Inflammatory Macrophage Survival in Obese Adipose Tissue
Obesity has become a major worldwide health issue over the past few years that can lead to insulin resistance (IR) and type 2 diabetes. Macrophage inflammation in adipose tissue (AT) is thought to contribute to the development of IR in obese individuals. My research investigates the role of NF-κB in inflammatory adipose tissue macrophage (ATM) survival in obese adipose tissue. ATM inflammation is thought to contribute to the chronic inflammation in obese tissue that ultimately contributes to the development of insulin resistance and type 2 diabetes. Understanding the mechanisms by which NF-κB can help prolong ATM survival could help develop new therapies against these diseases.