Pharmacoepidemiology, Geriatrics, Preventative Medicine
Wayne Ray, Ph.D., is a Professor of Health Policy at Vanderbilt University School of Medicine. His undergraduate work was in Mathematics at the University of Washington (1971) and he has a master’s degree in biostatistics (1974) and Computer Science (1981), both from Vanderbilt. He founded the Vanderbilt Master of Public Health program. He has been a Fellow of the International Society for Pharmacoepidemiology and is the winner of Vanderbilt awards for innovative teaching (2004) and translational research (2015).
Dr. Ray has had a long-standing research interest in population-based studies of therapeutic interventions and has published 200 studies that use observational methods to assess safety and efficacy or seek to define and improve suboptimal use of therapeutic interventions. Dr. Ray pioneered the methodology for using large automated databases, particularly Medicaid, for these types of studies. His work includes fundamental studies of psychotropic drugs and injuries, nonsteroidal anti-inflammatory drugs (NSAIDs) and upper gastrointestinal disease, NSAIDs/coxibs and the risk of coronary heart disease, and a variety of medications and the risk of sudden cardiac death.
- Ray WA, Chung CP, Murray KT, Smalley WE, Daugherty JR, Dupont WD, Stein CM. Association of Proton Pump Inhibitors With Reduced Risk of Warfarin-Related Serious Upper Gastrointestinal Bleeding. Gastroenterology. 2016 Dec;151(6). 1105-1112.e10. PMID: 27639805 [PubMed]. PMCID: PMC5124401. NIHMSID: NIHMS816849.
- Ray WA, Chung CP, Murray KT, Hall K, Stein CM. High-Dose Citalopram and Escitalopram and the Risk of Out-of-Hospital Death. The Journal of clinical psychiatry. 2016 Oct 11. PMID: 27736049 [PubMed].
- Ray WA, Chung CP, Murray KT, Hall K, Stein CM. Prescription of Long-Acting Opioids and Mortality in Patients With Chronic Noncancer Pain. JAMA. 2016 Jun 14;315(22). 2415-23. PMID: 27299617 [PubMed].
- Ray WA, Chung CP, Murray KT, Cooper WO, Hall K, Stein CM. Out-of-Hospital Mortality Among Patients Receiving Methadone for Noncancer Pain. JAMA internal medicine. 2015 Mar 1;175(3). 420-7. PMID: 25599329 [PubMed]. PMCID: PMC4346542. NIHMSID: NIHMS641066.
- Ray WA, Liu Q, Shepherd BE. Performance of time-dependent propensity scores: a pharmacoepidemiology case study. Pharmacoepidemiology and drug safety. 2015 Jan;24(1). 98-106. PMID: 25408360 [PubMed]. PMCID: PMC4331352. NIHMSID: NIHMS641068.
- Chung CP, Callahan ST, Cooper WO, Murray KT, Hall K, Dudley JA, Michael Stein C, Ray WA. Development of an algorithm to identify serious opioid toxicity in children. BMC research notes. 8. 293 p. PMID: 26141980 [PubMed]. PMCID: PMC4491206.
- Kawai VK, Cunningham A, Vear SI, Van Driest SL, Oginni A, Xu H, Jiang M, Li C, Denny JC, Shaffer C, Bowton E, Gage BF, Ray WA, Roden DM, Stein CM. Genotype and risk of major bleeding during warfarin treatment. Pharmacogenomics. 2014 Dec;15(16). 1973-83. PMID: 25521356 [PubMed]. PMCID: PMC4304738. NIHMSID: NIHMS652646.
- Ray WA. Azithromycin associated with a reduction in 90-day mortality among older pneumonia patients, although a true clinical benefit is uncertain. Evidence-based medicine. 2014 Dec;19(6). 226-7. PMID: 25121563 [PubMed].
- Cooper WO, Cheetham TC, Li DK, Stein CM, Callahan ST, Morgan TM, Shintani AK, Chen N, Griffin MR, Ray WA. Brief report: Risk of adverse fetal outcomes associated with immunosuppressive medications for chronic immune-mediated diseases in pregnancy. Arthritis & rheumatology (Hoboken, N.J.). 2014 Feb;66(2). 444-50. PMID: 24504818 [PubMed]. PMCID: PMC4077326. NIHMSID: NIHMS597798.
- Bobo WV, Cooper WO, Stein CM, Olfson M, Graham D, Daugherty J, Fuchs DC, Ray WA. Antipsychotics and the risk of type 2 diabetes mellitus in children and youth. JAMA psychiatry. 2013 Oct;70(10). 1067-75. PMID: 23965896 [PubMed].
- Callahan ST, Fuchs DC, Shelton RC, Balmer LS, Dudley JA, Gideon PS, Deranieri MM, Stratton SM, Williams CL, Ray WA, Cooper WO. Identifying suicidal behavior among adolescents using administrative claims data. Pharmacoepidemiology and drug safety. 2013 Jul;22(7). 769-75. PMID: 23412882 [PubMed]. PMCID: PMC3785233. NIHMSID: NIHMS447300.
- Ray WA, Murray KT, Kawai V, Graham DJ, Cooper WO, Hall K, Stein CM. Propoxyphene and the risk of out-of-hospital death. Pharmacoepidemiology and drug safety. 2013 Apr;22(4). 403-12. PMID: 23408551 [PubMed]. PMCID: PMC3694329. NIHMSID: NIHMS447305.
- Eckrich MJ, Wang WC, Yang E, Arbogast PG, Morrow A, Dudley JA, Ray WA, Cooper WO. Adherence to transcranial Doppler screening guidelines among children with sickle cell disease. Pediatric blood & cancer. 2013 Feb;60(2). 270-4. PMID: 22744996 [PubMed].
- Ray WA, Murray KT, Hall K, Arbogast PG, Stein CM. Azithromycin and the risk of cardiovascular death. The New England journal of medicine. 2012 May 17;366(20). 1881-90. PMID: 22591294 [PubMed]. PMCID: PMC3374857. NIHMSID: NIHMS381524.
- Kawai VK, Murray KT, Stein CM, Cooper WO, Graham DJ, Hall K, Ray WA. Validation of a computer case definition for sudden cardiac death in opioid users. BMC research notes. 5. 473 p. PMID: 22938531 [PubMed]. PMCID: PMC3512474.
- Bobo WV, Cooper WO, Stein CM, Olfson M, Mounsey J, Daugherty J, Ray WA. Positive predictive value of a case definition for diabetes mellitus using automated administrative health data in children and youth exposed to antipsychotic drugs or control medications: a Tennessee Medicaid study. BMC medical research methodology. 12. 128 p. PMID: 22920280 [PubMed]. PMCID: PMC3500229.
- Bobo WV, Cooper WO, Epstein RA, Arbogast PG, Mounsey J, Ray WA. Positive predictive value of automated database records for diabetic ketoacidosis (DKA) in children and youth exposed to antipsychotic drugs or control medications: a Tennessee Medicaid Study. BMC medical research methodology. 11. 157 p. PMID: 22112194 [PubMed]. PMCID: PMC3235973.