• Fenix AM, Burnette DT. A small part of myosin IIB takes on a big role in cell polarity. The Journal of cell biology. 2015 Apr 13;209(1). 11-2. PMID: 25869662 [PubMed]. PMCID: PMC4395479.


A migrating cell must establish front-to-back polarity in order to move. In this issue, Juanes-Garcia et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201407059) report that a short serine-rich motif in nonmuscle myosin IIB is required to establish the cell's rear. This motif represents a new paradigm for what determines directional cell migration.