Publications (Gama Lab members underlined)

2017

  1. Natalya Ortolano, Vivian Gama. "Chronicle of a Neuronal Death Foretold: Preventing Aging by Keeping MGRN1 at the Nucleus". Molecular Cell, Volume 66, Issue 3, p301–303. http://www.cell.com/molecular-cell/fulltext/S1097-2765(17)30270-8
  2. William D’Angelo, Chandan Gurung, Dhiraj Acharya, Bohan Chen, Natalya​ Ortolano, Vivian Gama, and Yan-Lin Guo.“The Molecular Basis for the Lack of Inflammatory Responses in Mouse Embryonic Stem Cells” Journal of Immunology, January 27,2017, 1601068. DOI: https://doi.org/10.4049/jimmunol.1601068

Vivian's Postdoc & Ph.D. work:

2015

  1. Gama V. and Deshmukh M. 2015.  Life after MOMP.  Mol. Cell.  

2014

  1. Gama V., Swahari V., Schaffer J., Kole A., Huang Y., Evans A., Golitz B., Sciaky N., Johnson G. and Deshmukh M. 2014. PARC/Cul9 Mediates the Degradation of Mitochondrial-released Cytochrome c. Science Signaling. 7, ra67. (Perspective in Sci. Signal. 7, pe17 (2014)).

2013

  1. Crowther A.J#, Gama V#, Bevilacqua A., Chang S.X., Yuan H., Deshmukh M. and Gershon T.R. 2013. Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma.  J. Neuroscience. 33: 18098-18108.  #Equal contribution.
  2. Gama V. and Deshmukh M. 2013. Adenosine: Essential for life but licensed to kill.  Mol. Cell.  50(3):307-8.

2012

  1. Dumitru R#, Gama V#, Fagan BM, Swahari VJ., Bower JJ, Pevny LH and Deshmukh M. 2012. Human Embryonic Stem Cells have Constitutively Active Bax at the Golgi and are Primed to Undergo Rapid Apoptosis. Mol. Cell. 46: 573-583.  #Equal contribution. (Preview in Mol. Cell (2012) 46:554-556; Highlighted in Nat. Rev. Mol. Cell Bio. (2012) 13: 340).
  2. Gama V. and Deshmukh M. 2012. Human ES cells: Living on the Edge. Cell Cycle. 11(21): 3905-3906.
  3. Garcia I., Crowther A., Gama V., Miller R., Deshmukh M., Gershon T., 2012. Bax-deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation. Oncogene. 1-11.
  4. Londoño C., Osorio C., Gama V. and Alzate O. 2012. Mortalin, Apoptosis and Neurodegeneration. Review.  Biomolecules.  2: 143-164.

2011

  1. Leskov KS., Araki S., Lavik JP., Gomez J., Gama V., Trougakos I.P., Gonos E.S., Matsuyama S., and Boothman DA. 2011. CRM1-mediated Regulation of Nuclear Clusterin (nCLU), an Ionizing Radiation-stimulated, Bax-dependent Pro-death Factor. J. Biol. Chem. 286(46):40083-40090.
  2. Gomez J., Hajkova D., Gama V., Yeh IY., Miyagi M., and Matsuyama S.  2011. Cell Permeable Pentapeptides (CPP5s) as Protein Transduction Domains. Pharmaceuticals. 3(12):3594-3613.

2009

  1. Gomez J., Gomez JA, Sun W, Gama V., Hajkova D, Yoshida T, Wu Z, Miyagi M, Pink JJ, Jackson MW, Danielpour D, Matsuyama S. 2009. The C-terminus of interferon gamma receptor beta chain (IFNgammaR2) has antiapoptotic activity as a Bax inhibitor. Cancer Biol. Therapy. 8(18):1771-86. 
  2. Gama V., Gomez JA., Mayo LD. Danielpour D., Song K., Jackson M.W., Haas AL., and Matsuyama S.  2009.  Hdm2 is a Ubiquitin Ligase of Ku70-Akt Promotes Cell Survival by Inhibiting Hdm2-dependent Ku70 Destabilization. Cell Death Differ. 16(5):758-769.

2008

  1. Plesca D. Mazumder S., Gama V., Matsuyama S., Almasan A.  2008. A C-terminal fragment of Cyclin E, generated by caspase-mediated cleavage, is degraded in the absence of a recognizable phosphodegron.  J. Biol. Chem.   283(45): 30796-30803.
  2. Yurchenko V, Xue Z, Gama V.,Matsuyama S., Sadofsky M. 2008.Ku70 is stabilized by increased cellular SUMO. Biochem. Biophys. Res. Commun. 366(1):263-268.

2007

  1. Gomez J, Gama V., Yoshida T, Sun W, Hayes P, Leskov K, Boothman DA, and Matsuyama S. 2007. Bax Inhibiting Peptide and Cell Penetrating Penta-Peptides. Biochem. Soc. Trans. 35 (Pt 4):797-801.
  2. Gomez J., Gama V., and Matsuyama S.  2007. Cell Permeable Penta-Peptides Derived from Bax Inhibiting Peptide. Handbook of Cell-Penetrating Peptides: 469-481.  2nd Edition, CRC Press
  3. Li Y., Yokota T., Gama V., Yoshida T., Gomez J., Ishikawa,K., Cohen HY., Sinclair D.A., Mizusawa, H., and Matsuyama S. 2007. Bax-inhibiting peptide (BIP) protects cells from polyglutamine toxicity that induces Ku70 acetylation. Cell Death Differ. 14(12):2058-67.

2006 (and previous years)

  1. Gama V., Yoshida T., Gomez J., Basile D., Mayo L., Haas A., and Matusuyama S. 2006.  Involvement of the Ubiquitin Pathway in Decreasing Ku70 Levels in Response to Drug-induced Apoptosis.  Exp. Cell Res. 312(4):488-499.
  2. Yoshida T., Tomioka I., Nagahara T., Holyst T., Hayes P., Gama V., Okuno M., Chen Y , Abe Y., Kanouchi T., Sasada H., Wang D., Yokota T., and Matsuyama S. 2004. Bax inhibiting peptide derived from mouse and rat Ku70. Biochem. Biophys. Res. Commun. 321(4): 961-966.
  3. Martinez J., Gama V., Valderrama L., Leiby D., and N.G. Saravia. 2000. Clonal diversity in the expression and stability of the metastatic capability of Leishmania guyanensis in the golden hamster. J. Parasitol. 86(4):792-799.
  4. Lucumi A., Gama V., Robledo S., and N.G. Saravia. 1998. Sensitivity of Leishmania to Pentavalent Antimony is correlated with the formation of cleavable DNA-PROTEIN complexes. Antimicrob. Agents and Chemother. 42(8):1990-5.
  5. Osorio Y., Gama V., and B. Travi. 1998. Reinfection in American Cutaneous Leishmaniasis: Evaluation of Clinical outcomes in the hamster model. Mem. Inst. Oswaldo Cruz. 93(3): 353-356.
  6. Gama V., Valderrama L., and N.G. Saravia. 1997. Pathogenicity and Virulence models in Leishmania Viannia. Biomedica. 17(2):199-201.