Christopher Arnette, Ph.D.

Christopher Arnette, Ph.D.

Cell & Developmental Biology, 2014

Advisor: Irina Kaverina, Ph.D.

Current Position: Postdoctoral Fellow, Northwestern University

Laboratory of Kathleen Green, Ph.D.

Dissertation Description

Mechanism and Regulation of Proto-oncogene Src Trafficking

My research focuses on determining the underlying mechanism by which the proto-oncogene Src is trafficked by the underlying microtubule and actin cytoskeleton. My work focuses on identifying the key molecular players that regulate and coordinate this concerted effort for the efficient delivery of Src, as well as how regulation of Src trafficking by the cytoskeleton influences the formation of degradative actin-rich structures, podosomes.

Additionally, I am also examining the role and function of the tumor suppressor RASSF1A. My work focuses on determining the mechanism by which RASSF1A exerts its tumor suppressor function through interaction with the microtubule network.