Amy Tran
University of Cincinnati
Kevin Schey and Jens Meiler Labs
My research focuses on studying antibody-antigen interactions with hydrogen deuterium exchange mass spectrometry (HDX-MS). To complement the peptide level resolution of HDX-MS, I will apply computational methods to construct high resolution models, ideally identifying residue-residue contacts between antibodies and antigens using the Rosetta software suite. My aims are benchmarking a new RosettaHDX method and applying RosettaHDX to study antibodies that bind to the trimeric interface of hemagglutinin with the potential to inform influenza vaccine design.