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Mary Chalkley

Barnard College

Kevin Ess and Rebecca Ihrie labs

Tuberous Sclerosis is a genetic disorder caused by a mutation in the gene TSC2 that leads to an overactive mTORC1. mTORC1 controls different cell processes like metabolism, growth, and translation among others. Using patient derived induced pluripotent stem cells, I study how a mutation in TSC2 leads to aberrant neurodevelopment.