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I study the role of eosinophils in adipose tissue homeostasis, specifically during periods of weight gain or weight loss. In particular, I seek to understand how eosinophils impact key aspects of adipose tissue physiology such as macrophage inflammatory state, vascularization, extracellular matrix remodeling, and adipocyte insulin sensitivity.
- Bolus WR, Peterson KR, Hubler MJ, Kennedy AJ, Gruen ML, Hasty AH. Elevating adipose eosinophils in obese mice to physiologically normal levels does not rescue metabolic impairments. Molecular metabolism. 2017 Dec 16. Click here for direct link to publication website. File PMID: 29306658 [PubMed].
- Riley KG, Pasek RC, Maulis MF, Dunn JC, Bolus WR, Kendall PL, Hasty AH, Gannon M. Macrophages are essential for CTGF-mediated adult β-cell proliferation after injury. Molecular Metabolism. ELSEVIER; 2015 May 19. Click here for direct link to publication website. File
- Bolus WR, Gutierrez DA, Kennedy AJ, Anderson-Baucum EK, Hasty AH. CCR2 deficiency leads to increased eosinophils, alternative macrophage activation, and type 2 cytokine expression in adipose tissue. Journal of leukocyte biology. 2015 May 1. Click here for direct link to publication website. File PMID: 25934927 [PubMed].
- Hill AA, Bolus WR, Hasty AH. A decade of progress in adipose tissue macrophage biology. Immunological reviews. 2014 Nov;262(1). 134-52. File PMID: 25319332 [PubMed]. PMCID: PMC4203421. NIHMSID: NIHMS622918.