Yan Xia

Yan Xia

Chemical and Physical Biology PhD Candidate, Jens Meiler lab

5154e MRB III

Research Area

Characterizing the TSPO structure and ligand binding mechanism.
The translocator protein is an important outer mitochondrial membrane protein that facilitates cholesterol transport, oxidative stress sensing, and apoptosis. We use nuclear magnetic resonance (NMR) spectroscopy, electron paramagnetic resonance (EPR) spectroscopy, and computational modeling to characterize the structure and ligand binding-induced conformational changes of the protein.

Computational modeling to shed light on metabotropic glutamate receptor (mGluRs) signaling.
We employ a variety of computational ligand docking and protein-protein docking methods in Rosetta to formulate hypotheses on how inter-domain signal transduction and receptor activation/inactivation function in mGluRs based on published structures.

Faculty Mentor

Jens Meiler

Undergraduate Institution

Nanyang Technological University

Selected Publications