Cell Signaling Pathways Related to Neurodegeneration and Protection
The goal of research in the McLaughlin lab is to understand the endogenous pathways associated with neurodegeneration and protection to develop novel therapeutics for stroke, cerebral palsy and other degenerative conditions. Studies in the lab include understanding how classical biochemical changes in ion homeostasis (specifically zinc, calcium and potassium homeostasis) induce the molecular pathways associated with apoptotic cell death. In this work we established a novel link between ROS and zinc induced activation of MAPKs and opening of potassium channels that are associated with apoptotic cell death. In addition, these studies investigate signaling pathways which provide protective mechanisms against other forms of cell death.