The Role of Myeloid-Derived Suppressor Cells (MDSCs) in the Tumor Microenvironment
The Sterling lab studies the mechanisms that enable certain cancer types to metastasize to bone. These include breast, lung, oral, renal, and prostate cancer. One of my goals for my graduate studies is to understand the role of myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment and their contribution to bone metastasis in breast cancer. The hypothesis is that these cells initiate the metastatic niche and dictate where it establishes. By understanding how these cells affect the different cell signaling pathways within the tumor microenvironment, such as the TGF-β pathway, it will give a better idea of how early bone metastatic disease occurs. The more that is known about the tumor microenvironment the more opportunity there is to create targeted novel therapies.