Systems Biology Approach to Melanoma Treatment
The goal of my project is to improve current methods of treatment for melanoma by using a systems biology approach. I measure abnormal cell signaling events that improve incidences of proliferation and apoptosis evasion using phosphoflow cytometry. Cytoplasmic signaling is a mechanism that cells use to respond to their environment and regulate their biological activity. Cancer cells are unusual because they have discovered a way to make minor modifications of their signaling processing circuitry to stay alive. I focus on measuring signaling in melanoma, because it should provide a comprehensive view of cellular processes necessary for therapeutic resistance.