David Elion

David Elion

Cancer Biology

PI: Rebecca Cook, Ph.D.

My project evaluates the effect of local RIG-I activation ± TβR2 silencing on cytokines and leukocytes in the breast tumor microenvironment of both primary and metastatic breast tumors, using an immune competent murine model of metastatic breast cancer. I study how this effect impacts leukocyte populations, tumor growth, recurrence, and metastasis, and how immune suppression in the tumor microenvironment dramatically abrogates immune effector mechanisms.