Chronicle of a Neuronal Death Foretold: Preventing Aging by Keeping MGRN1 at the Nucleus.
Ortolano NA , Gama V , . Molecular cell. 2017 5 4; 66(3). 301-303
- PMID: 28475865 [PubMed].
In this issue of Molecular Cell, Benvegnù et al. (2017) report an unexpected phenomenon by which the E3 ligase mahogunin ring finger-1 (MGRN1) translocates to the nucleus in an age-dependent manner, revealing an intriguing mechanism that allows for an adaptive neuronal response to proteotoxic stress, often seen with aging.
Tags: Publications, Student Publications