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Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer.


AUTHORS

Nagathihalli| Castellanos| Shi| Beesetty| Reyzer| Caprioli| Chen| Walsh| Skala| Moses| Merchant NS| JA| C| Y| ML| R| X| AJ| MC| HL| NB , . Gastroenterology. 2015 12 ; 149(7). 1932-1943.e9

ABSTRACT

A hallmark of pancreatic ductal adenocarcinoma (PDAC) is the presence of a dense desmoplastic reaction (stroma) that impedes drug delivery to the tumor. Attempts to deplete the tumor stroma have resulted in formation of more aggressive tumors. We have identified signal transducer and activator of transcription (STAT) 3 as a biomarker of resistance to cytotoxic and molecularly targeted therapy in PDAC. The purpose of this study is to investigate the effects of targeting STAT3 on the PDAC stroma and on therapeutic resistance.



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