonical roles of intracellularly functioning innate immunity (complement) in the regulation of both innate and adaptive immune responses. For example, we have, previously shown that intracellular complement is critical to the normal induction and contraction of Th1 responses via regulation of key nutrient influx and metabolic pathways in CD4+ T cells and that deviations in this \u2018pathways\u2019 underlie recurrent infections and autoimmune disease (Liszewski et al., Immunity, 2013; Kolev et al., Immunity, 2015; Arbore et al., Science, 2016). We have extended our discovery in T cells and
\nhave also demonstrated that intracellular complement is operative across other immune (monocytes\/macrophages, B cells, etc.) and non-immune cells (Kolev et al. Immunity 2020, Niyonzima et al, Sci Immunol, 2021; West et al, Immunity, 2023) where it is critical for the control of basic cell physiological processes, such as gene transcription and protein translation, control of the mitochondrial electron transport chain and amino acid metabolism.
\nTo understand the role of intracellular complement in health and disease, we employ a combinatorial approach including application of pertinent mouse models (using unique floxed mouse strains with cell-specific deficiencies in C3 or C5 \u2013 generated on our lab), and assessment of novel discovered intracellular complement-mediated cell physiological pathways in patients with autoimmune disease, infections, or cancer via \u2018omic\u2019 techniques including CyTOF technology, ChIP-Seq, RNA-Seq, scRNA-seq, CITE-Seq and ATAC-Seq.<\/p>\n
Required Qualifications:<\/strong><\/p>\n NIH offers excellent salary and health care packages to its trainees and has consistently been ranked among the best places to work for postdoctoral fellows. The candidate will join a diverse and team-work oriented laboratory supported with an excellent intramural NIH fellowship in a stimulating and interactive research environment at NIH. CIRS is embedded in a broad national and international collaborative network, providing ample opportunities for extensive collaborations and an environment with a roadmap into independence. To apply:<\/strong><\/p>\n\n
\nwith less than two years of postdoctoral experience.<\/li>\n
\napproaches and collaborative research<\/li>\n
\nAppointees may be US citizens, resident aliens, or non-resident aliens with or eligible to obtain a valid employment authorized visa. Salary is commensurate with research experience and accomplishments.
\nApplications from women, minorities and persons with disabilities are strongly encouraged.<\/p>\n