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Imaging the clear cell renal cell carcinoma proteome.


Morgan| Seeley| Fadare| Caprioli| Clark TM| EH| O| RM| PE , . The Journal of urology. 2013 3 ; 189(3). 1097-103


A key barrier to identifying tissue biomarkers of clear cell renal cell carcinoma is the heterogeneity of protein expression in tissue. However, by providing spectra for every 0.05 mm(2) area of tissue, imaging mass spectrometry reveals the spatial distribution of peptides. We determined whether this approach could be used to identify and map protein signatures of clear cell renal cell carcinoma.


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