• Chaplin V, Caskey CF. Multi-focal HIFU reduces cavitation in mild-hyperthermia. Journal of therapeutic ultrasound. 5. 12 p. PMID: 28413682 [PubMed]. PMCID: PMC5390440.


Mild-hyperthermia therapy (40-45 °C) with high-intensity focused ultrasound (HIFU) is a technique being considered in a number of different treatments such as thermally activated drug delivery, immune-stimulation, and as a chemotherapy adjuvant. Mechanical damage and loss of cell viability associated with HIFU-induced acoustic cavitation may pose a risk during these treatments or may hinder their success. Here we present a method that achieves mild heating and reduces cavitation by using a multi-focused HIFU beam. We quantify cavitation level and temperature rise in multi-focal sonications and compare it to single-focus sonications at the transducer geometric focus.