• Claassen DO, Stark AJ, Spears CA, Petersen KJ, Van Wouwe NC, Kessler RM, Zald DH, Donahue MJ. Mesocorticolimbic hemodynamic response in Parkinson's disease patients with compulsive behaviors. Movement disorders : official journal of the Movement Disorder Society. 2017 Jun 19. PMID: 28627133 [PubMed].


PD patients treated with dopamine therapy can develop maladaptive impulsive and compulsive behaviors, manifesting as repetitive participation in reward-driven activities. This behavioral phenotype implicates aberrant mesocorticolimbic network function, a concept supported by past literature. However, no study has investigated the acute hemodynamic response to dopamine agonists in this subpopulation.