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Protein identification in imaging mass spectrometry through spatially targeted liquid micro-extractions.


Ryan| Nei| Prentice| Rose| Caprioli| Spraggins DJ| D| BM| KL| RM| JM , . Rapid communications in mass spectrometry : RCM. 2018 3 15; 32(5). 442-450


Liquid extraction surface analysis (LESA) can be used to generate spatially directed protein identifications in an imaging mass spectrometry (IMS) workflow. This approach involves the use of robotic micro-extractions coupled to online liquid chromatography (LC). We have characterized the extraction efficiency of this method as well as its ability to identify proteins from a matrix assisted laser/desorption ionization (MALDI) IMS experiment.

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