Systems structural biology.
My main project involves understanding the decision process controlling the fate of a cell. Particularly, I am interested in how a cell commits to apoptosis, the main form of programmed cell death in human cells. When apopotisis-inducing drugs are given to a population of genetically identical cells, some die while others survive. If the drug is removed and the cells that resisted apoptosis are allowed to repopulate, one would think the new population would also be resistant if the drug was reintroduced. However, the same fraction of cells survive. This phenomena is observed across many cancer types and drugs. Why do some cells die and others survive? Towards answering this question, I build detailed models of the signaling process involved in cellular response to drugs.
Carlos F. Lopez
Fischer AW, Heinze S, Putnam DK, Li B, Pino JC, Xia Y, Lopez CF, Meiler J. CASP11 - An Evaluation of a Modular BCL::Fold-Based Protein Structure Prediction Pipeline. PloS one. 11(4). e0152517. PMID: 27046050 [PubMed].
University of Tennessee at Chattanooga, B.S. Physics
- Norris JL, Farrow MA, Gutierrez DB, Palmer LD, Muszynski N, Sherrod SD, Pino JC, Allen JL, Spraggins JM, Lubbock AL, Jordan A, Burns W, Poland JC, Romer C, Manier ML, Nei YW, Prentice BM, Rose KL, Hill S, Van de Plas R, Tsui T, Braman NM, Keller MR, Rutherford SA, Lobdell N, Lopez CF, Lacy DB, McLean JA, Wikswo JP, Skaar EP, Caprioli RM. Integrated, High-Throughput, Multiomics Platform Enables Data-Driven Construction of Cellular Responses and Reveals Global Drug Mechanisms of Action. Journal of proteome research. 2017 Mar 3;16(3). 1364-1375. PMID: 28088864 [PubMed].
- Chifman J, Arat S, Deng Z, Lemler E, Pino JC, Harris LA, Kochen MA, Lopez CF, Akman SA, Torti FM, Torti SV, Laubenbacher R. Activated Oncogenic Pathway Modifies Iron Network in Breast Epithelial Cells: A Dynamic Modeling Perspective. PLoS computational biology. 2017 Feb;13(2). e1005352. PMID: 28166223 [PubMed].
- Mansouri AL, Grese LN, Rowe EL, Pino JC, Chennubhotla SC, Ramanathan A, O'Neill HM, Berthelier V, Stanley CB. Folding propensity of intrinsically disordered proteins by osmotic stress. Molecular bioSystems. 2016 Oct 18. PMID: 27752679 [PubMed].
- Fischer AW, Heinze S, Putnam DK, Li B, Pino JC, Xia Y, Lopez CF, Meiler J. CASP11 - An Evaluation of a Modular BCL::Fold-Based Protein Structure Prediction Pipeline. PloS one. 11(4). e0152517. PMID: 27046050 [PubMed].