Targeting MYC through WDR5
AUTHORS
Thomas
LR ,
Adams
CM ,
Fesik
SW ,
Eischen
CM ,
Tansey
WP ,
. Molecular & cellular oncology. 2020 1 10; 7(2). 1709388
- PMID: 32158922 [PubMed].
ABSTRACT
The oncoprotein transcription factor MYC is overexpressed in most cancers and is responsible for hundreds of thousands of cancer deaths worldwide every year. MYC is also a highly validated – but currently undruggable – anti-cancer target. We recently showed that breaking the interaction of MYC with its chromatin co-factor WD repeat-containing protein 5 (WDR5) promotes tumor regression in mouse xenografts, laying the foundation for a new strategy to inhibit MYC in the clinic.
Tags: Publications