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Tata Kavlashvili

University of Iowa

James Dewar lab

My research in the Dewar lab focuses on the final stage of DNA replication, which is called 'termination'. Termination is the most poorly-understood stage of DNA replication and is not believed to be integrated into the cell cycle, in contrast to earlier stages of replication. The Dewar lab has performed biochemical screens for termination proteins and identified several cell cycle regulators that bind during termination. I am currently investigating the roles of these proteins during termination and will determine how they affect the cell cycle. We hypothesize that the completion of DNA synthesis is subject to surveillance and regulates ensuing cell cycle events.