Dr. Alyssa Hasty earned her Ph.D. at Vanderbilt University in the laboratory of Dr. Sergio Fazio and then completed a postdoctoral fellowship at Tokyo University in the laboratory of Dr. Hitoshi Shimano. She was recruited back to Vanderbilt as a faculty member in the Department of Molecular Physiology and Biophysics (MPB), and is now a Full-Professor. Dr. Hasty is particularly interested in graduate education and as such, serves as the Director of Graduate Studies for the MPB Department. Dr. Hasty is a leader in the field of immunometabolism, primarily studying the role of macrophages in obesity and metabolic disease. She developed one of the first mouse models to study obesity-related hyperlipidemia and atherosclerosis. She is also interested in the nutritional aspects of metabolic disease including a focus on the impact of various dietary fatty acids on metabolism. Her current work focuses on adipose tissue macrophage apoptosis and iron handling. Dr. Hasty has received funding from the Veteran's Administration, American Heart Association, American Diabetes Association, and National Institutes of Health. She has published over 80 original papers and review/book chapters.
- Orr JS, Kennedy AJ, Hill AA, Anderson-Baucum EK, Hubler MJ, Hasty AH. CC-chemokine receptor 7 (CCR7) deficiency alters adipose tissue leukocyte populations in mice. Physiological reports. 2016 Sep;4(18). CC-Chemokine receptor 7 (CCR7) deficiency alters adipose tissue leukocyte populations in mice PMID: 27655794 [PubMed]. PMCID: PMC5037919.
- Ong HH, Webb CD, Gruen ML, Hasty AH, Gore JC, Welch EB. Fat-water MRI of a diet-induced obesity mouse model at 15.2T. Journal of medical imaging (Bellingham, Wash.). 2016 Apr;3(2). 026002 p. PMID: 27226976 [PubMed]. PMCID: PMC4877437.
- Hill AH, Anderson-Baucum EK, Kennedy AJ, Webb CD, Yull FE, Hasty AH. Activation of NF-κB drives the enhanced survival of adipose tissue macrophages in an obesogenic environment. Molecular Metabolism. ELSEVIER; 2015 Jul. Activation of NF-κB drives the enhanced survival of adipose tissue macrophages in an obesogenic environment File
- Riley KG, Pasek RC, Maulis MF, Dunn JC, Bolus WR, Kendall PL, Hasty AH, Gannon M. Macrophages are essential for CTGF-mediated adult β-cell proliferation after injury. Molecular Metabolism. ELSEVIER; 2015 May 19. Macrophages are essential for CTGF-mediated adult β-cell proliferation after injury. File
- Bolus WR, Gutierrez DA, Kennedy AJ, Anderson-Baucum EK, Hasty AH. CCR2 deficiency leads to increased eosinophils, alternative macrophage activation, and type 2 cytokine expression in adipose tissue. Journal of leukocyte biology. 2015 May 1. File PMID: 25934927 [PubMed].
- Hubler MJ, Peterson KR, Hasty AH. Iron homeostasis: a new job for macrophages in adipose tissue? Trends in endocrinology and metabolism: TEM. 2015 Jan 16. PMID: 25600948 [PubMed].
- Hill AA, Bolus WR, Hasty AH. A decade of progress in adipose tissue macrophage biology. Immunological reviews. 2014 Nov;262(1). 134-52. File PMID: 25319332 [PubMed]. PMCID: PMC4203421. NIHMSID: NIHMS622918.
- Anderson-Baucum EK, Major AS, Hasty AH. A possible secondary immune response in adipose tissue during weight cycling: The ups and downs of yo-yo dieting. Adipocyte. 2014 Apr 1;3(2). 141-5. PMID: 24719788 [PubMed]. PMCID: PMC3979879.
- Orr JS, Kennedy A, Anderson-Baucum EK, Webb CD, Fordahl SC, Erikson KM, Zhang Y, Etzerodt A, Moestrup SK, Hasty AH. Obesity alters adipose tissue macrophage iron content and tissue iron distribution. Diabetes. 2014 Feb;63(2). 421-32. PMID: 24130337 [PubMed]. PMCID: PMC3900546.
- Hasty AH, Gutierrez DA. What have we really learned about macrophage recruitment to adipose tissue? Endocrinology. 2014 Jan;155(1). 12-4. PMID: 24364586 [PubMed]. PMCID: PMC3868801.
- Hasty AH, Yvan-Charvet L. Liver X receptor α-dependent iron handling in M2 macrophages: The missing link between cholesterol and intraplaque hemorrhage? Circulation research. 2013 Nov 8;113(11). 1182-5. PMID: 24201110 [PubMed].
- Kennedy A, Webb CD, Hill AA, Gruen ML, Jackson LG, Hasty AH. Loss of CCR5 results in glucose intolerance in diet-induced obese mice. American journal of physiology. Endocrinology and metabolism. 2013 Oct 1;305(7). E897-906. PMID: 23941876 [PubMed]. PMCID: PMC3798705.
- Anderson EK, Gutierrez DA, Kennedy A, Hasty AH. Weight cycling increases T-cell accumulation in adipose tissue and impairs systemic glucose tolerance. Diabetes. 2013 Sep;62(9). 3180-8. PMID: 23733197 [PubMed]. PMCID: PMC3749340.