The Role of Sulfilimine Crosslinks in Tissue Genesis and Tumorigenesis and Progression
Collagen IV extracellular scaffolds are a principal component of the basement membrane (BM), a specialized form of extracellular matrix (ECM) that effects tissue tension, cell polarity, and cell-microenvironment relationships. During tissue generation and tumorigenesis, collagen IV scaffolds are assembled to support cellular proliferation, survival, and migration. Our lab has recently discovered a unique sulfilimine crosslink of collagen IV that reinforces the scaffold network. My study focuses on determining the role of the collagen IV sulfilimine crosslinks in epithelial arrangement. Additionally, I am investigating the role of sulfimine crosslinks in tumor supportive BM assembly and remodeling, which is required for tumorigenesis and progression.