Gabriela L. Santos Guasch

Gabriela L. Santos Guasch

Biochemistry

PI: Jennifer Pietenpol, Ph.D.

The Role of p73 during Organ Development

The p53 family of proteins; p53, p63 and p73; are sequence-specific transcription factors that genes involved in cell cycle arrest, DNA repair, apoptosis, development and cell differentiation. p73, unlike p53, is rarely mutated in human cancers, which makes p73 a good therapeutic target. Using our genetically engineered p73 knockout mice, we will determine the role of p73 during normal development and determine signaling mechanisms by which p73 regulates organ function.