California State Polytechnic University
Henrique Serezani Lab
I am a graduate student in the Microbe-Host Interactions graduate program in the Pathology, Microbiology, and Immunology Department. My research focuses on the immunometabolic profile of macrophages and how this profile can influence a dysregulated immune response during sepsis. My focus is on the tumor suppressor, phosphatase and tensin homolog (PTEN), which can modulate mitochondrial and cellular metabolism via the PI3K/Akt/mTORC1 pathways. We aim to unveil a new regulatory axis involving different processes (phosphatase activation, inflammasome activation, along with fatty acid generation and oxidation) that regulate homeostatic events and, when alternated, leads to an exaggerated inflammatory response that culminates in organ damage and mortality.