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The National Research Resource for Imaging Mass Spectrometry operates within the Mass Spectrometry Research Center at Vanderbilt University, directed by Professor Richard Caprioli. This facility is a comprehensive facility for mass spectrometry research. Among the many contributions made to the field of mass spectrometry, Vanderbilt University has been the leading developer of imaging mass spectrometry for over a decade for both biological and clinical applications. The Mass Spectrometry Research Center encompasses over 40 full-time scientists and has more than 40 mass spectrometers. The Center consists of four groups: R&D laboratories, proteomics core laboratory, small molecule core laboratory, and the biocomputational group.

Vanderbilt University School of Medicine's biomedical research program has earned its place among the nation's top 10 academic medical centers for National Institutes of Health research funding. Vanderbilt University Medical Center is home to Vanderbilt University Hospital, The Monroe Carell Jr. Children's Hospital, the Psychiatric Hospital, and the Stallworth Rehabilitation Hospital. These hospitals received more than 48,000 inpatient admissions during fiscal year 2009. Vanderbilt's adult and pediatric outpatient clinics treated more than 1.2 million patients during this same period.

P41 Software and Resources

IMS Protocols

Instruments for IMS

Links to IMS Groups and Other Information


Instruments for IMS

Mass Spectrometers

  • Applied Biosystems MALDI-TOF (with customized source)
  • Applied Biosystems Voyager Elite MALDI-TOF
  • Applied Biosystems Voyager-DE STR MALDI-TOF
  • Bruker Daltonics UltrafleXtreme MALDI-TOF/TOF
  • Bruker Daltonics Autoflex Speed MALDI-TOF (Linear)
  • Bruker Daltonics Autoflex Speed MALDI-TOF (Linear/Reflectron)
  • Burker Daltonics Autoflex Speed MALDI-TOF/TOF (Reflectron/Tandem MS)
  • Bruker Daltonics Apex 9.4-Qe FTICR MS (MALDI & ESI)
  • Thermo Scientific MALDI LTQ XL ion trap MS systems
  • SimulTOF Systems MALDI-TOF (Linear)
  • SimulTOF Systems MALDI-TOF (Reflectron)
  • Waters Synapt HDMS Q-TOF with ion mobility capabilities (MALDI & ESI)


  • Bruker Image Prep Sprayer
  • Labcyte Automated Reagent Multispotter
  • Labcyte Portrait 630 Spotter (2)
  • HTX Technologies TM-Sprayer

Sectioning Equipment

  • Leica CM3600 Cryomacrotome
  • Leica CM3050S Cryostat
  • Leica CM1900 Cryostat
  • Thermo Scientific Microm HM325 microtome
  • Zeiss PALM laser capture microdissection unit


  • Zeiss Mirax Scan Microscope Slide Scanner
  • Olympus BX50 Microscope with Automatic Stage

Links to IMS Groups and Other Information

If you are engaged in Imaging Mass Spectrometry and would like your organization to be listed below, please contact us to provide consent.

Academic Groups (Institution | Laboratory Director)
AMOLF | Ron Heeren
Iowa State University | Young Jin Lee
Justus-Liebig University | Bernhard Spengler
Leech Neurobiology | Michel Salzet
Oak Ridge National Laboratory | Gary van Berkel
Pennsylvania State University | Nick Winograd
Purdue University | Graham Cooks
Sheffield Hallam University | Malcolm Clench
University of Birmingham | Josephine Bunch
University of California-San Diego | Pieter Dorrestein
University of Florida | Richard Yost
University of Illinois | Jonathan Sweedler
University of Montreal | Pierre Chaurand
University of Wisconsin | Lingjun Li
Upsala University | Per Andrén

Applied Biosystems
Bruker Daltonics
HTX Technologies, LLC
Labcyte, Inc.
Shimadzu Corporation
Thermo Scientific
SimulTOF Systems
Waters Corporation

Interest Groups
ASMS Interest Group
LinkedIn Mass Spectrometry Imaging Group
MALDI-IMS Interest Group

National Center for Research Resources (NCRR)
National Institutes of Health (NIH)

American Society for Mass Spectrometry (ASMS)
Human Proteome Organization (HuPO)
Imaging Mass Spectrometry Society