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Protein identification in imaging mass spectrometry through spatially targeted liquid micro-extractions.


AUTHORS

Ryan| Nei| Prentice| Rose| Caprioli| Spraggins DJ| D| BM| KL| RM| JM , . Rapid communications in mass spectrometry : RCM. 2018 3 15; 32(5). 442-450

ABSTRACT

Liquid extraction surface analysis (LESA) can be used to generate spatially directed protein identifications in an imaging mass spectrometry (IMS) workflow. This approach involves the use of robotic micro-extractions coupled to online liquid chromatography (LC). We have characterized the extraction efficiency of this method as well as its ability to identify proteins from a matrix assisted laser/desorption ionization (MALDI) IMS experiment.



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