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Staphylococcus aureus exhibits heterogeneous siderophore production within the vertebrate host


Perry WJ , Spraggins JM , Sheldon JR , Grunenwald CM , Heinrichs DE , Cassat JE , Skaar EP , Caprioli RM , . Proceedings of the National Academy of Sciences of the United States of America. 2019 10 14; 116(44). 21980-21982


Siderophores, iron-scavenging small molecules, are fundamental to bacterial nutrient metal acquisition and enable pathogens to overcome challenges imposed by nutritional immunity. Multimodal imaging mass spectrometry allows visualization of host-pathogen iron competition, by mapping siderophores within infected tissue. We have observed heterogeneous distributions of siderophores across infectious foci, challenging the paradigm that the vertebrate host is a uniformly iron-depleted environment to invading microbes.