B-cell Development and T-cell Acute Lymphobastic Leukemia
The maintenance of the hematopoietic system depends on the ability of hematopoietic stem cells (HSCs) to self-renew and differentiate into all blood cell lineages. When hematopoiesis is blocked in differentiation or has deregulated self-renewal, leukemia or lymphoma can result. The hematopoetically expressed homeobox (Hhex) is important for normal B-cell development and is also activated along with Lmo2 in T-cell acute lymphoblastic leukemia (T-ALL). However, the mechanism by which Hhex operates in normal and malignant hematopoiesis is not well understood. My research seeks to understand the roles of Hhex in B-cell development and T-ALL induction.