- Tang D, Li J, Buck JR, Tantawy MN, Xia Y, Harp JM, Nickels ML, Meiler J, Manning HC. Evaluation of TSPO PET Ligands [(18)F]VUIIS1009A and [(18)F]VUIIS1009B: Tracers for Cancer Imaging. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2016 Nov 16. PMID: 27853987 [PubMed].
Positron emission tomography (PET) ligands targeting translocator protein (TSPO) are potential imaging diagnostics of cancer. In this study, we report two novel, high-affinity TSPO PET ligands that are 5,7 regioisomers, [(18)F]VUIIS1009A ([(18)F]3A) and [(18)F]VUIIS1009B ([(18)F]3B), and their initial in vitro and in vivo evaluation in healthy mice and glioma-bearing rats.