Model for CR anchoring in cytokinesis. Proper PIP composition, dependent on Efr3, promotes CR anchoring. When PM lipid and CR protein composition is altered, CRs can slide. Cdc15 is an independent mechanism for CR anchoring as cdc15 mutants combined with efr3Δ results in exacerbated CR sliding defects. Disruption of CR positioning machinery in combination with efr3Δ leads to exacerbation of off-center septa. Image credit: 10.1083/jcb.201705070.