My research focuses on the lipid signaling molecules and how these are altered by obesity. Specifically, how obesity causes a reduction in circulation of N-acylethanolamines (NAE). NAEs have been shown to have anorexic effect and reduce feedings and alter weight gain. We investigate the cellular and molecular mechanisms responsible for production of NAEs which include precursor synthesis and enzymatic production, through a combination of cellular and animal models utilizing a range of molecular and instrumental techniques. In our laboratory we also develop recombinant bacteria to alter the gut microbiome as a potential therapeutic treatment for obesity.
PI: Sean Davies, Ph.D.